Pharmacological activities and pharmacokinetic study of hyperoside: A short review

Raza, Aun; Xu, Xiuquan; Sun, Han‐Dong; Tang, Jian; Ouyang, Zhen

doi:10.4314/tjpr.v16i2.30

Cited by 46 publications

(27 citation statements)

References 31 publications

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“…The infusion of its aerial part is applied in the traditional medicine to treat chronic catarrhal affections, asthma, sore throats and cough ( Pieroni et al, 2004 ). Recent scientific evidences indicate that fungi of the phyla Basidiomycetes and Ascomycetes (e.g., Bjerkandera, Aspergillus, Candida , and Saccharomyces ) are causative agents of these pathologies ( Raza et al, 2017 ).…”

Section: Discussionmentioning

confidence: 99%

Extracts From Hypericum hircinum subsp. majus Exert Antifungal Activity Against a Panel of Sensitive and Drug-Resistant Clinical Strains.

et al. 2018

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During the last two decades incidences of fungal infections dramatically increased and the often accompanying failure of available antifungal therapies represents a substantial clinical problem. The urgent need for novel antimycotics called particular attention to the study of natural products. The genus Hypericum includes many species that are used in the traditional medicine to treat pathological states like inflammations and infections caused by fungi. However, despite the diffused use of Hypericum-based products the antifungal potential of the genus is still poorly investigated. In this study five Hypericum species autochthonous of Central and Eastern Europe were evaluated regarding their polyphenolic content, their toxicological safety and their antifungal potential against a broad panel of clinical fungal isolates. LC-MS analysis led to the identification and quantification of 52 compounds, revealing that Hypericum extracts are rich sources of flavonols, benzoates and cinnamates, and of flavan-3-ols. An in-depth screen of the biological activity of crude extracts clearly unveiled H. hircinum subsp. majus as a promising candidate species for the search of novel antifungals. H. hircinum is diffused in the Mediterranean basin from Spain to Turkey where it is traditionally used to prepare a herbal tea indicated for the treatment of respiratory tract disorders, several of which are caused by fungi. Noteworthy, the infusion of H. hircinum subsp. majus excreted broad antifungal activity against Penicillium, Aspergillus and non-albicans Candida isolates comprising strains both sensitive and resistant to fluconazole. Additionally, it showed no cytotoxicity on human cells and the chemical characterization of the H. hircinum subsp. majus infusion revealed high amounts of the metabolite hyperoside. These results scientifically support the traditional use of H. hircinum extracts for the treatment of respiratory tract infections and suggest the presence of exploitable antifungal principles for further investigations aimed at developing novel antifungal therapies.

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Section: Discussionmentioning

confidence: 99%

Extracts From Hypericum hircinum subsp. majus Exert Antifungal Activity Against a Panel of Sensitive and Drug-Resistant Clinical Strains.

et al. 2018

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“…Concentrations of quercetin glycosides, hyperosi and rutin in the leaves of E. longistipitata are higher than those of respective aglycon These glycosides have strong pharmacological activities. For example, numerous in vi and in vivo studies on the biological activity of hyperoside have shown that it exerts an inflammatory, antithrombotic, antidiabetic, antiviral, antifungal, hepatoprotective, a antioxidant protective effects [33]. Rutin is recommended for the treatment of various d orders, especially vascular diseases such as varicose veins, internal bleeding, or hem rhoid.…”

Section: Resultsmentioning

confidence: 99%

Identification of Flavonoids in the Leaves of Eranthis longistipitata (Ranunculaceae) by Liquid Chromatography with High-Resolution Mass Spectrometry (LC-HRMS)

Kostikova

Chernonosov

Кузнецов

et al. 2021

Plants

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Eranthis longistipitata Regel is an endemic plant of Central Asia. The flavonoid profile of E. longistipitata leaves was studied by mass spectrometry for the first time (natural populations of Kyrgyzstan and Uzbekistan, in 70% aqueous–ethanol extracts by liquid chromatography coupled with high-resolution mass spectrometry). Mass spectrometry revealed 18 flavonoid compounds. Flavonols featured the highest diversity, and 10 such substances were identified: 2 free aglycones (quercetin and kaempferol), 6 quercetin glycosides (peltatoside, hyperoside, reynoutrin, quercetin 3-sambubioside, rutin, and isoquercitrin), and 2 kaempferol glycosides (juglalin and trifolin). Two flavans (cianidanol and auriculoside), two hydroxyflavanones (6-methoxytaxifolin and aromadendrin), and one C-glycoside flavone—carlinoside—were identified. Dihydroxychalcones aspalathin, phloridzin, and phloretin were found too. Levels of rutin, quercetin, kaempferol, and hyperoside were confirmed by means of standards and high-performance liquid chromatography. Rutin concentration was the highest among all other identified flavonoid compounds: in the leaf samples from Kyrgyzstan, it ranged from 2.46 to 3.20 mg/g, and in those from Uzbekistan, from 1.50 to 3.01 mg/g. The diversity of flavonoid compounds in E. longistipitata leaves is probably due to external ecological and geographic factors and adaptive mechanisms.

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“…Consequently, it has been shown that the presence of hyperoside in considerable quantity causes anti-oxidative and AChE inhibitory activities in the leaf sample of C.mongolica. Hyperoside widely occurs in the plant kingdom and it demonstrates definite free radical scavenging and oxidative stress protective activity, as well as antiinflammatory, anti-thrombotic, anti-diabetic, anti-viral, anti-fungal and hepatoprotective effects [36][37][38]. In a study by Zhao Y. et al, hyperoside exhibited DPPH scavenging and AChE inhibition activities by the IC 50 , 11.19 µM and 94.61 µM (or 0.0946 mM), respectively, which to a certain degree is comparable to our results.…”

Section: Resultsmentioning

confidence: 99%

Phytochemicals in leaves of Cotoneaster mongolica, their antioxidative, and acetylcholinesterase inhibitory activity

Gendaram

2019

Mong. J. Chem.

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The phytochemicals in the leaves of Cotoneaster mongolica Pojark, as well as their antioxidant and acetylcholinesterase (AChE) inhibitory activity were studied. The methanol extract of the leaves showed acetylcholinesterase inhibitory activity (IC50, 32.61 ± 0.51 μg/mL). The n-butanol fraction of this extract exhibited DPPH radical scavenging (IC50, 55.70 ± 0.15 μg/mL) and AChE inhibitory activity (IC50, 72.50 ± 0.60 μg/mL). From the n-butanol fraction quercetin (1), hyperoside (2), kaempferol-5-O-β-D-glucopyranoside (3), sissotrin (4), ursolic acid (5), corosolic acid (6), euscaphic acid (7), prunasin (8), (2R)-mandeloyl-β-D-glucopyranose (9), (Z)-3-hexenyl-O-α-L-rhamnopyranosyl-(1→6)-β-D-glucopyranoside (10), benzyl-O-α-L-rhamnopyranosyl-(1→6)-β-D-glucopyranoside (11) and arbutin (12) have been isolated and identified. Hyperoside, one of the major constituents among the isolated compounds, was active in both tested assays. Flavonol derivatives could provide the activity of this plant species.

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Pharmacological activities and pharmacokinetic study of hyperoside: A short review

Cited by 46 publications

References 31 publications

Extracts From Hypericum hircinum subsp. majus Exert Antifungal Activity Against a Panel of Sensitive and Drug-Resistant Clinical Strains.

Extracts From Hypericum hircinum subsp. majus Exert Antifungal Activity Against a Panel of Sensitive and Drug-Resistant Clinical Strains.

Identification of Flavonoids in the Leaves of Eranthis longistipitata (Ranunculaceae) by Liquid Chromatography with High-Resolution Mass Spectrometry (LC-HRMS)

Phytochemicals in leaves of Cotoneaster mongolica, their antioxidative, and acetylcholinesterase inhibitory activity

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