Pharmacological and Therapeutic Aspects of Plants from the Genus Ferula: A Comprehensive Review

Sabzehzari, Mohammad; Naghavi, Mohammad Reza; Bozari, Motahare; Orafai, Hossein; Johnston, Thomas P.; Sahebkar, Amirhossein

doi:10.2174/1389557520666200505125618

Cited by 11 publications

(1 citation statement)

References 156 publications

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“…Furthermore, it exhibits free- radical-scavenging activity. Enzymes [ 153 , 154 ] Acanthopanax trifoliatus and Eleutherococcus senticosus (Araliaceae) Whole Plant extract Polyphenols, flavonoids It inhibits lipid peroxidation and also scavenges the free radicals in the rat brain. Stress markers [ 155 ] Sarcococca saligna (Buxaceae) Whole plant extracts Salignenamide-E, 2-hydroxysalignar ine-E, axillaridine-A It increases the ACh level by inhibiting AChE and BChE.…”

Section: Current Neurotherapeutics For Admentioning

confidence: 99%

Review of Pharmacotherapeutic Targets in Alzheimer’s Disease and Its Management Using Traditional Medicinal Plants

Tripathi,

Lodhi,

Rai

et al. 2024

DNND

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Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline, memory loss, and impaired daily functioning. While there is currently no cure for AD, several pharmacotherapeutic targets and management strategies have been explored. Additionally, traditional medicinal plants have gained attention for their potential role in AD management. Pharmacotherapeutic targets in AD include amyloid-beta (Aβ) aggregation, tau protein hyperphosphorylation, neuroinflammation, oxidative stress, and cholinergic dysfunction. Traditional medicinal plants, such as Ginkgo biloba, Huperzia serrata, Curcuma longa (turmeric), and Panax ginseng, have demonstrated the ability to modulate these targets through their bioactive compounds. Ginkgo biloba , for instance, contains flavonoids and terpenoids that exhibit neuroprotective effects by reducing Aβ deposition and enhancing cerebral blood flow. Huperzia serrata , a natural source of huperzine A, has acetylcholinesterase-inhibiting properties, thus improving cholinergic function. Curcuma longa , enriched with curcumin, exhibits anti-inflammatory and antioxidant effects, potentially mitigating neuroinflammation and oxidative stress. Panax ginseng’s ginsenosides have shown neuroprotective and anti-amyloidogenic properties. The investigation of traditional medicinal plants as a complementary approach to AD management offers several advantages, including a lower risk of adverse effects and potential multi-target interactions. Furthermore, the cultural knowledge and utilization of these plants provide a rich source of information for the development of new therapies. However, further research is necessary to elucidate the precise mechanisms of action, standardize preparations, and assess the safety and efficacy of these natural remedies. Integrating traditional medicinal-plant-based therapies with modern pharmacotherapies may hold the key to a more comprehensive and effective approach to AD treatment. This review aims to explore the pharmacotherapeutic targets in AD and assess the potential of traditional medicinal plants in its management.

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