Pharmacological and parametrical investigation of prepulse inhibition of startle and prepulse elicited reactions in Wistar rats

Brosda, Jan; Hayn, Linda; Klein, Charlotte; Koch, Michael; Meyer, Cora; Schallhorn, Rieka; Wegener, Nico

doi:10.1016/j.pbb.2011.03.017

Cited by 25 publications

(16 citation statements)

References 19 publications

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“…[44][45][46] While it is likely that there are partly independent pathways for PPI at short vs long ISI delays in mice, an exact definition of each respective pathway remains elusive. 45,47 In previous studies, we and others have observed differential effects of treatments depending on the ISI, 32,[48][49][50] similar to the effect of the hBDNF Val/Met genotype and chronic CORT treatment in this study. A mechanism for this effect, given a lack of defined circuitry, remains difficult to assess.…”

Section: Translational Merit and Model Validitysupporting

confidence: 87%

BDNF Val66Met Genotype Interacts With a History of Simulated Stress Exposure to Regulate Sensorimotor Gating and Startle Reactivity

Notaras

Hill

Gogos

et al. 2016

SCHBUL

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Reduced expression of Brain-Derived Neurotrophic Factor (BDNF) has been implicated in the pathophysiology of schizophrenia. The BDNF Val66Met polymorphism, which results in deficient activity-dependent secretion of BDNF, is associated with clinical features of schizophrenia. We investigated the effect of this polymorphism on Prepulse Inhibition (PPI), a translational model of sensorimotor gating which is disrupted in schizophrenia. We utilized humanized BDNF Val66Met (hBDNF Val66Met) mice which have been modified to carry the Val66Met polymorphism, as well as express humanized BDNF in vivo. We also studied the longterm effect of chronic corticosterone (CORT) exposure in these animals as a model of history of stress. PPI was assessed at 30 ms and 100 ms interstimulus intervals (ISI). Analysis of PPI at the commonly used 100 ms ISI identified that, irrespective of CORT treatment, the hBDNF

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Section: Translational Merit and Model Validitysupporting

confidence: 87%

BDNF Val66Met Genotype Interacts With a History of Simulated Stress Exposure to Regulate Sensorimotor Gating and Startle Reactivity

Notaras

Hill

Gogos

et al. 2016

SCHBUL

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“…The absence of differences between groups in PPI75 (5 db above background) could be related to the low intensity of the prepulse signal. In this way, it has been reported that prepulses of 4 or 8 db above background do not elicit motor responses per se (same values of motor activity than no stimulus) in adult male Wistar rats [36]. In accordance, in the present experiment the levels of startle inhibition are low (see Fig.…”

Section: Discussionsupporting

confidence: 91%

Finasteride administration potentiates the disruption of prepulse inhibition induced by forced swim stress

Pallarès

Llidó

Mòdol

et al. 2015

Behavioural Brain Research

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“…Interestingly, MK-801 attenuates social preferences in mice [20], reduces social investigative behaviors [21] and increases social withdrawal in rats [22]. It also causes hyperactivity in rats [21], circling behavior in mice [23], and reduction of prepulse inhibition in rats [24]. In mice, it creates auditory electrophysiology disruptions that are reminiscent of those found in autism [25].…”

Section: Introductionmentioning

confidence: 99%

Assessing Social Engagement in Heterogeneous Groups of Zebrafish: A New Paradigm for Autism-Like Behavioral Responses

Maaswinkel¹,

Zhu²,

Weng³

2013

PLoS ONE

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Because of its highly developed social character, zebrafish is a promising model system for the study of the genetic and neurochemical basis of altered social engagement such as is common in autism and schizophrenia. The traditional shoaling paradigm investigates social cohesion in homogeneous groups of zebrafish. However, the social dynamics of mixed groups is gaining interest from a therapeutic point of view and thus warrants animal modeling. Furthermore, mutant zebrafish are not always available in large numbers. Therefore, we developed a new paradigm that allows exploring shoaling in heterogeneous groups. The effects of MK-801, a non-competitive antagonist of the glutamate N-methyl-D-aspartate (NMDA) receptor, on social cohesion were studied to evaluate the paradigm. The drug has previously been shown to mimic aspects of autism and schizophrenia. Our results show that a single MK-801-treated zebrafish reduced social cohesion of the entire shoal drastically. Preliminary observations suggest that the social dynamics of the shoal as a whole was altered.

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Pharmacological and parametrical investigation of prepulse inhibition of startle and prepulse elicited reactions in Wistar rats

Cited by 25 publications

References 19 publications

BDNF Val66Met Genotype Interacts With a History of Simulated Stress Exposure to Regulate Sensorimotor Gating and Startle Reactivity

BDNF Val66Met Genotype Interacts With a History of Simulated Stress Exposure to Regulate Sensorimotor Gating and Startle Reactivity

Finasteride administration potentiates the disruption of prepulse inhibition induced by forced swim stress

Assessing Social Engagement in Heterogeneous Groups of Zebrafish: A New Paradigm for Autism-Like Behavioral Responses

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