2023
DOI: 10.3389/fendo.2022.1043595
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Pharmacologic management of weight regain following bariatric surgery

Abstract: While bariatric surgery restults in significant long-term weight loss for most patients with obesity, post-surgical weight gain affects a considerable percentage of patients to varying degrees of severity. Furthermore, a small but significant percentage of patients experience inadequate post-surgical weight loss. Although many studies have examined the role of anti-obesity medications to address post-operative weight regain, an evidence-based consensus has not yet been achieved because of the heterogeneity of … Show more

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Cited by 17 publications
(8 citation statements)
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References 51 publications
(68 reference statements)
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“…As seen with other chronic diseases like hypertension and diabetes, using a combination of several available therapeutic options is often necessary to obtain optimal goals. For instance, AOMs have been found to be effective adjuncts for post-bariatric weight recurrence [ 3 ]. Several different medications have been used, with data suggesting that glucagon-like-1 receptor agonists (GLP-1RA) may be most effective in these cases [ 4 ].…”
Section: Introductionmentioning
confidence: 99%
“…As seen with other chronic diseases like hypertension and diabetes, using a combination of several available therapeutic options is often necessary to obtain optimal goals. For instance, AOMs have been found to be effective adjuncts for post-bariatric weight recurrence [ 3 ]. Several different medications have been used, with data suggesting that glucagon-like-1 receptor agonists (GLP-1RA) may be most effective in these cases [ 4 ].…”
Section: Introductionmentioning
confidence: 99%
“…Evidence for the safety and effectiveness of MBS and AOMs exists in both adults and children. There is evidence for both the need and effectiveness of using AOM's in adults who have had MBS [ [67] , [68] , [69] , [70] , [71] , [72] ], but the reports suffer from a lack of consistent methods, techniques, and definitions. Despite the variety of responses of adolescents with obesity to MBS and the obvious rationale for using AOM's in some select situations, we could find no reports discussing the use of AOMs after MBS in adolescents.…”
Section: Discussionmentioning
confidence: 99%
“…This section focuses on adolescents who are post-MBS and when they may benefit from the addition of AOM's as an adjunct therapy. The available MBS data for children [ [20] , [21] , [22] , [23] , [24] , 66 ] and adults [ [67] , [68] , [69] , [70] , [71] , [72] ] is examined for the variety of responses to MBS ( Table 2 ). This information is provided as guidance for the pediatric obesity medicine team.…”
Section: Introductionmentioning
confidence: 99%
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“…There are several resources for long-term management of patients after MBS, including recommendations for laboratory evaluation and management of postsurgical complications . Although evidence-based strategies for assisting patients with inadequate weight loss or weight regain after MBS are few, adjunctive treatment with AOMs may provide benefit …”
Section: Mbsmentioning
confidence: 99%