Pharmacological activity of the essential oil of Bupleurum gibraltaricum: Anti-inflammatory activity and effects on isolated rat uteri

Ocete, M. A.; Risco, S.; Zarzuelo, Antonio; Jiménez, J.

doi:10.1016/0378-8741(89)90036-6

Cited by 63 publications

(45 citation statements)

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“…Monoterpenes, the major components of essential oils, belong to the group of isoprenoids containing 10 C-atoms, and as essential oils and monoterpenes have a pleasant odor and taste when used at a low concentration, they have been extracted since ancient times from many plants, both edible and inedible, and are used today as food additives. 3-Carene has several biological effects such as antiinflammatory activity (Ocete et al, 1989), antibacterial activity (Pichette et al, 2006), antifungal activity (Cavaleiro et al, 2006) and inhibitory activity for acetylcholinesterase (Miyazawa and Yamafuji, 2005).…”

Section: Discussionmentioning

confidence: 99%

Low concentration of 3‐carene stimulates the differentiation of mouse osteoblastic MC3T3‐E1 subclone 4 cells

Jeong

Kim

Min

et al. 2007

Phytotherapy Research

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Recently, natural products have gained more interest as alternative treatments for metabolic bone disorders and for the maintenance of bone health. In this study, the anabolic activities of 89 natural compounds were evaluated by measuring the amount of newly synthesized calcium in the differentiation process of mouse osteoblastic MC3T3-E1 subclone 4 cells. Of these compounds, a low concentration (up to 5 μ μ μ μ μM) of 3-carene, which is a bicyclic monoterpene in essential oils extracted from pine trees, was shown to stimulate significantly the activity and expression of alkaline phosphatase, an early phase marker of osteoblastic differentiation, on differentiation day 9. On day 15, it dramatically promoted the induction of calcium in a dose-dependent manner. The stimulatory effect of 3-carene on mineralization might be associated with its potential to induce the protein expression/activation of the mitogen-activated protein kinases and the transcript levels of osteoblast mineralization-related genes such as osteopontin and type I collagen. Further studies are needed to determine the precise mechanism, but the anabolic activity of 3-carene in bone metabolism suggested that the use of natural additives to the diet including essential oils could have a beneficial effect on bone health.

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Section: Discussionmentioning

confidence: 99%

Low concentration of 3‐carene stimulates the differentiation of mouse osteoblastic MC3T3‐E1 subclone 4 cells

Jeong

Kim

Min

et al. 2007

Phytotherapy Research

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“…For instance, the anti-inflammatory activity of intraperitoneally and orally administered essential oils of B. gibraltaricum and B. fruticosum and their major components were evaluated against both acute inflammation using carrageenan-induced oedema model and chronic proliferative inflammation by evaluating the granuloma formation. [16,18] The two oils showed a dose-dependent activity in both systems but the effect was more obvious in the acute test and by the intraperitoneal route. In addition, B. gibraltaricum oil was more active than B. fruticosum oil and exhibited about one-third of the activity shown by indometacin in the paw oedema model.…”

Section: B Rigidummentioning

confidence: 99%

“…This difference can be used to distinguish between oils from Italy or Spain and those from China. [16][17][18][19] …”

Section: Secondary Metabolites Present In Essential Oilsmentioning

confidence: 99%

“…(+) PGE2 production [84,92] Saikosaponin B2 (+) PGE2 production [73,84,92] (-) Human coronavirus (HCoV) replication Saikogenin D (-) PGE2 production [95] B. fruticescens Butanol extract (-) Acute inflammation [96] Methanol extract (-) 5-LOX, COX-1 [97] Essential oil (-) Acute inflammation [17] Fruticesaponin B (-) Acute inflammation [96] B. fruticosum Petroleum ether extract (-) IL-1b, IL-6, TNF-a, PGE2 [98] Essential oil (-) Acute and chronic inflammation [18,99] Oxytocin antagonism Antifungal Saikosaponin fraction Hepatoprotective against DMN [100] Morinin L (-) IL-1, IL-6, IL-8, TNF-a, NF-kB [101] Buddlejasaponin IV Hepatoprotective against DMN [100] B. gibraltaricum Methanol extract (-) Acute inflammation [102] Essential oil (-) Acute and chronic inflammation [16,19] Oxytocin antagonism Antibacterial, antifungal Saikosaponin I (-) Acute inflammation [102] B. kaoi Saponin-rich fraction Hepatoprotective against CCL4 [103][104][105][106] (-) sGOT, sGPT, AST and ALT levels (+) IFN-g level Cytotoxic against A549 cell line Water extract (+) IFN-g and GSH levels [66,105] (-) Coxsackie B1 replication Polysaccharide-rich fraction (-) sGOT and sGPT levels [105] (+) IFN-g and GSH levels…”

Section: Anti-inflammatory Activitymentioning

confidence: 99%

“…[16,18] Saikosaponin A inhibited the passive cutaneous anaphylaxis reaction in rats and suppressed asthmatic bronchoconstriction in sensitized guinea-pigs at a dose of 1 mg/kg. In addition, weak inhibitory activity on histamine-induced tracheal contraction in guineapigs and on histamine release induced by A-23187 in rat mast cells were observed.…”

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Genus Bupleurum: a review of its phytochemistry, pharmacology and modes of action

Ashour

Wink

2010

Journal of Pharmacy and Pharmacology

225

161

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Objectives Radix Bupleuri represents one of the most successful and widely used herbal drugs in Asia for treatment of many diseases over the past 2000 years. Thorough studies have been carried out on many species of this genus and have generated immense data about the chemical composition and corresponding biological activity of extracts and isolated secondary metabolites. In this work, we review the chemistry and pharmacology of the genus Bupleurum and explore the relationships between the pharmacological effects and the chemical composition of these drugs. Key findings Early studies on the genus Bupleurum had focused only on the traditional uses of the plants in the treatment of inflammatory disorders and infectious diseases. After chemical profiling, several groups of secondary metabolites were characterized with relevant biological activity: triterpene saponins (saikosaponins), lignans, essential oils and polysaccharides. As a result, present interest is now focused on the bioactivity of the isolated triterpene saponins acting as immunomodulatory, anti-inflammatory and antiviral agents, as well as on the observed ant-iulcer activity of the polysaccharides and anti-proliferative activity of different lignans. Many saikosaponins exhibited very potent anti-inflammatory, hepatoprotective and immunomodulatory activities both in vivo and in vitro. Conclusions Further investigations and screenings are required to explore other Bupleurum species, to evaluate the clinical safety and possible interactions with other drugs or herbs. Standardization of Bupleuri extracts is crucial for them being integrated into conventional medicine due to large chemical and biological variations between different species and varieties.

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First Enantioselective Synthesis and Absolute Stereochemistry Assignment of New Monoterpene Aldehyde‐Esters from Bupleurum gibraltaricum

et al. 2007

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The first enantioselective synthesis of two new monoterpene aldehyde‐esters from Bupleurum gibraltaricum, starting from an enantiopure building block, is described. The key step is a strictly controlled esterification to afford the somewhat unstable target compounds. The previously unknown absolute stereochemistries of these natural products have been established.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)

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Pharmacological activity of the essential oil of Bupleurum gibraltaricum: Anti-inflammatory activity and effects on isolated rat uteri

Cited by 63 publications

References 4 publications

Low concentration of 3‐carene stimulates the differentiation of mouse osteoblastic MC3T3‐E1 subclone 4 cells

Low concentration of 3‐carene stimulates the differentiation of mouse osteoblastic MC3T3‐E1 subclone 4 cells

Genus Bupleurum: a review of its phytochemistry, pharmacology and modes of action

First Enantioselective Synthesis and Absolute Stereochemistry Assignment of New Monoterpene Aldehyde‐Esters from Bupleurum gibraltaricum

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