Pharmacological characterization of different fractions of Calotropis procera (Asclepiadaceae) in streptozotocin induced experimental model of diabetic neuropathy

Yadav, Sandeep Kumar; Nagori, Badri Prakash; Desai, Prashant Kumar

doi:10.1016/j.jep.2014.01.020

Cited by 29 publications

(14 citation statements)

References 32 publications

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“…1 . Hence this implies that extracts of Moringa stenopetala were also responsible for the proliferation of -cells as there are already reports showing extracts of other medicinal plants which have a -cell regenerative potential [ 21 ]. This medicinal plant material has also shown neovascularization activity in the pancreatic islets of Langerhans and improved stromal fibrosis of pancreatic cells in histopathological investigations.…”

Section: Discussionmentioning

confidence: 79%

Antidiabetic activities of aqueous ethanol and n-butanol fraction of Moringa stenopetala leaves in streptozotocin-induced diabetic rats

Toma

Makonnen

Mekonnen

et al. 2015

BMC Complement Altern Med

102

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BackgroundMoringa stenopetala has been used in traditional health systems to treat diabetes mellitus. The aim of this study was to investigate the antidiabetic activity of aqueous ethanol and n-butanol fraction of Moringa stenopetala leaves in streptozotocin (STZ) induced diabetic rats.MethodsThe aqueous ethanol extract and n-butanol fraction of Moringa stenopetala leaves hydroalcoholic (500 mg/kg body weight) and metformin (150 mg/kg body weight) were administered to diabetic rats. Blood glucose, lipid profiles, liver and kidney function were examined after 14 days of experiment. Histopathological profile of the pancreas was also observed in diabetic rats at the end of study. An oral sucrose challenge test was also carried out to assess the post prandial effect of the extract.ResultsOral administration of the aqueous ethanol and n-butanol extracts of Moringa stenopetala leaves (500 mg/kg body weight) and metformin (150 mg/kg) significantly reduced blood glucose level (P < 0.05), improved serum lipid profiles, liver enzymes and kidney functions in diabetic rats after 14 days. The extracts also improved damage of islet of Langerhan’s in diabetic rats. The plant material reduced the post-prandial glucose level (P < 0.001) at the dose of 750 mg/kg.ConclusionThese findings revealed that both the aqueous ethanol and n-butanol extracts of Moringa stenopetala leaves possess antihyperglycemic and antihyperlipidemic properties, and alleviate STZ-induced pancreatic damage in diabetic rats. The beneficial effects of plant material in inhibition of diabetes-induced complications are being investigated.

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Section: Discussionmentioning

confidence: 79%

Antidiabetic activities of aqueous ethanol and n-butanol fraction of Moringa stenopetala leaves in streptozotocin-induced diabetic rats

Toma

Makonnen

Mekonnen

et al. 2015

BMC Complement Altern Med

102

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“…The current results will be useful for assessing the benefit of A. radiata extracts in the treatment of diabetic neuropathy, a major complication associated with mitochondrial dysfunction, oxidative stress and inflammatory mediated damage in neurons and glial cells (Sandireddy et al, 2014;Singh et al, 2015). To this purpose, more specific protocols allowing the monitoring of peripheral nerve conduction velocity and injury are available (Yadav et al, 2014;Yang et al, 2015). More generally, it is believed that A. radiata-derived material is particularly suitable for developing a neutraceutical for the management of type 2 diabetes and obesity or for add-on therapy with metformin.…”

Section: Resultsmentioning

confidence: 99%

Antidiabetic, antioxidant and anti inflammatory properties of water and n-butanol soluble extracts from Saharian Anvillea radiata in high-fat-diet fed mice

Kandouli

Cassien

Mercier

et al. 2017

Journal of Ethnopharmacology

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“…Since pancreas contains stable (quiescent) β -cells which have the regenerative capacity, the surviving cells proliferate by replication to supplicate the lost cells [39]. New pancreatic β -cells can be formed by neogenesis or by replication of the preexisting differentiated cells [40]; hence it is assumed from the study that the extracts of Artemisia amygdalina are also responsible for the proliferation of β -cells, as there are already reports showing extracts of other medicinal plants which have a β -cell regenerative potential [41, 42]. …”

Section: Discussionmentioning

confidence: 99%

Antidiabetic Activity ofArtemisia amygdalinaDecne in Streptozotocin Induced Diabetic Rats

Ghazanfar

Ganai

Akbar

et al. 2014

BioMed Research International

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Artemisia species have been extensively used for the management of diabetes in folklore medicine. The current study was designed to investigate the antidiabetic and antihyperlipidemic effects of Artemisia amygdalina. Petroleum ether, ethyl acetate, methanol, and hydroethanolic extracts of Artemisia amygdalina were tested for their antidiabetic potentials in diabetic rats. The effect of extracts was observed by checking the biochemical, physiological, and histopathological parameters in diabetic rats. The hydroethanolic and methanolic extracts each at doses of 250 and 500 mg/kg b. w significantly reduced glucose levels in diabetic rats. The other biochemical parameters like cholesterol, triglycerides, low density lipoproteins (LDL), serum creatinine, serum glutamate pyruvate transaminase (SGPT), serum glutamate oxaloacetate transaminase (SGOT), and alkaline phosphatise (ALP), were found to be reduced by the hydroethanolic and methanolic extracts. The extracts also showed reduction in the feed and water consumption of diabetic rats when compared with the diabetic control. The histopathological results of treated groups showed the regenerative/protective effect on β-cells of pancreas in diabetic rats. The current study revealed the antidiabetic potential of Artemisia amygdalina being effective in hyperglycemia and that it can effectively protect against other metabolic aberrations caused by diabetes in rats, which seems to validate its therapeutic traditional use.

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Pharmacological characterization of different fractions of Calotropis procera (Asclepiadaceae) in streptozotocin induced experimental model of diabetic neuropathy

Cited by 29 publications

References 32 publications

Antidiabetic activities of aqueous ethanol and n-butanol fraction of Moringa stenopetala leaves in streptozotocin-induced diabetic rats

Antidiabetic activities of aqueous ethanol and n-butanol fraction of Moringa stenopetala leaves in streptozotocin-induced diabetic rats

Antidiabetic, antioxidant and anti inflammatory properties of water and n-butanol soluble extracts from Saharian Anvillea radiata in high-fat-diet fed mice

Antidiabetic Activity ofArtemisia amygdalinaDecne in Streptozotocin Induced Diabetic Rats

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