Pharmacological approaches to ameliorating catabolic conditions

Elamin, Elamin M.; Glass, Maresa; Camporesi, Enrico

doi:10.1097/01.mco.0000232906.89662.bb

Cited by 6 publications

(3 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previously, melatonin has been reported to limit weight loss and improve status of cachectic patients with advanced cancer [24,25]. The present study confirms that melatonin restored the weight loss resulting from acute lung inflammation in SD (Fig.…”

Section: Discussionsupporting

confidence: 89%

Melatonin attenuates lipopolysaccharide‐induced acute lung inflammation in sleep‐deprived mice

Lee

Kim

Lee

et al. 2008

Journal of Pineal Research

View full text Add to dashboard Cite

Sleep disorders are great problems in modern society. Even minimal changes of sleep can affect health. Especially, patients with pulmonary diseases complain of sleep problems such as sleep disturbance and insomnia. Recent studies have shown an association between sleep deprivation (SD) and inflammation, however, the underlying mechanisms remain unclear. In the present study, we investigated whether melatonin protects against acute lung inflammation in SD. Male ICR mice were deprived sleep using modified multiplatform water bath for 3 days. Acute lung inflammation was induced by lipopolysaccharide (LPS; 5 mg/kg). Melatonin (5 mg/kg) and LPS was administered in SD mice at day 2. Mice were divided into five groups as control, SD, LPS, LPS + SD, and LPS + SD + melatonin (each group, n = 11). Mice were killed on day 3 after treatment of melatonin and LPS for 24 hr. Lung tissues were collected for histological examination and protein analysis. The malondialdehyde (MDA) level was determined for the effect of oxidative stress. Melatonin restored weight loss in LPS + SD. Histological findings revealed alveolar damages with inflammatory cell infiltration in LPS + SD. Melatonin remarkably attenuated the alveolar damages. In western blot analysis, LPS reduced the levels of Bcl-XL and procaspase-3 in SD mice. After treatment with melatonin, the levels of Bcl-XL and procaspase-3 increased when compared with LPS + SD. LPS treatment showed an increase of TUNEL-positive cells, whereas melatonin prevented the increase of cell death in LPS + SD animals. In lipid peroxidation assay, melatonin significantly reduced the elevated MDA level in LPS + SD. Our results suggest that melatonin attenuates acute lung inflammation during SD via anti-apoptotic and anti-oxidative actions.

show abstract

Section: Discussionsupporting

confidence: 89%

Melatonin attenuates lipopolysaccharide‐induced acute lung inflammation in sleep‐deprived mice

Lee

Kim

Lee

et al. 2008

Journal of Pineal Research

View full text Add to dashboard Cite

show abstract

“…The understanding of the signal transduction and metabolic pathways associated with cancer cachexia has opened several areas of potential as well as active investigation to help patients suffering from this syndrome (Table 4). Current therapies focus on affecting the hunger pathways with goals of increasing appetite and inhibiting catabolic factors 94 . One approach to increasing appetite is to modify hypothalamic‐derived signals to suppress cachexia.…”

Section: The Clinical Syndromes Resulting From the Growth Of Metastatmentioning

confidence: 99%

“…Current therapies focus on affecting the hunger pathways with goals of increasing appetite and inhibiting catabolic factors. 94 One approach to increasing appetite is to modify hypothalamic-derived signals to suppress cachexia. The best-known agents of this type are megestrol and medroxyprogesterone acetate.…”

Section: Cachexiamentioning

confidence: 99%

The Lethal Phenotype of Cancer: The Molecular Basis of Death Due to Malignancy

Loberg

Bradley

Tomlins

et al. 2007

CA: A Cancer Journal for Clinicians

145

134

View full text Add to dashboard Cite

The last decade has seen an explosion in knowledge of the molecular basis and treatment of cancer. The molecular events that define the lethal phenotype of various cancersthe genetic and cellular alterations that lead to a cancer with a poor or incurable prognosisare being defined. While these studies describe the cellular events of the lethal phenotype of cancer in detail, how these events result in the common clinical syndromes that kill the majority of cancer patients is not well understood. It is clear that the central step that makes most cancers incurable is metastasis. Understanding the traits that a cancer acquires to successfully grow and metastasize to distant sites gives insight into how tumors produce multiple factors that result in multiple different clinical syndromes that are lethal for the patient. (CA Cancer J Clin 2007;57:225-241.)

show abstract

Cancer-Related Weight Loss

Ottery

2009

Palliative Medicine

View full text Add to dashboard Cite

Pharmacological approaches to ameliorating catabolic conditions

Abstract: Information from this review will guide health care providers in limiting weight loss and improving performance status of cachectic patients through pharmacological therapy, with the hope that such therapy will extend patients' survival and improve their qualities of life.

Cited by 6 publications

References 32 publications

Melatonin attenuates lipopolysaccharide‐induced acute lung inflammation in sleep‐deprived mice

Melatonin attenuates lipopolysaccharide‐induced acute lung inflammation in sleep‐deprived mice

The Lethal Phenotype of Cancer: The Molecular Basis of Death Due to Malignancy

Cancer-Related Weight Loss

Contact Info

Product

Resources

About