Pharmacological characterization of intraplantar Complete Freund’s Adjuvant-induced burrowing deficits

Gould, Stacey Anne; Doods, Henri; Lamla, Thorsten; Pekcec, Anton

doi:10.1016/j.bbr.2015.12.019

Cited by 29 publications

(35 citation statements)

References 41 publications

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“… 17 , 53 First, it should be demonstrated to what extent clinically efficacious drugs reverse suppression of burrowing. In the CFA model, ibuprofen has been shown to reverse suppressed burrowing, whereas gabapentin, which has a large body of evidence supporting efficacy in neuropathic, but not inflammatory, pain, is appropriately inefficacious, 2 , 20 , 62 suggesting good pharmacologic sensitivity of suppressed burrowing. Second, compounds such as neurokinin 1 antagonists and cannabinoid 2 receptor agonists that have been shown to be efficacious in animal pain models measuring evoked endpoints but have failed in clinical trials 48 , 65 , 75 should be tested to assess the degree of pain specificity of burrowing.…”

Section: Discussionmentioning

confidence: 99%

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Cross-centre replication of suppressed burrowing behaviour as an ethologically relevant pain outcome measure in the rat: a prospective multicentre study

Wodarski

Delaney

Ultenius

et al. 2016

Pain

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Section: Discussionmentioning

confidence: 99%

“… 45 Although burrowing is a relatively novel pain outcome measure, a few studies have reported decreased burrowing in rat models of inflammatory and neuropathic pain; importantly, burrowing deficits were reversed by known analgesics, suggesting a degree of predictive validity for this outcome measure. 2 , 9 , 20 , 35 , 61 , 62 …”

Section: Introductionmentioning

confidence: 99%

Cross-centre replication of suppressed burrowing behaviour as an ethologically relevant pain outcome measure in the rat: a prospective multicentre study

Wodarski

Delaney

Ultenius

et al. 2016

Pain

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“…As burrowing activity decreases in many conditions that are likely accompanied by negative affective states, the behavior has been subsequently used in mice and rats to assess the impact and refinement of housing and experimental conditions (see Figure 1). While burrowing activity in rats is mainly used to assess different pain types or analgesic efficacy (e.g., [67][68][69]), the use of this test in mice is more heterogeneous. Burrowing behavior is known to be reduced due to post-surgical pain (e.g., [70]), experimental procedures like anesthesia [71], or experimental housing conditions like grid housing [72].…”

Section: Burrowingmentioning

confidence: 99%

Assessing Affective State in Laboratory Rodents to Promote Animal Welfare—What Is the Progress in Applied Refinement Research?

Jirkof

Rudeck

Lewejohann

2019

Animals

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An animal’s capacity to suffer is a prerequisite for any animal welfare concern, and the minimization of suffering is a key aim of refinement research. In contrast to the traditional focus on avoiding or reducing negative welfare states, modern animal welfare concepts highlight the importance of promoting positive welfare states in laboratory animals. Reliable assessments of affective states, as well as the knowledge of how to elicit positive affective states, are central to this concept. Important achievements have been made to assess pain and other negative affective states in animals in the last decades, but it is only recently that the neurobiology of positive emotions in humans and animals has been gaining more interest. Thereby, the need for promotion of positive affective states for laboratory animals is gaining more acceptance, and methods allowing the assessment of affective states in animals have been increasingly introduced. In this overview article, we present common and emerging methods to assess affective states in laboratory rodents. We focus on the implementation of these methods into applied refinement research to identify achieved progress as well as the future potential of these tools to improve animal welfare in animal-based research.

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“…For example, the inclination of mice to build nests (from pieces of nesting material arranged in a standardized way in test cages) and the time taken to do so are decreased under conditions of inflammatory or visceral pain (Negus et al, ). Rats and mice will also burrow less (remove quantifiable amounts of material from an artificial burrow) when experiencing inflammatory or postsurgical pain (Jirkof et al, ; Andrews et al, ; Gould et al, ). Although these tests can assign numerical values to ongoing pain magnitude and effects of analgesics, in the case of SCI (in which their use has been practically nonexistent), they cannot provide information on pain locus (e.g., at‐ or below‐level pain).…”

Section: Measuring Neuropathic Pain Following Sci: What Is Required Imentioning

confidence: 99%

Neuropathic pain following traumatic spinal cord injury: Models, measurement, and mechanisms

Kramer

Minhas

Jutzeler

et al. 2016

J of Neuroscience Research

103

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Neuropathic pain following spinal cord injury (SCI) is notoriously difficult to treat and is a high priority for many in the SCI population. Resolving this issue requires animal models fidelic to the clinical situation in terms of injury mechanism and pain phenotype. This Review discusses the means by which neuropathic pain has been induced and measured in experimental SCI and compares these with human outcomes, showing that there is a substantial disconnection between experimental investigations and clinical findings in a number of features. Clinical injury level is predominantly cervical, whereas injury in the laboratory is modeled mainly at the thoracic cord. Neuropathic pain is primarily spontaneous or tonic in people with SCI (with a relatively smaller incidence of allodynia), but measures of evoked responses (to thermal and mechanical stimuli) are almost exclusively used in animals. There is even the question of whether pain per se has been under investigation in most experimental SCI studies rather than simply enhanced reflex activity with no affective component. This Review also summarizes some of the problems related to clinical assessment of neuropathic pain and how advanced imaging techniques may circumvent a lack of patient/clinician objectivity and discusses possible etiologies of neuropathic pain following SCI based on evidence from both clinical studies and animal models, with examples of cellular and molecular changes drawn from the entire neuraxis from primary afferent terminals to cortical sensory and affective centers. © 2016 Wiley Periodicals, Inc.

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Pharmacological characterization of intraplantar Complete Freund’s Adjuvant-induced burrowing deficits

Cited by 29 publications

References 41 publications

Cross-centre replication of suppressed burrowing behaviour as an ethologically relevant pain outcome measure in the rat: a prospective multicentre study

Cross-centre replication of suppressed burrowing behaviour as an ethologically relevant pain outcome measure in the rat: a prospective multicentre study

Assessing Affective State in Laboratory Rodents to Promote Animal Welfare—What Is the Progress in Applied Refinement Research?

Neuropathic pain following traumatic spinal cord injury: Models, measurement, and mechanisms

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