Pharmacological Basis For Antianaphylactic, Antihistaminic And Mast Cell Stabilization Activity Of Ocimum Sanctum

Sridevi, G.; Gopkumar, P; Ashok, Shenoy; Shastry, C. S.

doi:10.5580/bc4

Cited by 3 publications

(2 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similar activities were displayed by the aqueous extract of species Perilla frutescens (Shin et al, 2000), Phlomis umbrosa (Shin et al, 2008), Salvia plebeia (Shin and Kim, 2002), Schizonepeta tenuifolia (Shin et al, 1999) and Teucrium japonicum aqueous extract (Kim et al, 2009). Sridevi et al (2009) highlighted that the ethanolic extract of Ocimum sanctum at 400 mg/kg effectively reduced mortality (41%) due to anaphylactic shock-induced bronchospasm in tested subjects with a significant drop (P < 0.001) in serum IgE level to 25.80 ± 4.85 ng/ml (P < 0.001), as compared to sensitized control (125.06 ± 9.66 ng/ml). These findings confirm that the anti-allergic potential of O. sanctum is worthwhile to be further explored.…”

Section: Inhibition Of Allergen-specific Igementioning

confidence: 96%

Lamiaceae: An Insight on Their Anti-Allergic Potential and Its Mechanisms of Action

2019

View full text Add to dashboard Cite

The prevalence of allergic diseases such as asthma, allergic rhinitis, food allergy and atopic dermatitis has increased dramatically in recent decades. Conventional therapies for allergy can induce undesirable effects and hence patients tend to seek alternative therapies like natural compounds. Considering the fact above, there is an urgency to discover potential medicinal plants as future candidates in the development of novel anti-allergic therapeutic agents. The Lamiaceae family, or mint family, is a diverse plant family which encompasses more than 7,000 species and with a cosmopolitan distribution. A number of species from this family has been widely employed as ethnomedicine against allergic inflammatory skin diseases and allergic asthma in traditional practices. Phytochemical analysis of the Lamiaceae family has reported the presence of flavonoids, flavones, flavanones, flavonoid glycosides, monoterpenes, diterpenes, triterpenoids, essential oil and fatty acids. Numerous investigations have highlighted the anti-allergic activities of Lamiaceae species with their active principles and crude extracts. Henceforth, this review has the ultimate aim of compiling the up-to-date (2018) findings of published scientific information about the anti-allergic activities of Lamiaceae species. In addition, the botanical features, medicinal uses, chemical constituents and toxicological studies of Lamiaceae species were also documented. The method employed for data collection in this review was mainly the exploration of the PubMed, Ovid and Scopus databases. Additional research studies were obtained from the reference lists of retrieved articles. This comprehensive summarization serves as a useful resource for a better understanding of Lamiaceae species. The anti-allergic mechanisms related to Lamiaceae species are also reviewed extensively which aids in future exploration of the anti-allergic potential of Lamiaceae species.

show abstract

Section: Inhibition Of Allergen-specific Igementioning

confidence: 96%

Lamiaceae: An Insight on Their Anti-Allergic Potential and Its Mechanisms of Action

2019

View full text Add to dashboard Cite

show abstract

“…Several pharmacological investigations supported some of the traditional claims for O. tenuiflorum. For instance, in line with its presumed usefulness against asthma and related conditions, a leaf extract displayed anti-anaphylactic, antihistaminic, and mast cell-stabilizing activities in laboratory rodents [273]. Indications for its anti-inflammatory, analgesic, and antipyretic activities came from the inhibitory effects in laboratory animals of the non-volatile oil from leaf and seed on formaldehyde-, carrageenan-, inflammatory mediators-, or turpentine oil-induced arthritis, paw edema, and joint edema [274][275][276]; acetic acid-induced tail flicking, tail clipping, tail immersion, and writhing [277]; and typhoid-paratyphoid A/B vaccine-provoked pyrexia [277].…”

Section: Lamiaceae-ocimum Tenuiflorum Lmentioning

confidence: 96%

Traditional Plant-Based Treatments of Fungal Infections in the Republic of Suriname (South America): Phytochemical and Pharmacological Rationales

Mans¹

2022

Traditional Plant-Based Forms of Treatment of Fungal Infections in Suriname - Phytochemical and Pharmacological Rationale

View full text Add to dashboard Cite

Fungi are unicellular or multicellular thick-walled eukaryotic organisms that are not capable of photosynthesis and are placed in a biological kingdom of their own. They are ubiquitous in our environment, and include tens of thousands, perhaps even millions of species of yeasts, rusts, smuts, mildews, molds, and mushrooms. Together with bacteria, fungi are the principal decomposers of plant materials such as cellulose and lignin, fulfilling vital ecological functions in all terrestrial habitats. Some species of fungi are also of major importance in households (for instance, as foods such as edible mushrooms), medicine (for instance, as producers of antibiotics such as penicillin), and industry (for instance, for making bread, wine, and cheese). About 300 fungal species cause infections in humans, varying from relatively harmless skin complaints such as pityriasis versicolor to potentially life-threatening systemic syndromes such as candidiasis. Fortunately, a broad armamentarium of efficacious antifungal drugs has been developed, ranging from topical nystatin to parenteral amphotericin B. In addition, most, if not all traditional medical systems throughout the world have identified a large assortment of plant-based remedies for treating these infections. This also holds true for the multi-ethnic and multicultural Republic of Suriname (South America), where plant-based traditional medicines are abundantly used, either alone or in conjunction with allopathic medications. This monograph extensively addresses nine plants that are traditionally used for treating fungal infections in Suriname, and explains the phytochemical and pharmacological rationales for these applications. These sections are preceded by some general observations about the Fungal Kingdom; a few words about the characteristics of fungi, their taxonomy, and their significance to humans; information about fungal infections as well as the available forms of treatment; and some details about Suriname including health aspects, the health care structure, and the main fungal infections in the country. The monograph is concluded with an evaluation of the status of the Surinamese herbal antifungal substances and the previsions of developing them into mainstream antifungal formulations.

show abstract

QSAR Model for Mast Cell Stabilizing Activity of Indolecarboxamidotetrazole Compounds on Human Basophils

Basu¹,

Sarkar

Basak

2017

Communications in Computer and Information Science

View full text Add to dashboard Cite

Pharmacological Basis For Antianaphylactic, Antihistaminic And Mast Cell Stabilization Activity Of Ocimum Sanctum

Cited by 3 publications

References 3 publications

Lamiaceae: An Insight on Their Anti-Allergic Potential and Its Mechanisms of Action

Lamiaceae: An Insight on Their Anti-Allergic Potential and Its Mechanisms of Action

Traditional Plant-Based Treatments of Fungal Infections in the Republic of Suriname (South America): Phytochemical and Pharmacological Rationales

QSAR Model for Mast Cell Stabilizing Activity of Indolecarboxamidotetrazole Compounds on Human Basophils

Contact Info

Product

Resources

About