Pharmacological and chemical properties of some marine echinoderms

Marmouzi, Ilias; Tamsouri, Naoufal; Hamdani, Maha El; Attar, Aisha El; Kharbach, Mourad; Alami, Rachid; Jemli, Meryem El; Cherrah, Yahia; Ebada, Sherif S.; Faouzi, My El Abbés

doi:10.1016/j.bjp.2018.05.015

Cited by 14 publications

(12 citation statements)

References 39 publications

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“…Ophiocoma dentata crude extract have shown antimicrobial activity against several bacterial stains including S. aureus , V. damsela and P. aeruginosa , E. coli , and S. faecalis unlike the pure compounds when exhibited antimicrobial activities against P. aeruginosa alone. Ophiura albida have also been reported to possess antimicrobial activities as well as α-glucosidase activity that is involved in glucose and starch digestion 38 . Red sea marine organisms have also reported for antimicrobial activity.…”

Section: Discussionmentioning

confidence: 99%

Cytotoxic and antimicrobial activities of two new sesquiterpenoids from red sea brittle star Ophiocoma dentata

Feky

Hafez

Moneim

et al. 2022

Sci Rep

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Bioactive compounds were extracted from a locally available brittle star; Ophiocoma dentata, collected from the Red Sea, Egypt. Two new sesquiterpenoids; 8, 11-epoxy-9(15)-himachaladiene-4-ol (O8-ophiocomane) and, 11-epoxy-9(15)-himachaladiene-4-ol (O7-ophiocomane) were isolated and characterized using appropriate techniques. Structure elucidation was estimated via 1D NMR, 2D NMR, FT-IR and mass spectroscopy analyses. The isolated compounds were tested for cytotoxic, antibacterial and antifungal activities. Pure compounds showed a dose dependent reduction in MCF-7 cells viability with LC50 of 103.5 and 59.5 μg/ml for compounds 1 and 2 respectively compared to the chemotherapeutic drug cisplatin (47.4 µg/ml). In vivo experiments showed that O. dentate extract significantly reduced tumor progression and improved hematological parameters and liver functions of tumor-bearing mice when administered either before or after tumor cells’ injection. The most remarkable antimicrobial effects of O. dentate crude extract were against Staphylococcus aureus, Vibrio damsela and Pseudomonasaeruginosa while the pure compounds showed activity against P. aeruginosa alone. Neither the crude extract nor the pure compounds have shown activity against Aeromonas hydrophila. These results indicates that O. dentata extract and newly isolated compounds have shown a promising cytotoxic, antiproliferative and antimicrobial activities that might be useful for pharmaceutical applications.

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Section: Discussionmentioning

confidence: 99%

Cytotoxic and antimicrobial activities of two new sesquiterpenoids from red sea brittle star Ophiocoma dentata

Feky

Hafez

Moneim

et al. 2022

Sci Rep

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“…Black seed oil containing 1‐(+)‐ascorbic acid 2,6‐dihexadecanoate as the major phytoconstituent was found to show antimicrobial properties against different bacterial and fungal strains (Ashraf et al, 2017). 1‐heptatriacotanol extracted from some marine echinoderms exhibited antimicrobial activity against human pathogens such as Staphylococcus aureus , Escherichia coli , Pseudomonas aeruginosa , Salmonella enterica and Bacillus subtilis (Marmouzi et al, 2018). Hexadecanoic acid extracted from Red Seaweed Gracilaria arcuata showed antimicrobial properties against Aeromonas hydrophila in the bioautography assay (Wijnana et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

Mitigating Aeromonas hydrophila infection in Nile tilapia through dietary Basella alba and Withania somnifera supplementation: A bioassay‐guided fractionation approach

Mukherjee

Ghosal

Marik

et al. 2022

Aquaculture Research

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The present study aimed to identify the antibacterial bioactive compounds in Withania roots and Basella leaves against Aeromonas infection in Nile tilapia. Withania ethanol extract (EW, ZoI 10.72 ± 1.028 mm) and Basella methanol extract (MB, ZoI 10.83 ± 1.058 mm) showed the highest antibacterial activity in disc diffusion assay.In in vivo experiment, Nile tilapia (25.61 ± 0.31 g) were fed basal, EW and MB (both at 0.7 g/kg feed) diets for 15 days either before being intraperitoneally injected with Aeromonas and basal diet feeding for 7 days (prophylactic) or after bacterial injection and basal diet feeding for 7 days (therapeutic). Fish fed EW and MB fortified diets showed significantly (p < 0.05) lower mortality, alkaline phosphatase, glutamic oxaloacetic transaminase, glutamic pyruvate transaminase activities, HSP70, Caspase3, IFN-ɣ, IL-1 β, TNFα level, while significantly (p < 0.05) higher weight gain, protein efficiency ratio, respiratory burst, lysozyme, phagocytotic activity, plasma total protein, total immunoglobulin content, RBC, WBC count, haemoglobin, haematocrit, mean corpuscular haemoglobin concentration, mean corpuscular volume, lymphocytes, neutrophils, monocytes percentages and superoxide dismutase, catalase, glutathione peroxidase activities compared to basal diet-fed fish. EW showed significantly (p < 0.05) better antibacterial efficacy compared to MB. Prophylactic treatment showed better results compared to therapeutic treatment. Bioassay-guided chromatography and GC-MS analysis revealed the presence of hexadecanoic acid, phytol, cis, cis, cis-7,10,13-hexadecatrienal in EW and α-tocopherol, 1-(+)-ascorbic acid 2,6-dihexadecanoate, 1-heptatriacotanol in MB, which was reported to have antibacterial, antioxidative and immunostimulatory potential. Present results indicate prospective use of EW as a prophylactic immunostimulant and effective therapeutic remedy against Aeromonas in Nile tilapia.

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“…In traditional medicine, echinoderms such as Oreaster reticulate, Echinaster echinophorus, Luidia senegalensis, Mellita quinquiesperforata, Echinometra lucunter and Echinaster brasiliensis are used in Brazil against asthma, alcoholism, bronchitis, diabetes and heart disease. This therapeutic potential is due to the ethnopharmacological information of natural products (Marmouzi, et al, 2017). The route of administration reported is oral, by preparing an infusion or direct addition to powdered roasted echinoderm foods.…”

Section: Discussionmentioning

confidence: 99%

“…In O. nigra, the anticoagulant activity of acid mucopolysaccharides in the mucous secretions has been demonstrated, in addition to the glycoproteins present in the secretion and the cell surface it has been reported to inhibit the adhesion of human neutrophils to endothelial cells, proposing a mechanism of Competitive inhibition of this interaction Oreaster reticulate, Echinaster echinophorus, Luidia senegalensis, Mellita quinquiesperforata, Echinometra lucunter and Echinaster brasiliensis are used in Brazil against asthma, alcoholism, bronchitis, diabetes and heart disease. This therapeutic potential is due to the ethnopharmacological information of natural products (Marmouzi, et al, 2017). The route of administration reported is oral, by preparing an infusion or direct addition to powdered roasted echinoderm foods.…”

Section: Discussionmentioning

confidence: 99%

Antiparasitic activity of Ophiocomina nigra in Entamoeba invadens

Sánchez-Ramos

Valdés-Santiago

Domínguez

et al. 2019

EJPG

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Objetive: Analyze the antiparasitic activity of marine invertebrate Ophiocomina nigra in Entamoeba invadens. Methodology. In O. nigra, an analysis of the quantitative proximal chemical composition (moisture, ash, protein, lipids and nitrogen-free extract) was performed. In addition, the determination of the total protein pattern (SDS-PAGE 10%). On the other hand, the antiparasitic activity of E. invadens trophozoites was determined, which were grown in TYI medium at 28 ° C and exposed to the aqueous extract of O. nigra for 24 hours. Subsequently, metabolic activity (XTT assay) was determined and morphology was analyzed. Cytotoxicity tests were performed on human liver cells (Hep G2) exposed for 24 hours to O. nigra (XTT test) and the biomass was determined (violet crystal staining). Contribution. The antiparasitic activity of O. nigra in E. invadens and the cytotoxic effect in human liver cells was determined. There are few scientific studies of this marine invertebrate on its use in traditional medicine, so it is important to analyze its effects and therapeutic value.

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Pharmacological and chemical properties of some marine echinoderms

Cited by 14 publications

References 39 publications

Cytotoxic and antimicrobial activities of two new sesquiterpenoids from red sea brittle star Ophiocoma dentata

Cytotoxic and antimicrobial activities of two new sesquiterpenoids from red sea brittle star Ophiocoma dentata

Mitigating Aeromonas hydrophila infection in Nile tilapia through dietary Basella alba and Withania somnifera supplementation: A bioassay‐guided fractionation approach

Antiparasitic activity of Ophiocomina nigra in Entamoeba invadens

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