Pharmacological analysis of receptors for bombesin-related peptides on guinea pig gallbladder smooth muscle

Bombesin receptor regulation of emotional memory

“…The NMBR is coupled to the G q protein (G q ) and the phospholipase C (PLC)/protein kinase C (PKC) signaling pathway, and its activation leads also to stimulation of phospholipases A 2 and D and extracellular signal-regulated protein kinase (ERK)/mitogen-activated protein kinase (MAPK; Corjay et al, 1991;Wada et al, 1991;Moody et al, 1992Moody et al, , 1995Wang et al, 1992;Dobrzanski et al, 1993;Benya et al, 1995;. The physiological functions regulated by the NMBR in peripheral tissues include the contraction of gastrointestinal and urogenital smooth muscles and pituitary gland secretion (Severi et al, 1991;Rettori et al, 1992;Kilgore et al, 1993;Parkman et al, 1994;Milusheva et al, 1998).…”

International Union of Pharmacology. LXVIII. Mammalian Bombesin Receptors: Nomenclature, Distribution, Pharmacology, Signaling, and Functions in Normal and Disease States

“…Studies comparing the potencies of NMB to GRP as well as binding studies or antagonist studies provide evidence that the BB 1 receptor can stimulate contraction of urogenital and gastrointestinal smooth muscle (esophageal, gastric, colon, and gallbladder) (Regoli et al, 1988;von Schrenck et al, 1989von Schrenck et al, , 1990Severi et al, 1991;Kilgore et al, 1993;Parkman et al, 1994;Milusheva et al, 1998), potently inhibit thyrotropin release from the pituitary gland by acting as an autocrine and paracrine regulator (Rettori et al, 1992;Pazos-Moura et al, 1996;Ortiga-Carvalho et al, 2003), and have potent CNS effects including inhibiting food intake independent of BB 2 stimulation (Ladenheim et al, 1994(Ladenheim et al, , 1996b(Ladenheim et al, , 1997bMerali et al, 1999;Ladenheim and Knipp, 2007) and mediating aspects of the stress and fear responses as well as various behaviors such as spontaneous activity (Merali et al, 2002(Merali et al, , 2006. BB 1 receptor knockout mice are now available and have undergone a limited number of investigations for actions of NMB Oeffner et al, 2000;Yamada et al, 2002bYamada et al, , 2003Yamano et al, 2002) (Table 1).…”

Enhanced Bradykinin-Stimulated Prostaglandin Release in the Acutely Inflamed Guinea Pig Gallbladder Is Due to New Synthesis of Cyclooxygenase 1 and Prostacyclin Synthase

“…The guinea pig is a known excellent model for examining gallbladder contractility and thus has the potential to be an ideal model for determining the role of eicosanoids in altered gallbladder contractility during evolving inflammation. Thus, this study was designed to test re- producibility of the common bile duct ligation model in the guinea pig which is better suited for studying gallbladder contractility, an aim of current and future studies [23].…”