Pharmacologic Effects of Wy 27569

Ennis, Christine; Granger, Susan E.; Middlefell, Vicki C.; Philpot, Margaret E.; Shepperson, N.B.

doi:10.1097/00005344-198913040-00001

Cited by 4 publications

(3 citation statements)

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“…There exists considerable interest in the synthesis of new 1,4-dihydropyridines derivatives for their activity as calcium antagonists [3,4] and as candidates for the treatment of multidrug resistance (MDR) during cancer chemotherapy [5], as possible thromboxane synthetase inhibitors [6], PAF-acether antagonists and antithrombotic-antihypertensive agents [7].…”

Section: Introductionmentioning

confidence: 99%

Electrochemical reduction of C-4 nitrosophenyl 1,4-dihydropyridines and their parent C-4 nitrophenyl derivatives in protic media

Núñez‐Vergara

Santander

Navarrete-Encina

et al. 2005

Journal of Electroanalytical Chemistry

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Section: Introductionmentioning

confidence: 99%

Electrochemical reduction of C-4 nitrosophenyl 1,4-dihydropyridines and their parent C-4 nitrophenyl derivatives in protic media

Núñez‐Vergara

Santander

Navarrete-Encina

et al. 2005

Journal of Electroanalytical Chemistry

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“…5,6 At present, compounds related to the 1,4-DHPs are being synthesized to examine new pharmacological properties. [7][8][9][10] In this scope, we have now synthesized a novel series of C-4 nitrosophenyl 1,4dihydropyridines. 11 Our interest in the synthesis of these compounds is based on earlier evidence that some commercial nitrophenyl 1,4-dihydropyridines undergo photolysis when exposed to shortwavelength, visible or UV-C radiation in aqueous solution, giving the corresponding nitroso derivatives.…”

mentioning

confidence: 99%

Electrochemical and ESR Characterization of Free Radicals from C-4 Nitroso Phenyl 1,4-Dihydropyridines in Aprotic Media

Núñez‐Vergara

Santander

Navarrete-Encina

et al. 2006

J. Electrochem. Soc.

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The present paper deals with the electrochemical and electron spin resonance ͑ESR͒ characterization of a number of nitroso phenyl 1,4-dihydropyridines in aprotic media on a hanging drop mercury electrode ͑HDME͒. The electrochemically generated nitroso radical anions decayed by a second-order reaction. Kinetic rate constants varied between k 2 , 4906 ± 43 ͑M s͒ −1 and 17,955 ± 159 ͑M s͒ −1 depending on the chemical structures. An increase in the bulk of the alkyl substituents from methyl-to isopropyl in 3-and 5-positions on the dihydropyridine ring stabilized the free radicals. Also, the electrochemically generated nitro radical anions from the parent nitrophenyl 1,4-dihydropyridines ͑1,4-DHP͒ derivatives were kinetically characterized and were significantly more stable than nitroso derivatives. The time-course of controlled potential electrolysis of the different compounds was followed electrochemically by differential pulse voltammetry, cyclic voltammetry, and spectroscopically by UV-visible and ESR. There is an intermolecular consecutive reaction during electrolysis, which gives the nitranion products. Formation of the one-electron reaction product, i.e., the nitroso radical anion, was confirmed by ESR experiments, and the corresponding hyperfine coupling constants were calculated for all the nitrosophenyl 1, 4-DHP derivatives studied. Universidad de Chile assisted in meeting the publication costs of this article.

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“…Considerable interest in the synthesis of 1,4-dihydropyridines derives from their activity as calcium antagonists and thus for the development of drugs for the treatment of cardiovascular diseases. 4 1,4-Dihydropyridines are also candidates for the treatment of multidrug resistance (MDR) during cancer chemotherapy, 6 as possible thromboxane synthetase inhibitors, 7 PAF-acether antagonists, 8 and antithrombotic-antihypertensive agents. 10 An alternative to the usual means for the synthesis of 1,4-dihydropyridines 2 is the partial reduction 11 of pyridinium salts.…”

mentioning

confidence: 99%