Pharmacological basis for the medicinal use of <i>Morus alba</i> in gut and airways disorders

Functional nature of the spasmolytic effect, phytochemical composition and acute toxicity studies on <i>Sauromatum guttatum</i>

“…The isolated tissue experiments were carried out as previously described (Gilani et al, 2005;Shah et al, 2011a;Khan et al, 2012). The animals had free access to water but were fasted for 24 hours before the experiment.…”

Studies on Bronchodilator Activity of Salvia officinalis (Sage): Possible Involvement of K+ Channel Activation and Phosphodiesterase Inhibition

“…The potency of the plant extract for its bronchodilator effect was greater (p < 0.05) as compared to that of aminophylline evident by three-times larger dose of aminophylline required to produce comparable response. In our earlier studies, we observed that the bronchodilatory effect of medicinal plants is usually mediated through K + channel opening Khan et al, 2012), PDE-inhibitory-like (Gilani et al, 2009;Rehman et al, 2012), and/or Ca ++ channel blockade (Janbaz et al, 2013;Shah and Gilani, 2012) pathways. To assess, whether the bronchodilatory effect of the crude extract of S. officinalis was also mediated through one or more such mechanism (s), it was tested on low K + , CCh, and high K + -induced contractions.…”

“…The test drug was given to the animals 5–8 min prior to administration of CCh. The responses were expressed as the percent reduction of the CCh‐induced bronchospasm (Khan et al, a).…”

Natural Products Useful in Respiratory Disorders: Focus on Side-Effect Neutralizing Combinations

“…It was reported to possess Ca ++ antagonist activity, which might be responsible for the bronchodilatory action (Ghayur and Gilani, 2006b;Ghayur et al, 2008), although additional mechanism(s) cannot be ruled out. Sarcococca saligna, Borago officinalis, Achillea millefolium, olives (Olea europea), cardamom (Elettaraia cardamomum), Swertia chirata, Desmostachya bipinnata, Tephrosia purpurea and Polygonatum verticillatum were also found to exhibit CCB effect, which may account for their bronchodilatory potential (Ghayur and Gilani, 2006a;Gilani et al, 2007, Khan and Gilani, 2011a, 2011bKhan et al, 2011;Khan et al, 2012d;Abdur Rahman et al, 2013;Janbaz et al, 2013;Khan et al, 2013aKhan et al, , 2013b, and it would not be surprising to see co-existence of other pharmacological mechanisms in future studies.…”