Pharmacological Activities and Pharmacokinetics of Glycycoumarin

Tang, Yumei; Ou, Shuiping; Ye, Linhu; Wang, Sen

doi:10.1007/s43450-022-00342-x

Cited by 4 publications

(2 citation statements)

References 90 publications

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“…A combined analysis of differential metabolites and differential bacteria revealed a positive correlation between the abundance of Akkermansia muciniphila and glycycoumarin. Glycycoumarin, a representative coumarin compound, exhibits significant pharmacological activities, including antitumor, hepatoprotective, antispasmodic, antibacterial, and antiviral effects ( Tang et al., 2023 ). We also found a negative correlation between the abundance of Akkermansia muciniphila and the molecular substances named Ala-Lys-Asn-Glu.…”

Section: Discussionmentioning

confidence: 99%

Gut microbiota and metabolite variations in a migraine mouse model

Wang,

Liu,

Shi

et al. 2024

Front. Cell. Infect. Microbiol.

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Migraine is a prevalent clinical disorder characterized by recurrent unilateral throbbing headache episodes accompanied by symptoms such as nausea, vomiting, photophobia, and phonophobia. Despite its common occurrence, the diagnosis, pathophysiology, and treatment of migraine remain controversial. Extensive research has implicated the gut microbiota in various central nervous system disorders, including anxiety disorders, depression, and Parkinson’s disease. Some studies have also suggested that migraine may stem from disruptions to neurohormones and metabolism. This study aimed to investigate the disparities in gut microbiota and metabolites between migraine mice model and normal mice to shed light on the underlying mechanisms and potential therapeutic approaches. Distinct differences in gut microbial composition were observed between the migraine mouse model and normal mouse, indicating a potential correlation between these variations and the pathogenesis of migraine. This study provides evidence of differences in gut microbiota composition and metabolites between a migraine mouse model and normal mice, which showed that Akkermansiaceae constituted the most abundant taxon in the sham injection mouse group, while Lachnospiraceae constituted the most prevalent group in the migraine mouse model group. The associations between the abundances of Akkermansia muciniphila and Lachnospiraceae bacteria and metabolites suggested their potential roles in the pathogenesis of migraine. The altered abundance of Lachnospiraceae observed in migraine-afflicted mice and its correlations with changes in metabolites suggest that it may affect the host’s health. Thus, probiotic therapy emerges as a possible treatment for migraine. Moreover, significant disparities in gut metabolites were observed between the migraine mouse model and normal mice. These alterations encompass multiple metabolic pathways, suggesting that metabolic disturbances may also contribute to the development of migraines.

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Section: Discussionmentioning

confidence: 99%

Gut microbiota and metabolite variations in a migraine mouse model

Wang,

Liu,

Shi

et al. 2024

Front. Cell. Infect. Microbiol.

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“…In recent years, Yan Zhang and Jing Wang reported that ellipticine can alleviate glucocorticoid‐induced osteoporosis in vivo by increasing osteocalcin levels and increasing bone parameters, such as bone mineral content (BMC) and bone mineral density (BMD). It also lowers the levels of bone glycoprotein (BGP), acid phosphatase (ACP), alkaline phosphatase (ALP), tartrate‐resistant acid phosphatase (TRAP), and β‐CTx [31] …”

Section: Ellipticinementioning

confidence: 99%

Bioactivities and Action Mechanisms of Ellipticine Derivatives Reported Prior to 2023

Hou,

Xu,

Huang

et al. 2024

Chemistry & Biodiversity

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Currently, natural products are one of the priceless options for finding novel chemical pharmaceutical entities. Ellipticine is a naturally occurring alkaloid isolated from the leaves of Ochrosia elliptica Labill. Ellipticine and its derivatives are characterized by multiple biological activities. The purpose of this review was to provide a critical and systematic assessment of ellipticine and its derivatives as bioactive molecules over the last 60 years. Publications focused mainly on the total synthesis of alkaloids of this type without any evaluation of bioactivityhave been excluded. We have reviewed papers dealing with the synthesis, bioactivity evaluation and mechanism of action of ellipticine and its derivatives. It was found that ellipticine and its derivatives showed cytotoxicity, antimicrobial ability, and anti‐inflammatory activity, among which cytotoxicity toward cancer cell lines was the most investigated aspect. The inhibition of DNA topoisomerase II was the most relevant mechanism for cytotoxicity. The PI3K/AKT pathway, p53 pathway, and MAPK pathway were also closely related to the antiproliferative ability of these compounds. In addition, the structure‐activity relationship was deduced, and future prospects were outlined. We are confident that these findings will lay a scientific foundation for ellipticine‐based drug development, especially for anticancer agents.

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A breakthrough in periodontitis treatment: Revealing the pharmacodynamic substances and mechanisms of Kouqiangjie formula

Wu,

Liu,

et al. 2024

Journal of Ethnopharmacology

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Pharmacological Activities and Pharmacokinetics of Glycycoumarin

Cited by 4 publications

References 90 publications

Gut microbiota and metabolite variations in a migraine mouse model

Gut microbiota and metabolite variations in a migraine mouse model

Bioactivities and Action Mechanisms of Ellipticine Derivatives Reported Prior to 2023

A breakthrough in periodontitis treatment: Revealing the pharmacodynamic substances and mechanisms of Kouqiangjie formula

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