Pharmacological antagonism of Ccr2+ cell recruitment to facilitate regenerative tendon healing
Gilbert Smolyak,
Andrew Rodenhouse,
Anne E. C. Nichols
et al.
Abstract:Successful tendon healing requires sufficient deposition and remodeling of new extracellular matrix at the site of injury, with this process mediating in part through fibroblast activation via communication with macrophages. Moreover, resolution of healing requires clearance or reversion of activated cells, with chronic interactions with persistent macrophages impairing resolution and facilitating the conversion to fibrotic healing. As such, modulation of the macrophage environment represents an important tran… Show more
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