Pharmacologic Aspects of Adrenocortical Steroids and ACTH in Man

Thorn, George W.; Jenkins, Dalton; Laidlaw, J. C.; Goetz, Frederick C.; Dingman, Joseph F.; Arons, Walter L.; Streeten, David H. P.; McCracken, Brian H.

doi:10.1056/nejm195302192480804

Cited by 40 publications

(25 citation statements)

References 87 publications

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“…It has been clearly established that cortisone, when given in sufficiently large doses, suppresses inflammation (1). In conditions involving acute inflammation, it delays the mobilization of the inflammatory exudate.…”

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confidence: 99%

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Studies on the Pathogenesis of Acute Inflammation

Allison

Smith

Wood

1955

The Journal of Experimental Medicine

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The anti-inflammatory action of cortisone upon the acute cellular response to thermal injury has been systematically studied in the rabbit ear chamber. The hormone has been shown to suppress the reaction of acute inflammation in its earliest recognizable phase; i.e., that involving vasodilatation and the adherence of leucocytes to the vascular endothelium. Evidence has been presented that the anti-inflammatory effect of the hormone cannot be explained on the basis of its vasoconstrictive properties alone. The experimental observations support the hypothesis that cortisone exerts a direct protective action upon endothelial cells and leucocytes, and that in so doing, it renders them refractory to the tissue products which initiate inflammation.

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confidence: 99%

“…This delay, in the ease of certain acute bacterial infections, leads to lowered resistance of the host (2)(3)(4)(5). It may cause dramatic relief of symptoms in certain disease states (1).…”

mentioning

confidence: 99%

Studies on the Pathogenesis of Acute Inflammation

Allison

Smith

Wood

1955

The Journal of Experimental Medicine

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“…Studies of the relationship of adrenal hormones to body fat in lesser animals are so contradictory and difficult to interpret that complete review is redundant for the purpose of this discussion. Concise summaries of published work on the subject, such as those of Thorn and his associates (17), Ingle (18) and Engel and Scott (19) indicate that no clear-cut opinion regarding adrenal-fat relationships can be rendered. Studies C2--wF, Fi--*C3 The present study indicates quite definitely that Compound A has no measurable effect on total body fat.…”

Section: Methodsmentioning

confidence: 99%

The Effects of Compound a (11-Dehydrocorticosterone) and Compound F (17-Hydroxycorticosterone) on Total Body Fat 1

Kyle¹,

Meyer²,

Schaaf³

et al. 1956

J. Clin. Invest.

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“…Their collective work contributed greatly to our understanding of glucocorticoid physiology (30)(31)(32)(33)(34), and this work set the stage for Fred's willingness to continually reevaluate challenging clinical and scientific problems. As an example, the need for appropriate glucocorticoid adjustment during acute illness in a patient with primary adrenal insufficiency was raised during Fred's attending rounds.…”

Section: Early Work With George Thornmentioning

confidence: 99%

“…Many years before the formal National Diabetes Data Group and ADA definitions of diabetes were commonplace, students, fellows, and faculty alike heard Fred comment about the key observations suggesting that diabetes was a heterogeneous disorder with some diabetes characterized by evidence of insulin insufficiency and other forms of diabetes characterized by a diminished effect of circulating insulin or the impact of counterregulatory substances from the pituitary and adrenal glands (31)(32)(33)(34)(35)(36). In an effort to begin to understand this problem, Fred was one of the first investigators to develop insulin assays that could be applied to animal and human studies (37).…”

Section: Career-long Contributions To Understanding B-cell Functionmentioning

confidence: 99%