Pharmacologic Effects of Flavonoids on Blood Vessels

Gábor, M

doi:10.1159/000157944

Cited by 23 publications

(17 citation statements)

References 17 publications

(21 reference statements)

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“…In the capillary, they increase its plasticity, decrease its fragility, and ultimately reduce capillary bleeding [23]. In the blood, bioflavonoids reduce the aggregation of red blood cells and platelets [24].…”

Section: Discussionmentioning

confidence: 99%

Myricetin and quercetin are naturally occurring co-substrates of cyclooxygenases in vivo

Bai¹,

Zhu²

2010

Prostaglandins, Leukotrienes and Essential Fatty Acids

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Bioflavonoids are ubiquitously present in the plant kingdom, and some of them are presently being sold as healthy dietary supplements around the world. Recently, it was shown that some of the dietary polyphenols were strong stimulators of the catalytic activity of cyclooxygenase I and II, resulting in increased formation of certain prostaglandin (PG) products in vitro and also in intact cells in culture. In the present study, we investigated the effect of two representative dietary compounds, quercetin and myricetin, on plasma and tissue levels of several PG products in normal Sprague-Dawley rats. We found that these two dietary bioflavonoids could strongly stimulate the formation of PG products in vivo in a time-dependent manner, and the stimulatory effect of these two bioflavonoids was dose-dependent with a unique biphasic pattern. At lower doses (<0.3 mg/kg b.w.), they strongly stimulated the formation of PGE2, but at higher doses (>0.3 mg/kg b.w.), there was a dose-dependent reduction of the stimulatory effect. These results provide support for the hypothesis that some of the bioflavonoids are naturally-occurring physiological co-substrates for the cyclooxygenases in vivo.

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Section: Discussionmentioning

confidence: 99%

Myricetin and quercetin are naturally occurring co-substrates of cyclooxygenases in vivo

Bai¹,

Zhu²

2010

Prostaglandins, Leukotrienes and Essential Fatty Acids

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“…They have been recognized as compounds influencing activity of some enzymes [8, 9]. Moreover, the literature reports their beneficial effect on the microvessel system [10].…”

Section: Introductionmentioning

confidence: 99%

Common cosmetic hydrophilic ingredients as penetration modifiers of flavonoids

Arct

Oborska

Mojski

et al. 2002

Intern J of Cosmetic Sci

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Nowadays, flavonoids are present in many cosmetic formulations, mainly in the form of plant extracts. The main reason of still increasing popularity of these substances is their beneficial biochemical activity. The main factor affecting activity of flavonoids in the skin is their skin penetration ability. The studies have evidenced that flavonoids from grape leaf extract as well as flavonoids like quercetin, rutin and catechin can migrate through the model lipophilic membrane from aqueous solution. The influence of common hydrophilic cosmetic additives on the permeation profile of flavonoids has been checked. The partition coefficients of examined flavonoids in the octanol-water extraction system were determined. Correlations between permeation coefficients and log P of particular flavonoids were plotted. To determine the mechanism of influence of hydrophilic substances on the permeation profile of flavonoids, the solubility of these compounds was investigated. Studies suggest that the presence of hydrophilic additives causes the increase in the flavonoid solubility that decreases the activity of flavonoids in the vehicle. In such a situation, the driving force for the penetration is reduced and the decrease of permeation coefficient can be observed.

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“…Rutin (194), hesperidin and derivatives (20), and polyphloretin phosphate (75) show in vitro hyaluronidase inhibition and also stabilize lysozymes (326). Hyaluronidase inhibition by bioflavonoids and related compounds has been reported (125,207,239).…”

Section: Ascorbic Acid and Host Resistance To Neoplasiamentioning

confidence: 99%

Orthomolecular Medicine

McLeay¹

2001

World Scientific Series in 20th Century Chemistry

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Pharmacologic Effects of Flavonoids on Blood Vessels

Cited by 23 publications

References 17 publications

Myricetin and quercetin are naturally occurring co-substrates of cyclooxygenases in vivo

Myricetin and quercetin are naturally occurring co-substrates of cyclooxygenases in vivo

Common cosmetic hydrophilic ingredients as penetration modifiers of flavonoids

Orthomolecular Medicine

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