Pharmacological alteration of hyper-reactivity in rats with septal and hypothalamic lesions

Beattie, Craig W.; Chernov, H. I.; Bernard, Patrick S.; Glenny, Fred H.

doi:10.1016/0028-3908(69)90023-9

Cited by 11 publications

(2 citation statements)

References 16 publications

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“…This obviously corresponds to the present findings in the 6-0H-DA lesioned rats. Gladfelter and Brobeck (1962) found a permanent decrease in spontaneous locomotor activity after lateral hypothalamic lesions and Beattie et al (1969) mentioned a condition approaching catalepsia which could not be reversed by strong tactile stimulation. Balagura et al (1969) described both the state of catalepsia and the state of hypoactivity but found no correlation between catalepsia and deficiency in food and water intake, while hypoactivity in an open field situation decreased after all lateral hypothalamic lesions.…”

Section: Discussionmentioning

confidence: 99%

Adipsia and Aphagia after 6‐Hydroxydopamine Induced Degeneration of the Nigro‐striatal Dopamine System

Ungerstedt

1971

Acta Physiologica Scandinavica

1,220

344

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The functional role of the nigro-striatal dopamine (DA) system has been investigated on the basis of a .recent detailed mapping of its path and a new method of lesioning the catecholamine systems selectively by intracerebral injection of 6-hydroxydopamine (6-0H-DA). The investigation was especially focused on the symptoms of adipsia, aphagia, hypokinesia and catalepsia after lateral hypothalamic lesions as such lesions may interrupt the ascending DA axons. Electrocoagulations or 6-0H-DA lesions were performed bilaterally at several sites along the DA pathway and the behavioural effects were evaluated in relation to the histochemically detected lesion of the DA pathway. It was concluded that bilateral complete degeneration of the nigro-striatal DA pathway produces severe, long lasting adipsia and aphagia, hypoactivity, difficulties to initiate activity and loss of exploratory behaviour and curiosity. Experiments with DA receptor stimulating and blocking drugs supported the lesion results. Catalepsia and som~olence were attributed to the interruption of other pathways. The results suggest an important role for the nigro-striatal DA system and the striatum in the control of behaviour. A number of symptoms earlier related to the hypothalamus may in fact be due to disturbance of the nigro-striatal DA system.

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Section: Discussionmentioning

confidence: 99%

Adipsia and Aphagia after 6‐Hydroxydopamine Induced Degeneration of the Nigro‐striatal Dopamine System

Ungerstedt

1971

Acta Physiologica Scandinavica

1,220

344

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“…In rodents, benzodiazepines have consistently been found to attenuate defensive reactions induced by a variety of techniques, including conspecific attack (Chance and Silverman 1964;Poole 1973;Miczek 1974;Krsiak 1975;Krsiak et al 1981Krsiak et al , 1984Yoshimura and Ogawa 1984), the presence of a predator (Cameron and Blampied 1980), septal lesions (Schallek et al 1962;Horovitz et al 1963;Stark and Henderson 1966;Beattie et al 1969;Sofia 1969;Goldberg 1970), anterior hypothalamic lesions (Blyther and Marriott 1969), hypothalamic stimulation (Panksepp 1971;Murasaki et al 1976), dorsal PAG stimulation (Graeff et al 1986), apomorphine treatment (Senault 1970) and footshock (Hoffmeister and Wuttke 1969;Sofia 1969;Tedeschi et al 1969;Christmas and Maxwell 1970;Irwin et al 1971 ;Manning and Elsmore 1972;Quenzer et al 1974;Robichaud and Goldberg 1974). Furthermore, and almost by definition, benzodiazepines attenuate aspects of defense elicited by stimuli employed in animal models of anxiety (see Treit 1985 for recent review).…”

mentioning

confidence: 98%

Attenuation of defensive threat and attack in wild rats (Rattus rattus) by benzodiazepines

Hori

Rodgers

et al. 1989

Psychopharmacology

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A battery of tests designed to elicit reactions to a variety of non-painful threat stimuli was used to study the effects of chlordiazepoxide (5-20 mg/kg), diazepam (1-5 mg/kg) and midazolam (1-10 mg/kg) on the defensive repertoire of wild Rattus rattus. The most consistent effect of benzodiazepine treatment, across compounds and tests, was a marked reduction in defensive threat and attack behaviors, with midazolam effective over a wider range of situations. In contrast, effects on freezing and flight reactions were more variable, differing substantially as a function of stimulus context. The general profile of observed changes in defense cannot be explained in terms of either non-specific behavioral suppression or a global reduction in defensiveness. Rather, our findings suggest that benzodiazepines may primarily induce a shift within the defense repertoire.

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General Pharmacology and Neuropharmacology of Benzodiazepine Derivatives

Haefely¹,

Pieri²,

Polc³

et al. 1981

Handbook of Experimental Pharmacology

114

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Pharmacological alteration of hyper-reactivity in rats with septal and hypothalamic lesions

Cited by 11 publications

References 16 publications

Adipsia and Aphagia after 6‐Hydroxydopamine Induced Degeneration of the Nigro‐striatal Dopamine System

Adipsia and Aphagia after 6‐Hydroxydopamine Induced Degeneration of the Nigro‐striatal Dopamine System

Attenuation of defensive threat and attack in wild rats (Rattus rattus) by benzodiazepines

General Pharmacology and Neuropharmacology of Benzodiazepine Derivatives

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