2014
DOI: 10.2147/ijn.s59172
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Pharmacological and toxicological effects of co-exposure of human gingival fibroblasts to silver nanoparticles and sodium fluoride

Abstract: Background Silver nanoparticles (AgNPs) and fluoride (F) are pharmacological agents widely used in oral medicine and dental practice due to their anti-microbial/anti-cavity properties. However, risks associated with the co-exposure of local cells and tissues to these xenobiotics are not clear. Therefore, we have evaluated the effects of AgNPs and F co-exposure on human gingival fibroblast cells. Methods Human gingival fibroblast cells (CRL-2014) were exposed to AgNPs an… Show more

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Cited by 46 publications
(37 citation statements)
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“…The increase in AST (aspartate aminotransferase) may be due to fluoxetine hepatotoxicity, as fluoxetine is extensively metabolized in the liver to norfluoxetine and this is a well-known side effect (Inkielewicz-Stepniak et al, 2014 ). Fluoxetine may also induce moderate lymphocyte infiltration within the portal tracts and ballooning degeneration of hepatocytes (Kwak et al, 2000 ).…”
Section: Discussionmentioning
confidence: 99%
“…The increase in AST (aspartate aminotransferase) may be due to fluoxetine hepatotoxicity, as fluoxetine is extensively metabolized in the liver to norfluoxetine and this is a well-known side effect (Inkielewicz-Stepniak et al, 2014 ). Fluoxetine may also induce moderate lymphocyte infiltration within the portal tracts and ballooning degeneration of hepatocytes (Kwak et al, 2000 ).…”
Section: Discussionmentioning
confidence: 99%
“…The same membrane was stripped and β-actin (Sigma Aldrich) was used as an internal control. Western blotting analysis and protein bands quantification was performed as previously reported by our group [ 22 , 35 ].…”
Section: Methodsmentioning
confidence: 99%
“…Then, DNA-free RNA from samples were reverse-transcribed using a high-capacity cDNA reverse transcription kit (Applied Biosystems, UK). RT-PCR as well as quantitative analysis was conducted as previously reported by our group [ 22 , 29 , 36 ].…”
Section: Methodsmentioning
confidence: 99%
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“…62,63 It is possible that the salivary proteins in oral cavity may also form a corona on the SNPs, which would have an effect on both the bactericidal effects (via ionic Ag dissolution) and cellular effects. Therefore, the interaction of SNPs or silver ions with the other compounds and elements in human saliva should be better evaluated, 64 especially as the increased production of materials containing nanoparticles presents an important toxicological concern. 65,66 The results obtained in the present study showed that the materials modified with SNPs have a time-limited ion release.…”
mentioning
confidence: 99%