Pharmacological Activities of Soursop (Annona muricata Lin.)

Hypertension is one of the risk factors for cardiovascular disease that has become a serious global health problem. In terms of searching for active compounds that have the potential as antihypertensives, phytochemical studies on natural ingredients are continuously being carried out. One of them is soursop which is known to be able to lower blood pressure in people with hypertension. Alkaloids contained in soursop leaves can work as Angiotensin Converting Enzyme Inhibitor hat reduce ADH hormone secretion. This research was conducted to find out the antihypertensive potential of natural compounds in soursop leaves that interact with ACEI. The research was carried out in two steps, namely molecular anchoring and pharmacophore modeling. Based on the research that has been done, Anomuricine is the compound with the most potential interaction with ACEI with a Gibbs free energy of -9.13 kcal/mol and an inhibition constant of 202.83 uM. In addition, the Anomuricine compound has a lower binding energy than the standard ligand binding energy. Thus, it can be said that Anomuricine from soursop leaves (Annona muricata) has the potential as a lead compound.

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“…Therefore, Anomuricine has the most potential as a lead compound. This compound was long found and isolated in 1980 th by Leboeuf et al (19,20).…”

Section: Discussionmentioning

confidence: 95%

In Silico Study of Compound Extract In Soursop Plant (Annona muricata) as Ace Inhibitor In Hypertension Disease

Suhandi

Bagaskhara²,

Muchtaridi³

et al. 2022

IJCB

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“…The leaf extract of S. purpurea obtained using methanol also possesses antimycobacterial activity for the treatment of tuberculosis-like symptoms [3]. Given that many kinds of natural extracts from plants have antimicrobial activities [4][5][6][7][8], it is worth determining the antibacterial properties of S. purpurea. Prior to this study, whether (C) Stem and root.…”

Section: Introductionmentioning

confidence: 99%

Anticancer and Antioxidant Activities of the Root Extract of the Carnivorous Pitcher Plant Sarracenia purpurea

Huang

Chiang

Chen

et al. 2022

Plants

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The carnivorous pitcher plant Sarracenia purpurea exhibits many ethnobotanical uses, including the treatments of type 2 diabetes and tuberculosis-like symptoms. In this study, we prepared different extracts from the leaves (pitchers), stems, and roots of S. purpurea and investigated their antioxidant and anticancer properties. To evaluate the extraction efficiency, we individually used different solvents, namely methanol, ethanol, acetone, and distilled water, for S. purpurea extract preparations. The root extract of S. purpurea, obtained by 100% acetone (S. purpurea-root-acetone), had the highest anticancer activities, antioxidation capacity (the DPPH activity with IC50 of 89.3 ± 2.2 μg/mL), antibacterial activities, total phenolic content (33.4 ± 0.7 mg GAE/g), and total flavonoid content (107.9 ± 2.2 mg QUE/g). The most abundant compounds in S. purpurea-root-acetone were identified using gas chromatography–mass spectrometry; 7,8-Dihydro-α-ionone was the major compound present in S. purpurea-root-acetone. In addition, the co-cytotoxicity of S. purpurea-root-acetone (combined with the clinical anticancer drug 5-fluorouracil (5-FU) on the survival, apoptosis, proliferation, and migration of the 4T1 mammary carcinoma) was examined. The combination of 5-FU with S. purpurea-root-acetone could be highly efficient for anti-4T1 cells. We also found that S. purpurea-root-acetone could inhibit the enzymatic activity of human dihydroorotase (huDHOase), an attractive target for potential anticancer chemotherapy. The sic most abundant compounds in S. purpurea-root-acetone were tested using an in silico analysis via MOE-Dock software for their binding affinities. The top-ranked docking conformations were observed for 7,8-dihydro-α-ionone and stigmast-5-en-3-ol, suggesting the inhibition potential against huDHOase. Overall, the collective data in this study may indicate the pharmacological potentials of S. purpurea-root-acetone for possible medical applications.

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“…The fruits are mainly consumed fresh and the pulp can be used to develop several products such as ice-cream, juice, nectar, jelly, yogurt, among others [ 2 ]. Furthermore, in the last years there has been an increase in the interest of this crop due to its medicinal properties such as anthelmintic, antihypertensive, anti-inflammatory, antidiarrhea, antiparasitic, antimalarial, anticancer activities, among others [ 5 ]. Soursop is a climacteric fruit with a high respiration rate and ethylene production causing a fast fruit softening, leading to postharvest decay [ 6 , 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

Transcriptome Analysis of Soursop (Annona muricata L.) Fruit under Postharvest Storage Identifies Genes Families Involved in Ripening

Palomino-Hermosillo

Berúmen-Varela

Ochoa-Jiménez

et al. 2022

Plants

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Soursop (Annona muricata L.) is climacteric fruit with a short ripening period and postharvest shelf life, leading to a rapid softening. In this study, transcriptome analysis of soursop fruits was performed to identify key gene families involved in ripening under postharvest storage conditions (Day 0, Day 3 stored at 28 ± 2 °C, Day 6 at 28 ± 2 °C, Day 3 at 15 ± 2 °C, Day 6 at 15 ± 2 °C, Day 9 at 15 ± 2 °C). The transcriptome analysis showed 224,074 transcripts assembled clustering into 95, 832 unigenes, of which 21, 494 had ORF. RNA-seq analysis showed the highest number of differentially expressed genes on Day 9 at 15 ± 2 °C with 9291 genes (4772 up-regulated and 4519 down-regulated), recording the highest logarithmic fold change in pectin-related genes. Enrichment analysis presented significantly represented GO terms and KEGG pathways associated with molecular function, metabolic process, catalytic activity, biological process terms, as well as biosynthesis of secondary metabolites, plant hormone signal, starch, and sucrose metabolism, plant–pathogen interaction, plant–hormone signal transduction, and MAPK-signaling pathways, among others. Network analysis revealed that pectinesterase genes directly regulate the loss of firmness in fruits stored at 15 ± 2 °C.

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Pharmacological Activities of Soursop (Annona muricata Lin.)

Cited by 59 publications

References 92 publications

In Silico Study of Compound Extract In Soursop Plant (Annona muricata) as Ace Inhibitor In Hypertension Disease

In Silico Study of Compound Extract In Soursop Plant (Annona muricata) as Ace Inhibitor In Hypertension Disease

Anticancer and Antioxidant Activities of the Root Extract of the Carnivorous Pitcher Plant Sarracenia purpurea

Transcriptome Analysis of Soursop (Annona muricata L.) Fruit under Postharvest Storage Identifies Genes Families Involved in Ripening

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