Pharmacological and pharmacokinetic effect of a polyherbal combination with Withania somnifera (L.) Dunal for the management of anxiety

Ganesan, R; Settu, Dinesh Kumar; Murkunde, Yogeshkumar; Chamundeeswari, D.

doi:10.1016/j.jep.2020.113337

Cited by 6 publications

(5 citation statements)

References 22 publications

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“…The anxiolytic effects of Po.Cr might be due to the presence of flavonoids, phenols, and terpenoids in Po.Cr extract. It has been indicated in a previous report that flavonoids and phenols found in natural medicinal plants are known to augment GABA A receptor neurotransmission in the brain and have additional antioxidant properties (Singh et al, 2012;Komaki et al, 2016;Muhasaparur Ganesan et al, 2021). Likewise, the Po.Cr treatment of diabetic rats attenuated depression-like symptoms, resulting in increased mobility in FST compared to untreated diabetic rats.…”

Section: Discussionmentioning

confidence: 97%

Hyperglycemia-associated Alzheimer’s-like symptoms and other behavioral effects attenuated by Plumeria obtusa L. Extract in alloxan-induced diabetic rats

et al. 2022

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Diabetes mellitus is a chronic metabolic complaint with numerous short- and long-term complications that harm a person’s physical and psychological health. Plumeria obtusa L. is a traditional medicine used in the treatment of diabetes to reduce complications related to behavior. Plumeria is a genus with antipsychotic activities. The objective of this study was to examine the effects of a methanolic extract of Plumeria obtusa L. in the attenuation of diabetes, on symptoms of Alzheimer disease, and on other associated behavioral aspects. A single dose of alloxan was administered to an experimental group of rats to induce development of diabetes (150 mg/kg, intraperitoneal) and the rats were then administered selected doses of methanolic extract of Plumeria obtusa L. (Po.Cr) or glibenclamide (0.6 mg/kg) for 45 consecutive days. Behavioral effects were evaluated using three validated assays of anxiety-related behavior: the open field test, the light and dark test, and the elevated plus maze. Anti-depressant effects of Plumeria obtusa L. were evaluated using the forced swim test (FST) and memory and learning were assessed using the Morris water maze (MWM) task. Po.Cr was also evaluated for phytochemicals using total phenolic content (TPC), total flavonoid content (TFC), and high-performance liquid chromatography assays, and antioxidant capability was assessed through assays of DPPH radical scavenging, total oxidation capacity, and total reducing capacity. In the alloxan-induced model of diabetes, the administration of Po.Cr and glibenclamide for 45 days produced a marked decrease (p < 0.001) in hyperglycemia compared to control animals. Po.Cr treatment also resulted in improvement in indicators, such as body weight and lipid profile (p < 0.05), as well as restoration of normal levels of alanine transaminase (ALT) (p < 0.001), a biomarker of liver function. Diabetic rats presented more Alzheimer-like symptoms, with greater impairment of memory and learning, and increased anxiety and depression compared to non-diabetic normal rats, whereas treated diabetic rats showed significant improvements in memory and behavioral outcomes. These results demonstrate that Po.Cr reversed alloxan-induced hyperglycemia and ameliorated Alzheimer-related behavioral changes, which supports additional study and assessment of conventional use of the plant to treat diabetes and associated behavioral complications.

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Section: Discussionmentioning

confidence: 97%

Hyperglycemia-associated Alzheimer’s-like symptoms and other behavioral effects attenuated by Plumeria obtusa L. Extract in alloxan-induced diabetic rats

et al. 2022

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“…The inclusion of behavioral experiments in the present study also revealed the presence of anxiety-like behavior in diabetic rats, as they remained in hidden and dark zones for a longer duration, but treatment with Aa.Cr provided protection against these psychological disorders. The flavonoids and polyphenols present in naturally occurring medicinal plants are reported to ameliorate anxiety-like behavior by modulating the expression of GABAergic transmission in the brain ( Komaki et al, 2016 , Muhasaparur Ganesan et al, 2021 ). Similarly, the rats treated with Aa.Cr showed dose-dependent protection from depression-like behavior, as they were more mobile in the forced swim test as compared to diabetic rats.…”

Section: Discussionmentioning

confidence: 99%

Chronically administered Agave americana var. marginata extract ameliorates diabetes mellitus, associated behavioral comorbidities and biochemical parameters in alloxan-induced diabetic rats

Aleem

Shahnaz²,

Javaid³

et al. 2022

Saudi Pharmaceutical Journal

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“…Plasma bioavailability and PK of withaferin A and withanolide A were recorded after intragastric administration of a WS root aqueous extract in mice [ 146 ]. Plasma bioavailability of withaferin A was also shown in rats after oral administration of a polyherbal formulation containing WS root [ 147 ]. Plasma PK of withanolide A was established in rats following oral administration of the compound, which also showed wide tissue distribution; notably, brain levels were considerably lower than in lung, kidney, liver, heart, and spleen [ 148 ].…”

Section: Discussionmentioning

confidence: 99%

Effects of Withania somnifera (Ashwagandha) on Stress and the Stress- Related Neuropsychiatric Disorders Anxiety, Depression, and Insomnia

Speers

Cabey

Soumyanath

et al. 2021

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Background: Withania somnifera (WS), also known as Ashwagandha, is commonly used in Ayurveda and other traditional medicine systems. WS has seen an increase in public use worldwide due to its reputation as an adaptogen. This popularity has elicited increased scientific study of its biological effects, including a potential application for neuropsychiatric and neurodegenerative disorders. Objective: This review aims to provide a comprehensive summary of preclinical and clinical studies examining the neuropsychiatric effects of WS, specifically its application in stress, anxiety, depression, and insomnia. Methods: Reports of human trials and animal studies of WS were collected primarily from the PubMed, Scopus, and Google Scholar databases. Results: WS root and leaf extracts exhibited noteworthy anti-stress and anti-anxiety activity in animal and human studies. WS also improved symptoms of depression and insomnia, though fewer studies investigated these applications. WS may alleviate these conditions predominantly through modulation of the hypothalamic-pituitary-adrenal and sympathetic-adrenal medullary axes, as well as through GABAergic and serotonergic pathways. While some studies link specific withanolide components to its neuropsychiatric benefits, there is evidence for the presence of additional yet unidentified active compounds in WS. Conclusion: While benefits were seen in the reviewed studies, significant variability in the WS extracts examined prevents a consensus on the optimum WS preparation or dosage from treating neuropsychiatric conditions. WS generally appears safe for human use; however, it will be important to investigate potential herb-drug interactions involving WS if used alongside pharmaceutical interventions. Further elucidation of active compounds of WS is also needed.

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Pharmacological and pharmacokinetic effect of a polyherbal combination with Withania somnifera (L.) Dunal for the management of anxiety

Cited by 6 publications

References 22 publications

Hyperglycemia-associated Alzheimer’s-like symptoms and other behavioral effects attenuated by Plumeria obtusa L. Extract in alloxan-induced diabetic rats

Hyperglycemia-associated Alzheimer’s-like symptoms and other behavioral effects attenuated by Plumeria obtusa L. Extract in alloxan-induced diabetic rats

Chronically administered Agave americana var. marginata extract ameliorates diabetes mellitus, associated behavioral comorbidities and biochemical parameters in alloxan-induced diabetic rats

Effects of Withania somnifera (Ashwagandha) on Stress and the Stress- Related Neuropsychiatric Disorders Anxiety, Depression, and Insomnia

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