Pharmacological aspects of Co(II), Ni(II) and Cu(II) schiff base complexes: An insight

Alka, .; Gautam, Shweta; Kumar, Rajesh; Singh, Prashant; Gandhi, Namita; Jain, Pallavi

doi:10.1016/j.rechem.2023.100849

Cited by 8 publications

(3 citation statements)

References 80 publications

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“…Additionally, they can act as structural templates that influence the folding of proteins. 16,17 Schiff bases have a wide range of applications in organic synthesis and catalysis, 18 antitumor 19,20 anticancer, 21,22 antibacterial, [23][24][25][26] antifungal, 27,28 cytotoxic activity, 29 antiviral, 17 and others. [18][19][20] Researchers are particularly interested in Schiff base ligands due to their ease of synthesis, 30 as they are commonly used to synthesize complexes based on transition metals.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, structural investigations, in vitro cytotoxicity, apoptotic activity, cell cycle analysis, and molecular modeling studies of nano‐sized Zn(II) Schiff base complex

Amri,

Alaghaz

2024

Applied Organom Chemis

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A new novel tetradentate ligand, [(1E,1′E)‐N,N′‐(1,2‐phenylene)bis(1‐(5‐(2‐fluorophenyl)furan‐2‐yl)methanimine) (PFPFMI), and its nano‐sized [Zn(PFPFMI)Cl2].3H2O complex were synthesized. The geometry of PFPFMI and its Zn(II) complex was described through CHN analyses, Fourier‐transform infrared spectroscopy (FTIR), UV–visible, X‐ray diffraction (XRD), thermal gravimetric analysis (TGA), and mass spectral data tests. The spectral data of the nano‐sized [Zn(PFPFMI)Cl2].3H2O complex indicates that the PFPFMI ligand functions as a tetradentate (N2O2) coordination through two azomethine nitrogen groups (N) and two furan ring oxygen (O) atoms. Density functional theory (DFT) calculations were performed using the molecular studio software to investigate the optimal geometry of PFPFMI and its [Zn(PFPFMI)Cl2].3H2O complex. The SEM, TEM, XRD, AFM, and energy dispersive X‐ray analysis (EDX) analyses of the studied complex unveil distinct and strong diffraction peaks, indicating its crystalline nature and providing evidence of its nano‐sized particle sizes. Additionally, the inhibition zone diameter was used to assess the in vitro antimicrobial action of PFPFMI and the particular complex against Gram‐positive bacteria Streptococcus pneumonia and Bacillus subtilis, Gram‐negative bacteria Pseudomonas aeruginosa, Salmonella typhi, and Escherichia coli, as well as fungi Aspergillus fumigatus, Geotricum candidum, Syncephalastrum racemosum, and Candida tropicalis. The [Zn(PFPFMI)Cl2].3H2O complex exhibits higher activity than the ligand PFPFMI. In vitro cytotoxicity of the synthesized [Zn(PFPFMI)Cl2].3H2O complex was explored using MCF7 (breast cancer), HCT116 (colon cancer), A549 (lung cancer), HePG‐2 (liver cancer), A375 (melanoma cancer), and normal lung fibroblast (WI38) cell lines. Based on IC50 and selective index (SI) values, it was shown that the complex exhibited higher potency against MCF7 cell lines. Moreover, the Zn(II) complex exhibited the ability to induce DNA damage in MCF7 cells, resulting in dose‐dependent cell apoptosis. Subsequent investigations revealed that complex 2 also induced cell cycle arrest in the G2 and S phases.

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Section: Introductionmentioning

confidence: 99%

Synthesis, structural investigations, in vitro cytotoxicity, apoptotic activity, cell cycle analysis, and molecular modeling studies of nano‐sized Zn(II) Schiff base complex

Amri,

Alaghaz

2024

Applied Organom Chemis

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“…The structural motifs of aroyl hydrazone have been verified by their multifunctional potential in drug-design, favourable catalytic, and ultratrace detection of elements in biological samples [1][2][3]. In recent years, there is an enhanced interest in the chemistry of hydrazones and their complexes due to their wide range of antidepressant [4], antibacterial, antiviral, antifungal, analgesic, anti-inflammatory, anticonvulsant, antimalarial activities [5,6]. The nucleophilic imine, amino nitrogen, imine carbon (electrophilic and nucleophilic nature), and intrinsic character of (>C N-) bond [7] in the structure and functional diversity of aroyl hydrazone ligands are potentially responsible for their pharmacological as well as biological potentials viz., tuberculosis, antitumoral [8,9] anticoagulant, antiplatelet [10], and enzymatic inhibitors [11].…”

Section: Introductionmentioning

confidence: 99%

“…13 C-NMR (DMSO-d6 , 500MHz, δ ppm): 207.78(carbon of C = O), 160 (phenyl-C), amide group), 145(azomethine-C), 119 (C11), 131(C12), 118(C13), 126.8 (C14), 127(C15), 128 (C16), 130(C17), 135(C18). HRMS (ESI-Mass m/z): Calc.…”

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confidence: 99%

New aroyl heterocyclic (E)-N′-((2-hydroxynaphthalen-1-yl)methylene)-4-oxopiperidine-1-carbohydrazide and its metal complexes: synthesis, spectroscopic, thermal, DFT, molecular docking and antimicrobial studies

Dongare,

Aswar

2023

Res Chem Intermed

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In order to resist the growth of human pathogenic microorganisms, we have synthesized a new N-heterocyclic hydrazone ligand of (E)-N'-(2-hydroxynaphthalen-1-yl)methylene-4-oxopiperidine-1-carbohydrazide (H2L) from the condensation reaction of 4-oxo-1-carbopiperidone hydrazide and 2-hydroxy-1-naphthaldehyde. The ligand reacted with metal salt of (M(II/III).Cl2).nH2O formed the two types of complexes [M(III)C17H19N3O5Cl] and [M(II)C17H20N3O5Cl] adopted octahedral geometry; where M=Cr(III), Fe(III), Mn(II), Co(II), Ni(II), Cu(II) ion. The ligand was thoroughly characterized by elemental analysis, FT−IR, UV−Vis, NMR ( 1 H, 13 C), HR-mass spectroscopy. Furthermore, the structural properties of metal complexes have been established on the basis of elemental analysis, UV-vis spectra, molar conductivity, magnetic susceptibility, ESR, TG-DTA analysis. The ligand behaves dibasic, linkages via phenolic-O, azomethine-N, enolic-O atoms in metal (III) complexes and monobasic in metal(II) complexes. The decomposition pattern were ascertained by thermal analysis, and kinetics accountability from Coats-Redfern relation. The compounds were excited at λex = 380 nm and observed good emission intensity at λem = λ527-533 nm. The surface morphology of ligand was distinct from complex proven an imaging by SEM analysis. The molecular geometry optimization, and quantum chemical properties have been retrieved from DFT. ADMET score have been predicted as a drug-likeness prospect from admetSAR method. The molecular docking outcomes displayed the good binding score of ligand with Adenylate kinase, Peptide deformylase (bacterial enzyme) and DNA polymerase (fungal enzyme).The in vitro antimicrobial potency of ligand and its complexes were showed the promising activity against the bacterial colony (Escherichia coli, Salmonella typhi, Staphylococcus aureus, Bacillus substilis), and fungal colony (Candida albicans, Aspergillus niger).

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Novel amide based macrocyclic complexes of Co(II): Synthesis, structural characterization, thermal, DFT, molecular docking studies, in vitro cytotoxic, antimicrobial and antioxidant evaluation

Subhash,

Kumar,

Jyoti

et al. 2024

Journal of Molecular Structure

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Pharmacological aspects of Co(II), Ni(II) and Cu(II) schiff base complexes: An insight

Cited by 8 publications

References 80 publications

Synthesis, structural investigations, in vitro cytotoxicity, apoptotic activity, cell cycle analysis, and molecular modeling studies of nano‐sized Zn(II) Schiff base complex

Synthesis, structural investigations, in vitro cytotoxicity, apoptotic activity, cell cycle analysis, and molecular modeling studies of nano‐sized Zn(II) Schiff base complex

New aroyl heterocyclic (E)-N′-((2-hydroxynaphthalen-1-yl)methylene)-4-oxopiperidine-1-carbohydrazide and its metal complexes: synthesis, spectroscopic, thermal, DFT, molecular docking and antimicrobial studies

Novel amide based macrocyclic complexes of Co(II): Synthesis, structural characterization, thermal, DFT, molecular docking studies, in vitro cytotoxic, antimicrobial and antioxidant evaluation

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