Pharmacological action and mechanisms of ginkgolide B

Xia, Shihai; Fang, Dian‐Chun

doi:10.1097/00029330-200705020-00013

Cited by 69 publications

(46 citation statements)

References 51 publications

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“…Ginkgolide B, the major bioactive component of G. biloba extracts, has been reported to play multiple pharmacological roles as mentioned above (11,14,19,21,38,40). Recent studies have found that ginkgolide B may have anticancer properties in molecular, cellular, and whole animal models.…”

Section: Discussionmentioning

confidence: 99%

Ginkgolide B inhibits renal cyst development in in vitro and in vivo cyst models

Zhou

Gao

Zhou

et al. 2012

American Journal of Physiology-Renal Physiology

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Autosomal dominant polycystic kidney disease (ADPKD) is a common inherited disease characterized by massive enlargement of fluid-filled cysts in the kidney. However, there is no effective therapy yet for this disease. To examine whether ginkgolide B, a natural compound, inhibits cyst development, a Madin-Darby canine kidney (MDCK) cyst model, an embryonic kidney cyst model, and a PKD mouse model were used. Interestingly, ginkgolide B significantly inhibited MDCK cyst formation dose dependently, with up to 69% reduction by 2 μM ginkgolide B. Ginkgolide B also significantly inhibited cyst enlargement in the MDCK cyst model, embryonic kidney cyst model, and PKD mouse model. To determine the underlying mechanisms, the effect of ginkgolide B on MDCK cell viability, proliferation, apoptosis, chloride transporter CFTR activity, and intracellular signaling pathways were also studied. Ginkgolide B did not affect cell viability, proliferation, and expression and activity of the chloride transporter CFTR that mediates cyst fluid secretion. Ginkgolide B induced cyst cell differentiation and altered the Ras/MAPK signaling pathway. Taken together, our results demonstrate that ginkgolide B inhibits renal cyst formation and enlargement, suggesting that ginkgolide B might be developed into a novel candidate drug for ADPKD.

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Section: Discussionmentioning

confidence: 99%

Ginkgolide B inhibits renal cyst development in in vitro and in vivo cyst models

Zhou

Gao

Zhou

et al. 2012

American Journal of Physiology-Renal Physiology

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“…Double immunofluorescent staining was performed on sections using antibodies specific for S100 (green a, d, g, j) and PCNA (red b, e, h, k). Merging of the images of S100 and PCNA in the same field (c, f, i, l) demonstrates that Re can promote Schwann cells proliferate after peripheral nerve injury (Color figure online) Cell Mol Neurobiol thrombus and inflammation, and the scavenging oxygen free radicals (Xia and Fang 2007). Another ginsenoside Rg1 promotes peripheral nerve regeneration in rat model of nerve crush injury (Ma et al 2010).…”

Section: Discussionmentioning

confidence: 99%

Ginsenoside Re Promotes Nerve Regeneration by Facilitating the Proliferation, Differentiation and Migration of Schwann Cells via the ERK- and JNK-Dependent Pathway in Rat Model of Sciatic Nerve Crush Injury

et al. 2015

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Exploring effective drugs that are capable of promoting nerve regeneration has gained much attention. Ginsenoside Re (Re) is the main ingredient of ginseng berries and roots. Research in the area has shown that ginsenoside Re exhibits multiple pharmacological activities via different mechanisms both in vivo and in vitro. But the potential therapeutic effects of Re on sciatic nerve crush injury (SNC) have been little investigated. Herein, we investigated the protect effect of Re on peripheral nerve regeneration in a rat SNC model. Walking track analysis revealed that Re treatment significantly promoted functional recovery of crushed sciatic nerve in rats. The expression of PCNA in rat sciatic nerve was up-regulated by Re treatment, and peaked when the concentration of Re was 2.0 mg/kg. Using immunofluorescent staining, we found that Re greatly increased the expression of GAP-43 and S100 in injured rat sciatic nerve. Furthermore, we evaluated the effects of Re on proliferation, differentiation, and migration of Schwann cells in SNC rat models. Our studies reveal that Re promotes nerve regeneration is depend on ERK1/2 and JNK1/2 signaling pathway. Elevated Oct-6 expression and featured morphological changes indicated that Re facilitated the differentiation of Schwann cells following SNC. Also, transwell and wound-healing assay demonstrated that the migration capabilities of Schwann cell were significantly enhanced after Re treatment.

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“…GB, one of the major components of EGb-761, is a specific and potent antagonist of platelet-activating factor (Vargaftig et al, 1980;Vargaftig and Benveniste, 1983;Desquand et al, 1986;Pierre and David, 1991;Paul et al, 1996;Akiba et al, 1998), which is also regarded as having neuroprotective effects in the central nervous system. There is a larger body of data showing that GB possesses a markedly neuroprotective property against ischemia-induced impairment in vivo and in vitro by synergistic mechanisms involving anti-excitotoxicity, inhibition of free radical generation and inflammation, scavenging of reactive oxygen species, and regulation of mitochondrial gene expression (Ling et al, 2002;Maclennan et al, 2002;Qin et al, 2005;Zhang et al, 2006b;Li et al, 2007;Xia and Fang, 2007;Huang et al, 2008;Liu et al, 2010;Yang et al, 2011). However, to date there is a paucity of data available on the influence of GB on ICH.…”

Section: Discussionmentioning

confidence: 99%

“…Over the last decade, substantial scientific evidence has accumulated to suggest that concentrated and partially purified extracts of G. biloba leaves afford protection against some kinds of neural and vascular damage (Maclennan et al, 2002;Xia and Fang, 2007). EGb-761 is a patented extract from the leaves of the G. biloba tree.…”

Section: Introductionmentioning

confidence: 99%

“…There is a large body of data showing that GB possesses a markedly neuroprotective property against ischemia-induced impairment in vivo and in vitro (Ling et al, 2002;Maclennan et al, 2002;Qin et al, 2005;Zhang et al, 2006a;Li et al, 2007;Xia and Fang, 2007;Huang et al, 2008;Liu et al, 2010;Yang et al, 2011). However, there have been few reports on the influence of GB on ICH.…”

Section: Introductionmentioning

confidence: 99%

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Ginkgolide B reduces neuronal cell apoptosis in the hemorrhagic rat brain: Possible involvement of Toll-like receptor 4/nuclear factor-kappa B pathway

Huang

Dong

et al. 2011

Journal of Ethnopharmacology

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Pharmacological action and mechanisms of ginkgolide B

Cited by 69 publications

References 51 publications

Ginkgolide B inhibits renal cyst development in in vitro and in vivo cyst models

Ginkgolide B inhibits renal cyst development in in vitro and in vivo cyst models

Ginsenoside Re Promotes Nerve Regeneration by Facilitating the Proliferation, Differentiation and Migration of Schwann Cells via the ERK- and JNK-Dependent Pathway in Rat Model of Sciatic Nerve Crush Injury

Ginkgolide B reduces neuronal cell apoptosis in the hemorrhagic rat brain: Possible involvement of Toll-like receptor 4/nuclear factor-kappa B pathway

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