Pharmacological applications of inorganic complexes

Bakhtiar, Ray; Ochiai, Ei-Ichiro

doi:10.1016/s0306-3623(98)00223-7

Cited by 71 publications

(43 citation statements)

References 77 publications

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“…Bioinorganic agents have emerged as powerful therapies to treat a wide variety of medical disorders [47][48][49]. However, the medical application of metallic ions may present specific problems of acute local and systemic toxicity, particularly in the case of copper which has a very narrow therapeutic range for in vivo applications (see Table 1).…”

Section: Potential Applications and Outlookmentioning

confidence: 99%

Dissolution of copper mineral phases in biological fluids and the controlled release of copper ions from mineralized alginate hydrogels

Bassett¹,

Madzovska²,

Beckwith³

et al. 2014

Biomed. Mater.

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Here we investigate the dissolution behaviour of copper minerals contained within biocompatible alginate hydrogels. Copper has a number of biological effects and has most recently been evaluated as an alternative to expensive and controversial growth factors for applications in tissue engineering.Precise control and sustained release of copper ions are important due to a narrow therapeutic window of this potentially toxic ion, and alginate would appear to be a good material of choice for this purpose. We found that aqueously insoluble copper minerals could be precipitated during gelling within or mixed into alginate hydrogels in the form of microbeads prior to gelling to serve as depots of copper. These minerals were found to be soluble in a variety of biological fluids relevant to in vitro and in vivo investigations, and the alginate carrier served as a barrier to diffusion of these ions and therefore offered control over the rate and duration of release (Cu 2+ release rates observed between 10 -750 µMol g -1 h -1 and duration for up to 32 days). Copper mineral and copper mineralized alginate microbeads were characterized using powder x-ray diffraction, FTIR, thermogravimetric analysis and scanning electron microscopy. Dissolution kinetics were studied to determine copper ion concentrations using colourimetric methods. In addition we characterised the complexes formed between released copper ions and biological fluids by electron paramagnetic spectroscopy which offers an insight into the behaviour of these materials in the body.

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Section: Potential Applications and Outlookmentioning

confidence: 99%

Dissolution of copper mineral phases in biological fluids and the controlled release of copper ions from mineralized alginate hydrogels

Bassett¹,

Madzovska²,

Beckwith³

et al. 2014

Biomed. Mater.

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“…There are several pharmacological applications of vanadium including treatment of diabetes , cancer therapy (Chakraborty et al 2007;Bakhtiar and Ochiai 1999), anti-inflammatory activity (Thompson and Orvig 2001), hypertension and obesity (Hopfner et al 1998). Studies in human beings have shown that vanadyl sulfate supplements normalize blood glucose levels and reduced HbA1c levels (Boden et al 1996) in patients with noninsulin-dependent diabetes mellitus (NIDDM).…”

Section: Introductionmentioning

confidence: 99%

Influence of vanadium supplementation on oxidative stress factors in the muscle of STZ-diabetic rats

Kurt¹,

Yilmaz-Ozden²,

Özsoy³

et al. 2011

Biometals

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In recent years, the role of free radical damage consequent to oxidative stress is widely discussed in diabetic complications. In this aspect, the protection of cell integrity by trace elements is a topic to be investigated. Vanadium is a trace element believed to be important for normal cell function and development. The aim of the present study was to investigate the effect of vanadyl sulfate supplementation on the antioxidant system in the muscle tissue of diabetic rats. Diabetes was induced by intraperitoneal injection of streptozotocin (STZ, 65 mg/kg body weight) to male Swiss albino rats. The rats were randomly divided into 4 groups: Group I, control; Group II, vanadyl sulfate control; Group III, STZ-diabetic untreated; Group IV, STZ-diabetic treated with vanadyl sulfate. Vanadyl sulfate (100 mg/kg) was given daily by gavage for 60 days. At the last day of the experiment, rats were killed, muscle tissues were taken, homogenized in cold saline to make a 10% (w/v) homogenate. Body weights and blood glucose levels were estimated at 0, 30 and 60th days. Antioxidant enzymes, superoxide dismutase (SOD), catalase (CAT), glutathione reductase (GR), glutathione peroxidase (GPx), glutathione-S-transferase (GST), as well as carbonic anhydrase (CA), myeloperoxidase (MPO) activities and protein carbonyl content (PCC) were determined in muscle tissue. Vanadyl sulfate administration improved the loss in body weight due to STZ-induced diabetes and decreased the rise in blood glucose levels. It was shown that vanadium supplementation to diabetic rats significantly decrease serum antioxidant enzyme levels, which were significantly raised by diabetes in muscle tissue showing that this trace element could be used as preventive for diabetic complications.

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“…It is well known that metal ions play a vital role in a vast of widely different biological processes and most of the biologically active compounds act via chelation. Inorganic and bioinorganic compounds, as well as their applications in medicine, have attracted the attention of scientists in order to advance in the investigations on cancer chemotherapy and chemoprevention, antiarthritis compounds and antimicrobials agents (Williams 1972;Cameron 2001;Bakhtiar and Ochiai 1999;Taylor and Williams 1995). By using methimazole as a chelating ligand, several metal-coordination complexes have been synthesized (Raper 1996(Raper , 1997Raper and Brooks 1997) including mercury compounds as potential protective agents in organomercurial intoxication in the detoxification area (Buncel et al 1982).…”

Section: Introductionmentioning

confidence: 99%

Copper(II) complexes of methimazole, an anti Grave’s disease drug. Synthesis, characterization and its potential biological behavior as alkaline phosphatase inhibitor

et al. 2009

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Methimazole (MeimzH) is an anti-thyroid drug and the first choice for patients with Grave's disease. Two new copper(II) complexes of this drug: [Cu(MeimzH)(2)(NO(3))(2)]*0.5H(2)O and [Cu(MeimzH)(2)(H(2)O)(2)](NO(3))(2)*H(2)O were synthesized and characterized by elemental analysis, dissolution behavior, thermogravimetric analysis and UV-vis, diffuse reflectance, FTIR and EPR spectroscopies. As it is known that copper(II) cation can act as an inhibitor of alkaline phosphatase (ALP), the inhibitory effect of methimazole and its copper(II) complexes on ALP activity has also been investigated.

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Pharmacological applications of inorganic complexes

Cited by 71 publications

References 77 publications

Dissolution of copper mineral phases in biological fluids and the controlled release of copper ions from mineralized alginate hydrogels

Dissolution of copper mineral phases in biological fluids and the controlled release of copper ions from mineralized alginate hydrogels

Influence of vanadium supplementation on oxidative stress factors in the muscle of STZ-diabetic rats

Copper(II) complexes of methimazole, an anti Grave’s disease drug. Synthesis, characterization and its potential biological behavior as alkaline phosphatase inhibitor

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