Pharmacologic Manipulation of Human Erythrocyte 2,3-Diphosphoglycerate Levels by Prednisone Administration

Silken, Alan B.

doi:10.1203/00006450-197502000-00001

Cited by 5 publications

(1 citation statement)

References 10 publications

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“…Furthermore, some patients may have chronic diseases [ 192 , 193 ] and permanently receive drugs such as different types of hormones [ 170 , 194 , 195 , 196 ], β-adrenoblockers [ 197 ], anesthetics [ 198 ], hydroxychloroquine [ 39 , 199 ], salicylates [ 200 ], and others [ 192 ] which might influence the ODC. Surprisingly, articles on the measurement of ODC/Hb-O 2 affinity in patients with COVID-19 have been published without this information [ 41 ].…”

Section: Potential Causes Of Discrepancies In Available Data and Chal...mentioning

confidence: 99%

Erythrocytes Functionality in SARS-CoV-2 Infection: Potential Link with Alzheimer’s Disease

Kosenko

Tikhonova

Alilova

et al. 2023

IJMS

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Coronavirus disease 2019 (COVID-19) is a rapidly spreading acute respiratory infection caused by SARS-CoV-2. The pathogenesis of the disease remains unclear. Recently, several hypotheses have emerged to explain the mechanism of interaction between SARS-CoV-2 and erythrocytes, and its negative effect on the oxygen-transport function that depends on erythrocyte metabolism, which is responsible for hemoglobin-oxygen affinity (Hb-O2 affinity). In clinical settings, the modulators of the Hb-O2 affinity are not currently measured to assess tissue oxygenation, thereby providing inadequate evaluation of erythrocyte dysfunction in the integrated oxygen-transport system. To discover more about hypoxemia/hypoxia in COVID-19 patients, this review highlights the need for further investigation of the relationship between biochemical aberrations in erythrocytes and oxygen-transport efficiency. Furthermore, patients with severe COVID-19 experience symptoms similar to Alzheimer’s, suggesting that their brains have been altered in ways that increase the likelihood of Alzheimer’s. Mindful of the partly assessed role of structural, metabolic abnormalities that underlie erythrocyte dysfunction in the pathophysiology of Alzheimer’s disease (AD), we further summarize the available data showing that COVID-19 neurocognitive impairments most probably share similar patterns with known mechanisms of brain dysfunctions in AD. Identification of parameters responsible for erythrocyte function that vary under SARS-CoV-2 may contribute to the search for additional components of progressive and irreversible failure in the integrated oxygen-transport system leading to tissue hypoperfusion. This is particularly relevant for the older generation who experience age-related disorders of erythrocyte metabolism and are prone to AD, and provide an opportunity for new personalized therapies to control this deadly infection.

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Section: Potential Causes Of Discrepancies In Available Data and Chal...mentioning

confidence: 99%

Erythrocytes Functionality in SARS-CoV-2 Infection: Potential Link with Alzheimer’s Disease

Kosenko

Tikhonova

Alilova

et al. 2023

IJMS

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Drugs acting on hemoglobin and the oxygen transport system

Norton

Smith

1976

Pharmacology & Therapeutics. Part B: General and Systematic

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Effect of hydrocortisone on the synthesis of 2,3‐diphosphoglycerate in human erythrocytes

Oimomi¹,

Yoshimura

Kubota

et al. 1982

Transfusion

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Studies were carried out on the mechanism of action of glucocorticoids on erythrocyte glycolysis. Inosine increased the levels of 2,3-DPG, lactate, and ATP in red blood cell samples with very low glucose concentrations in which the glycolytic system was unable to utilize glucose. With inosine and hydrocortisone added to red blood cells, 2,3-DPG and lactate increased more than in red blood cells supplemented with inosine alone. There was no significant increase in the level of ATP when glucose and inosine were added compared to the addition of inosine only. There were no changes in the activity of enzymes such as PFK and PGK. From these findings, it is suggested that glucocorticoids increase the level of red blood cell 2,3-DPG, by activating the conversion of 1,3-DPG to 2,3-DPG during glycolysis, probably by stimulating 2,3-DPG mutase.

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Pharmacologic Manipulation of Human Erythrocyte 2,3-Diphosphoglycerate Levels by Prednisone Administration

Cited by 5 publications

References 10 publications

Erythrocytes Functionality in SARS-CoV-2 Infection: Potential Link with Alzheimer’s Disease

Erythrocytes Functionality in SARS-CoV-2 Infection: Potential Link with Alzheimer’s Disease

Drugs acting on hemoglobin and the oxygen transport system

Effect of hydrocortisone on the synthesis of 2,3‐diphosphoglycerate in human erythrocytes

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