Pharmacological Analysis of Two Ethanolic Extracts From Species of Fridericia Genus

Abstract

ABSTRACT:The present study aimed to evaluate the biological activity of the species Fridericia platyphylla e Fridericia florida, through pharmacological tests. The doses of FpEE and FfEE (20 and 100 mg/kg) were used to assess anti-inflammatory activity (carrageenan-induced mice paw edema and formalin test) and analgesic activity (acetic acid-induced writhing and hot plate) by both extracts. In the carrageenan-induced paw edema the highest activity was observed by the FfEE at dose of 20 mg/kg in the third hour (26.63%), followed by FpEE (23.42%) at same dose in the first hour. In the acetic acid-induced writhing, the highest activity was observed by both doses of FpEE, while in hot plate test, FfEE has more pronounced activity than FpEE in times 60 and 90 minutes by both doses. In formalin test, only FfEE was significant at neurogenic pain phase inhibiting the licking time by 29.58%, whereas, FpEE has the highest activity at inflammatory pain phase (84.67%). This study showed that ethanolic extract of F. platyphylla and F. florida plants induced anti-inflammatory and analgesic effect in different tests carried out with Swiss mice albine.