Pharmacokinetics study of Zr-89-labeled melanin nanoparticle in iron-overload mice

Zhang, Pengjun; Yue, Yuanyuan; Pan, Donghui; Yang, Ronghua; Xu, Yuping; Wang, Lizhen; Yan, Junjie; Li, Xiaotian; Yang, Min

doi:10.1016/j.nucmedbio.2016.05.014

Cited by 20 publications

(6 citation statements)

References 35 publications

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“…Surface-modified NMNPs were prepared by mixing NMNPs with mPEG 2000 -NH 2 (Aladdin Chemicals Co., Ltd., Shanghai, China) at a mass ratio of 1:2 (pH 9.0). 12,25…”

Section: Methodsmentioning

confidence: 99%

Improving the solubility of melanin nanoparticles from apricot kernels is a potent drug delivery system

Gao

Liu

Guo

et al. 2022

Journal of Applied Biomaterials & Functional Materials

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Background: Melanin can be used in biomedical nanomaterials, but its solubility in water and bioavailability are low. Aim: Melanin nanoparticles were prepared and then PEG-natural melanin nanoparticles (NMNP-PEG) were obtained with good performance and optimize their (water solubility, dispersion stability, chelating metal ions, photothermal stability, drug delivery, and biocompatibility), therefore improve the water solubility of melanin and broaden its application scope in biology, medicine, food, and other fields. Methods: MFAK (melanin from apricot kernels) and NMNP-PEG were prepared and characterized using ultraviolet-visible spectrophotometry (UV-Vis), high-performance liquid chromatography (HPLC), Fourier-transform infrared spectroscopy (FTIR), 1H nuclear magnetic resonance (NMR), and electron microscopy. The chelation rate of metal ions, photothermal effect, doxorubicin loading, and cytotoxicity (MCF-7 cells) were examined. Results: UV-Vis, HPLC, FTIR, and NMR indicated that NMNPs contained melanin. NMNPs could be successfully modified using PEG. Under physiological pH conditions (pH 7.4), the metal ion chelation rate of NMNP-PEG increased with time and peaked at 12 h. The photothermal assay showed a temperature enhancement of 26.3°C with 1 mg/mL NMNP-PEG, compared with 1.9℃ with water. The NMNP-PEGs had a typical peak for doxorubicin in the FTIR spectrum, and the peak intensity was proportional to the drug loading. The release of doxorubicin in an acidic buffer was 40.8% at 24 h, almost threefold that in a neutral buffer (11.9%). There was no obvious cytotoxicity from NMNP-PEG. Conclusion: NMNP-PEG displays good stability, high metal ion chelation ability, efficient photothermal conversion potential, drug-retaining capability, sustained controlled drug release, and biocompatibility. This study provides a theoretical basis for NMNP-PEG applications in medicine (targeting specific sites to diagnose and treat diseases), food (extending the shelf life of food), and biology (as metal ion chelating agents to remove heavy metals from wastewater).

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“…Surface-modified NMNPs were prepared by mixing NMNPs with mPEG 2000 -NH 2 (Aladdin Chemicals Co., Ltd., Shanghai, China) at a mass ratio of 1:2 (pH 9.0). 12,25…”

Section: Methodsmentioning

confidence: 99%

Improving the solubility of melanin nanoparticles from apricot kernels is a potent drug delivery system

Gao

Liu

Guo

et al. 2022

Journal of Applied Biomaterials & Functional Materials

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“…Knowing that natural and synthetic melanin NPs are promising candidates as nanocarriers for drug delivery, in this section, examples of melanin NPs PEGylation are presented since it is one of the most exploited post-functionalization strategies. The reason why this functionalization strategy is so popular is that it can prolong the blood circulation half-life of unmodified melanin NPs from 4 h to 15.7 h upon modification [103,104]. It should be highlighted that PEGylation is usually the first post-modification strategy applied and, in most of the cases, it is combined with additional surface functionalizations for a synergistic action [101,105,106].…”

Section: Pegylation For Increased Circulation Time and Improved Targe...mentioning

confidence: 99%

Functionalization of and through Melanin: Strategies and Bio-Applications

Mavridi-Printezi

Menichetti

Mordini

et al. 2023

IJMS

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A unique feature of nanoparticles for bio-application is the ease of achieving multi-functionality through covalent and non-covalent functionalization. In this way, multiple therapeutic actions, including chemical, photothermal and photodynamic activity, can be combined with different bio-imaging modalities, such as magnetic resonance, photoacoustic, and fluorescence imaging, in a theragnostic approach. In this context, melanin-related nanomaterials possess unique features since they are intrinsically biocompatible and, due to their optical and electronic properties, are themselves very efficient photothermal agents, efficient antioxidants, and photoacoustic contrast agents. Moreover, these materials present a unique versatility of functionalization, which makes them ideal for the design of multifunctional platforms for nanomedicine integrating new functions such as drug delivery and controlled release, gene therapy, or contrast ability in magnetic resonance and fluorescence imaging. In this review, the most relevant and recent examples of melanin-based multi-functionalized nanosystems are discussed, highlighting the different methods of functionalization and, in particular, distinguishing pre-functionalization and post-functionalization. In the meantime, the properties of melanin coatings employable for the functionalization of a variety of material substrates are also briefly introduced, especially in order to explain the origin of the versatility of melanin functionalization. In the final part, the most relevant critical issues related to melanin functionalization that may arise during the design of multifunctional melanin-like nanoplatforms for nanomedicine and bio-application are listed and discussed.

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“…Chemotherapeutic agents are the predominant treatment in clinical oncology and penetrate tumor tissue more deeply than nanomaterials. Surface-modified nanoplatforms resembling melanin can effectively combine the benefits of CT and PTT [ 54 ]. MNPs can bind to drugs in a similar manner and serve as a drug delivery system for dose reduction and side effects.…”

Section: Mnps In Oncology Treatmentmentioning

confidence: 99%

Melanin-like nanoparticles: advances in surface modification and tumour photothermal therapy

Tian

et al. 2022

J Nanobiotechnol

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Currently, tumor treatments are characterized by intelligence, diversity and personalization, but the therapeutic reagents used are often limited in clinical efficacy due to problems with water solubility, targeting, stability and multidrug resistance. To remedy these shortcomings, the application of multifunctional nanotechnology in the biomedical field has been widely studied. Synthetic melanin nanoparticles (MNPs) surfaces which contain highly reactive chemical groups such as carboxyl, hydroxyl and amine groups, can be used as a reaction platform on which to graft different functional components. In addition, MNPs easily adhere to substrate surface, and serve as a secondary reaction platform to modify it. The multifunctionality and intrinsic biocompatibility make melanin-like nanoparticles promising as a multifunctional and powerful nanoplatform for oncological applications. This paper first reviews the preparation methods, polymerization mechanisms and physicochemical properties of melanin including natural melanin and chemically synthesized melanin to guide scholars in MNP-based design. Then, recent advances in MNPs especially synthetic polydopamine (PDA) melanin for various medical oncological applications are systematically and thoroughly described, mainly focusing on bioimaging, photothermal therapy (PTT), and drug delivery for tumor therapy. Finally, based on the investigated literature, the current challenges and future directions for clinical translation are reasonably discussed, focusing on the innovative design of MNPs and further elucidation of pharmacokinetics. This paper is a timely and comprehensive and detailed study of the progress of MNPs in tumor therapy, especially PTT, and provides ideas for the design of personalized and customizable oncology nanomedicines to address the heterogeneity of the tumor microenvironment. Graphical Abstract

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Pharmacokinetics study of Zr-89-labeled melanin nanoparticle in iron-overload mice

Cited by 20 publications

References 35 publications

Improving the solubility of melanin nanoparticles from apricot kernels is a potent drug delivery system

Improving the solubility of melanin nanoparticles from apricot kernels is a potent drug delivery system

Functionalization of and through Melanin: Strategies and Bio-Applications

Melanin-like nanoparticles: advances in surface modification and tumour photothermal therapy

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