Pharmacological actions of the gut active principles in Croton penduliflorus hutch. Seed on isolated smooth and skeletal muscles and on blood pressure

Abstract

The effects of Croton penduliporus seed crystals (CP crystals) were investigated on isolated guinea-pig ileum, chick biventer cervicis muscle and frog rectus abdominis muscle. The effect of the crystals on blood pressure of normotensive Sprague Dawley rats was also investigated. CP crystals induced concentrationsdependent contractions in the guinea-pig ileum with ECS0 of 2.29 X g/mL. Contractions induced by CP crystals in the guinea-pig ileum were not inhibited by atropine (2 X 10-7-l.2 X g/mL), tetrodotoxin (3 X 10-*-2 X lo-' g/mL), hexamethonium (7 X 10-6-2.8 X lo-' g/mL), mepyramine (2 X g/mL) and noradrenaline (2 X lO-'g/mL) but were completely (100%) inhibited by indomethacin (7.2 X 1Oe6g/rnL). CP crystals (1.0 X 10-6-5.0 X g/mL) could not elicit contractions in either chick biventer cervicis or frog rectus abdominis muscle. The mean blood pressure of normotensive Sprague Dawley rats was significantly reduced by CP crystals (1.6Xl0-"-2.5X 10-3g/mL) while the heart rate was significantly reduced by an intravenous infusion of the crystals (2.5 X lo-' g/kg) after 2 min. The methods employed and the significance of the results obtained are discussed.

The effects of oral administration of <i>Croton penduliflorus</i> seed oil and Depo provera on liver and kidney functions of pregnant Dutch-white rabbits

“…It forms a major component of herbal contraceptives, abortifacient and anti-fibroid concoctions used in the local treatment of fibroids (Adjanohoun et al, 1996;Odesanmi et al, 2006). Asuzu and Chineme (1987), Asuzu et al (1988Asuzu et al ( , 1989 indicated that Croton penduliflorus seed oil had irritant effect on the gastrointestinal tract and induced adverse effects on the internal organs including liver and kidneys and central nervous system of mice. It also induced pharmacological effects on isolated smooth and skeletal muscles and blood pressure.…”