Pharmacologic Choices for Procedural Sedation

Takieddine, Sheila; Woolf, Brittany; Stephens, Madeline; Droege, Christopher

doi:10.1097/aia.0b013e31828d58dc

Cited by 1 publication

(2 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Section: Methodsmentioning

confidence: 99%

“…muscle twitching that may resemble seizures), increased eye movements, double vision, increased intraocular pressure, skin rashes, pain and/or redness at the injection site, allergic reactions, hallucinations, depression, anxiety and confusion have also been reported. 39,40 Monitoring of the project. An independent external person performed monitoring at four occasions during the study period: the first visit before inclusion, the second and third visit during ongoing inclusion and the last visit soon after the inclusion was completed.…”

Section: Statisticsmentioning

confidence: 99%

See 1 more Smart Citation

Intravenous S-ketamine’s analgesic efficacy in third molar surgery. A randomized placebo-controlled double-blind clinical trial

Eriksson,

Gordh,

Karlsten

et al. 2023

British Journal of Pain

View full text Add to dashboard Cite

Background In most cases, a combination of paracetamol and ibuprofen are the optimal treatment for postoperative pain in third molar surgery. If stronger analgesia is required, opioids are traditionally administered. In day-case, surgery; however, opioids should be avoided. Thus, the anaesthetic agent S-ketamine in analgesic doses might be preferred. Methods The study was designed as a randomized placebo-controlled double-blind clinical trial. The study enrolled healthy subjects according to the American Society of Anaesthesiologists classification; I or II (ASA), aged 18 to 44 years, with a body weight between 50 and 100 kg. The patients were randomized into three groups where two doses of S-ketamine were compared (high: 0.25 mg/kg or low: 0.125 mg/kg) with placebo (saline). Results A primary outcome of the study was that VAS at 4 h postoperatively, showed no significant difference between the placebo and high-dose S-ketamine group or in the low-dose group. We found a significant difference between the groups for the first 24 h, with a lower VAS-score in the high-dose S-ketamine group. The time to when 50% had taken their first rescue medication was 12 min later in the high-dose ketamine group. Conclusions Pre-emptive S-ketamine 0.25 mg/kg gave a global significant reduction of pain by VAS during the first 24 h postoperatively. The time from end of surgery to first rescue medication were longer in the high-dose ketamine group compared to both low-dose ketamine and placebo groups.

show abstract

Section: Methodsmentioning

confidence: 99%

Section: Statisticsmentioning

confidence: 99%