Pharmacological and Pharmacokinetic Studies with Vitamin D-loaded Nanoemulsions in Asthma Model

Wei-hong, Tang; Min-chang, Guan; Xu, Zhiyong; Sun, Jin

doi:10.1007/s10753-013-9790-0

Cited by 14 publications

(5 citation statements)

References 26 publications

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“…A higher serum MPO level is associated with the systemic inflammation related to CV disease 80 and vitamin D3 treatment significantly reduced MPO. 81 This may refer to its important inhibitory influence on this inflammatory pathway. 82…”

Section: Discussionmentioning

confidence: 99%

Early myocardial injury biomarkers in diabetic hyperlipidemic rats: Impact of 10-dehydrogingerdione and vitamin D3

Elseweidy

Aly

Hammad

et al. 2020

Exp Biol Med (Maywood)

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Hyperlipidemia represents a major risk factor for cardiovascular diseases leading to myocardial injury. The present study aimed to illustrate the myocardial injury induced in a diabetic hyperlipidemic rat model and the effect of vitamin D3, 10-DHGD intake either individually or in combination form. Male albino rats were selected for the study, received alloxan, hypercholesterolemic diet, and categorized into four groups. The first one (DHC), received hypercholesterolemic diet only and referred to as control. The remaining groups (2, 3, 4) received vitamin D3, 10-DHGD, and combination of both, respectively. Certain biomarkers that were selected for MI evaluation included blood glucose, lipogram pattern, Copeptin, C-reactive protein, myeloperoxidase, heart fatty acid-binding protein, and histopathological changes in myocardium and aorta. Vitamin D3 and 10-DHGD intake induced significant hypoglycemic, hypolipidemic effects, decreased inflammation, and MI biomarkers. Decreased myocardial vacuoles, foam cells, and intimal lesions were also observed compared to DHC. Their combination intake induced more marked reduction in all biomarkers and showed a histopathological pattern similar to normal features of myocardium and aorta. Our findings suggest the therapeutic roles of vitamin D3, 10-DHGD, and their combination against myocardial injury in diabetic hyperlipidemic rats. Impact statement Hyperlipidemia represents a major risk factor for cardiovascular diseases leading to myocardial injury (MI). The present study aimed to illustrate the pattern of myocardial injury induced in diabetic hyperlipidemic rat model and the effect of vitamin D3, 10-dehydrogingerdione (10-DHGD) intake either individually or in combination form.

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Section: Discussionmentioning

confidence: 99%

Early myocardial injury biomarkers in diabetic hyperlipidemic rats: Impact of 10-dehydrogingerdione and vitamin D3

Elseweidy

Aly

Hammad

et al. 2020

Exp Biol Med (Maywood)

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“…In this study, the absorption capacity of Aerosil 200, a colloidal silica, which has been adopted as one of the most commonly used solid carriers in previous studies, 8,[26][27][28] was also measured. When the ratio of Aerosil 200 to liquid SEDDS increased from 1:1 to 1:2 (w/w), the powdered solid samples were changed to sticky aggregates.…”

Section: Preparation Of Ssedds Matrixmentioning

confidence: 99%

Supersaturable solid self-microemulsifying drug delivery system: precipitation inhibition and bioavailability enhancement

Quan¹,

Niu²,

Singh³

et al. 2017

IJN

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Solid self-emulsifying drug delivery system (SSEDDS), which incorporates liquid SEDDS into a solid dosage form, has been recently introduced to improve the oral bioavail-ability of poorly water-soluble drugs. However, supersaturated drug generated by SSEDDS is thermodynamically unstable and tends to precipitate rapidly prior to absorption, resulting in compromised bioavailability. The aim of this study was to construct a novel supersaturated SSEDDS (super-SSEDDS) by combining SSEDDS with appropriate precipitation inhibitor. Fenofibrate (FNB), a sparingly soluble drug, was selected as a model drug in this study. An optimized SSEDDS was prepared by solvent evaporation by using mesoporous silica Santa Barbara Amorphous-15 as the inert carrier. Supersaturation assay was conducted to evaluate the precipitation inhibition capacity of different polymers, and the results showed that Soluplus ® could retard the FNB precipitation more effectively and sustain a higher apparent concentration for ~120 min. This effect was also clearly observed in the dissolution profiles of FNB from SSEDDS under supersaturated condition. The study of the mechanism suggested that the inhibition effect might be achieved both thermodynamically and kinetically. The area under the concentration–time curve of the super-SSEDDS was 1.4-fold greater than that of SSEDDS in the absence of Soluplus, based on an in vivo pharmacokinetic study conducted in beagle dogs. This study has demonstrated that the approach of combining SSEDDS with Soluplus as a supersaturation stabilizer constitutes a potential tool to improve the absorption of poorly water-soluble drugs.

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“…The observed protective effect of VD on oxidant forces is consistent with existing data in the literature. One study reported that oral VD nanoemulsion therapy decreased oxidant species' activity in the serum of mice with airway inflammation [51]. In another study, VD decreased ROS when added to human bronchial epithelial cell culture, thus alleviating lipopolysaccharide-induced oxidative stress [52].…”

Section: Discussionmentioning

confidence: 99%

Vitamin D Supplementation: Oxidative Stress Modulation in a Mouse Model of Ovalbumin-Induced Acute Asthmatic Airway Inflammation

Adam-Bonci

Bonci

Pârvu

et al. 2021

IJMS

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Asthma oxidative stress disturbances seem to enable supplementary proinflammatory pathways, thus contributing to disease development and severity. The current study analyzed the impact of two types of oral vitamin D (VD) supplementation regimens on the redox balance using a murine model of acute ovalbumin-induced (OVA-induced) asthmatic inflammation. The experimental prevention group received a long-term daily dose of 50 µg/kg (total dose of 1300 µg/kg), whereas the rescue group underwent a short-term daily dose of 100 µg/kg (total dose of 400 µg/kg). The following oxidative stress parameters were analyzed in serum, bronchoalveolar lavage fluid (BALF) and lung tissue homogenate (LTH): total oxidative status, total antioxidant response, oxidative stress index, malondialdehyde and total thiols. Results showed that VD significantly reduced oxidative forces and increased the antioxidant capacity in the serum and LTH of treated mice. There was no statistically significant difference between the two types of VD supplementation. VD also exhibited an anti-inflammatory effect in all treated mice, reducing nitric oxide formation in serum and the expression of nuclear factor kappa B p65 in the lung. In conclusion, VD supplementation seems to exhibit a protective role in oxidative stress processes related to OVA-induced acute airway inflammation.

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Pharmacological and Pharmacokinetic Studies with Vitamin D-loaded Nanoemulsions in Asthma Model

Cited by 14 publications

References 26 publications

Early myocardial injury biomarkers in diabetic hyperlipidemic rats: Impact of 10-dehydrogingerdione and vitamin D3

Early myocardial injury biomarkers in diabetic hyperlipidemic rats: Impact of 10-dehydrogingerdione and vitamin D3

Supersaturable solid self-microemulsifying drug delivery system: precipitation inhibition and bioavailability enhancement

Vitamin D Supplementation: Oxidative Stress Modulation in a Mouse Model of Ovalbumin-Induced Acute Asthmatic Airway Inflammation

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