Pharmacologic management of cognitive impairment induced by cancer therapy

Karschnia, Philipp; Parsons, Michael; Dietrich, Jörg

doi:10.1016/s1470-2045(18)30938-0

Cited by 70 publications

(38 citation statements)

References 78 publications

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“…Studies have observed cognitive impairments in cancer patients, which severely affect their daily functioning, QoL and capacity to work (Pendergrass, Targum, & Harrison, 2018). Both pharmacological and non‐pharmacological strategies have been applied to improve the cognitive function in cancer patients (Biegler, Chaoul, & Cohen, 2009; Karschnia, Parsons, & Dietrich, 2019). Peterson et al reported that combined aerobic and cognitive training intervention positively impacted cognitive function in cancer survivors (Peterson et al., 2018).…”

Section: Discussionmentioning

confidence: 99%

Effect of a psychological nursing intervention on quality of life and cognitive function in patients with gastric carcinoma: A randomised controlled trial

et al. 2020

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Gastric carcinoma (GC) is one of the most common digestive cancers and ranked the 2nd most common cause of cancer-related death worldwide (Siegel, Miller, & Jemal, 2017; Sitarz et al., 2018). The incidence rate of GC differs geographically, with more than 40% of the worldwide annual cancer incidences in China (Zhu & Li, 2010). The incidence rate of GC has declined significantly and the overall survival rate of GC has been improved substantially due to the advances of diagnostic technologies and therapeutic strategies in past decades (Bertuccio et al., 2009; Stock & Otto, 2005). Very few symptoms of GC can be observed at early stage, but patients may experience indigestion, stomach pain, cancer-related fatigue, loss of appetite and weight loss at later stage (Zali, Rezaei-Tavirani,

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Section: Discussionmentioning

confidence: 99%

Effect of a psychological nursing intervention on quality of life and cognitive function in patients with gastric carcinoma: A randomised controlled trial

et al. 2020

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“…However, these relevant clinical trials are still lacking. Clinical trials of lithium, pioglitazone, ramipril, docosahexaenoic acid, ibuprofen, and other drugs for CRCI are also ongoing [114].…”

Section: Other Potential Neuroprotectivementioning

confidence: 99%

Pathogenesis, Assessments, and Management of Chemotherapy-Related Cognitive Impairment (CRCI): An Updated Literature Review

Mao

Dong

et al. 2020

Journal of Oncology

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There are various cancer treatments at present, and chemotherapy is one of the main methods. Chemotherapy-related cognitive impairment (CRCI), as one of the side effects of chemotherapy, has gradually attracted the attention of more and more researchers. CRCI has been verified by subjective reports and objective neuropsychological tests so far. But oncologists’ understanding of it and its treatments are still incomplete. In this review, we mainly give a comprehensive overview of the mechanism of CRCI, then describe a variety of evaluation methods, and finally summarize the treatment approaches under current medical conditions and compare it with an excellent article published in 2015 with the aim of providing directions for future research and better understanding of CRCI for clinicians.

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“…Medications such as antidepressants, anxiolytics, and hypnotics may help with coexisting and exacerbating problems. Some studies have shown promise in lessening postchemotherapy cognitive decline and fatigue levels with stimulants such as modafinil (8) and methylphenidate (9), and the efficacy of antidementia drugs such as donepezil and memantine is also being explored (10), with the former seeming to be most useful for treating memory-related symptoms. In addition, studies have pointed to cognitive rehabilitation protocols to address specific cognitive sequelae (11), and physical activity (12) and meditation practices (13) may also be used to lessen CRCI.…”

Section: Cancer Patients and The Postchemotherapy State: Neuropsychologymentioning

confidence: 99%

Long-Term Clinical and Neuronuclear Imaging Sequelae of Cancer Therapy, Trauma, and Brain Injury

et al. 2019

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Learning Objectives: On successful completion of this activity, participants should be able to (1) describe clinical features and therapeutic approaches in the evaluation and management of cancer-and chemotherapy-related cognitive impairment (CRCI), posttraumatic stress disorder (PTSD), and traumatic brain injury (TBI); (2) discuss the role of neuroimaging in contributing to understanding of relationships between clinical features of CRCI, PTSD, and TBI, with aspects of underlying regional cerebral function; and (3) identify which brain processes are most consistently shown to be affected in CRCI, PTSD, and TBI.

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Pharmacologic management of cognitive impairment induced by cancer therapy

Cited by 70 publications

References 78 publications

Effect of a psychological nursing intervention on quality of life and cognitive function in patients with gastric carcinoma: A randomised controlled trial

Effect of a psychological nursing intervention on quality of life and cognitive function in patients with gastric carcinoma: A randomised controlled trial

Pathogenesis, Assessments, and Management of Chemotherapy-Related Cognitive Impairment (CRCI): An Updated Literature Review

Long-Term Clinical and Neuronuclear Imaging Sequelae of Cancer Therapy, Trauma, and Brain Injury

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