Pharmacological and non-pharmacological countermeasures to Space Motion Sickness: a systematic review

Khalid, Akil; Prusty, Pragnya P.; Arshad, Iqra; Gustafson, Hannah E.; Jalaly, Isra; Nockels, Keith; Bentley, Barry L.; Goel, Rahul; Ferrè, Elisa R.

doi:10.3389/fncir.2023.1150233

Cited by 4 publications

(3 citation statements)

References 33 publications

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“…Passengers who were under stress before the trip reported feeling ill when travelling by minibus. In agreement with the hypothesis expressed in earlier studies [3,20,23,24], the findings analyzed the relationship between stress and passengers feeling ill. Nonetheless, previous investigations did not adequately explain the patterns and nature of stress which is recognized as determinant of travel.…”

Section: Findings In Relation To Socio-cultural Factors and Feeling U...supporting

confidence: 90%

Feeling unwell of passenger travel by small vehicles and associated risk factors in the North Shewa Zone, Oromiya, Ethiopia

Tadese,

Nesibu,

Sitotaw

2024

BMC Public Health

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The current study investigated how and why sociocultural structures, situational conditions, and personal behavioural factors cause passengers to feel ill when travelling by minibuses, drawing on ideas from the social construction theory of illness. A significant objective was to investigate associated risk variables that influence passengers’ feelings of illness related to the social environment, addressing their beliefs, meanings, practices, and behaviours. A survey method was used to obtain data from 384 passengers for the study. The results of logistic regression indicated that feeling ill when travelling by minibuses differed from passenger to passenger; then, they had their own set of practical and emotional challenges that had no known medical reason. Compared with male and older passengers, female and younger passengers were more likely to feel ill. Furthermore, stress and role-set effects increased passengers’ experiences of feeling ill more than did passengers who had no stress prior to the trip and who had only one role. Additionally, passengers who travelled intermittently, utilized suppression techniques to lessen travel discomfort, and fastened seat belts were less likely to experience symptoms of illness. Passengers who travelled on unsafe roads and used alcohol before travel, on the other hand, were more likely to feel ill than those who travelled on safer roads and did not use alcohol before the trip. The findings suggest that passengers should be aware of predisposing conditions that result in illness, be able to rest before travelling, and use all suppressive methods to reduce or prevent illness while travelling by small buses.

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Section: Findings In Relation To Socio-cultural Factors and Feeling U...supporting

confidence: 90%

Feeling unwell of passenger travel by small vehicles and associated risk factors in the North Shewa Zone, Oromiya, Ethiopia

Tadese,

Nesibu,

Sitotaw

2024

BMC Public Health

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“…Space motion sickness, which affects around 70% of astronauts, has symptoms of fatigue, vertigo, nausea, dizziness, headaches, vomiting, and cold sweating. It might cause potential problems for mission-critical tasks and astronauts' wellbeing (Khalid et al, 2023). Additionally, astronauts also exhibit immune system dysregulation during space flight (Baba et al, 2020).…”

Section: Potential Applications Of Safflower In Space Medicinementioning

confidence: 99%

Genetic diversity, clinical uses, and phytochemical and pharmacological properties of safflower (Carthamus tinctorius L.): an important medicinal plant

Cheng,

Yang,

et al. 2024

Front. Pharmacol.

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Safflower (Carthamus tinctorius L.), a member of the Asteraceae family, is widely used in traditional herbal medicine. This review summarized agronomic conditions, genetic diversity, clinical application, and phytochemicals and pharmacological properties of safflower. The genetic diversity of the plant is rich. Abundant in secondary metabolites like flavonoids, phenols, alkaloids, polysaccharides, fatty acids, polyacetylene, and other bioactive components, the medicinal plant is effective for treating cardiovascular diseases, neurodegenerative diseases, and respiratory diseases. Especially, Hydroxysafflor yellow A (HYSA) has a variety of pharmacological effects. In terms of treatment and prevention of some space sickness in space travel, safflower could be a potential therapeutic agent. Further studies are still required to support the development of safflower in medicine. Our review indicates that safflower is an important medicinal plant and research prospects regarding safflower are very broad and worthy of further investigation.

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“…Finally, it should also be considered that, with the exception of few studies (Senot et al, 2005;de la Malla and López-Moliner, 2015;La Scaleia et al, 2019)-which manipulated the law of motion of a ball projected toward the observer (i.e., visual looming stimuli)-studies validating the idea of the internal model of gravity have generally used visual motion projected tangentially to the observer. In this respect, acquiring deeper knowledge on how the brain combines gravity prior information with incoming sensory signals by using more immersive virtual reality settings, may also impact on the understanding of the adaptive processes to altered gravity environments and on the identification of potential countermeasures to the space motion sickness (Arshad and Ferré, 2023;Bizzarri et al, 2023;Khalid et al, 2023).…”

Section: Introductionmentioning

confidence: 99%

Interception of vertically approaching objects: temporal recruitment of the internal model of gravity and contribution of optical information

Delle Monache,

Paolocci,

Scalici

et al. 2023

Front. Physiol.

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Introduction: Recent views posit that precise control of the interceptive timing can be achieved by combining on-line processing of visual information with predictions based on prior experience. Indeed, for interception of free-falling objects under gravity’s effects, experimental evidence shows that time-to-contact predictions can be derived from an internal gravity representation in the vestibular cortex. However, whether the internal gravity model is fully engaged at the target motion outset or reinforced by visual motion processing at later stages of motion is not yet clear. Moreover, there is no conclusive evidence about the relative contribution of internalized gravity and optical information in determining the time-to-contact estimates.Methods: We sought to gain insight on this issue by asking 32 participants to intercept free falling objects approaching directly from above in virtual reality. Object motion had durations comprised between 800 and 1100 ms and it could be either congruent with gravity (1 g accelerated motion) or not (constant velocity or -1 g decelerated motion). We analyzed accuracy and precision of the interceptive responses, and fitted them to Bayesian regression models, which included predictors related to the recruitment of a priori gravity information at different times during the target motion, as well as based on available optical information.Results: Consistent with the use of internalized gravity information, interception accuracy and precision were significantly higher with 1 g motion. Moreover, Bayesian regression indicated that interceptive responses were predicted very closely by assuming engagement of the gravity prior 450 ms after the motion onset, and that adding a predictor related to on-line processing of optical information improved only slightly the model predictive power.Discussion: Thus, engagement of a priori gravity information depended critically on the processing of the first 450 ms of visual motion information, exerting a predominant influence on the interceptive timing, compared to continuously available optical information. Finally, these results may support a parallel processing scheme for the control of interceptive timing.

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Pharmacological and non-pharmacological countermeasures to Space Motion Sickness: a systematic review

Cited by 4 publications

References 33 publications

Feeling unwell of passenger travel by small vehicles and associated risk factors in the North Shewa Zone, Oromiya, Ethiopia

Feeling unwell of passenger travel by small vehicles and associated risk factors in the North Shewa Zone, Oromiya, Ethiopia

Genetic diversity, clinical uses, and phytochemical and pharmacological properties of safflower (Carthamus tinctorius L.): an important medicinal plant

Interception of vertically approaching objects: temporal recruitment of the internal model of gravity and contribution of optical information

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