Pharmacokinetics of two Alternative Dosage Forms for Cyclosporine: Liposomes and Intralipid

Venkataram, S.; Awni, Walid M.; Jordan, Kimberly R.; Rahman, Y.E.

doi:10.1002/jps.2600790307

Cited by 66 publications

(15 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…2). Although the lipid bilayers of vesicles are unstable in the gastrointestinal tract (which may lead to uncontrolled drug release and its precipitation), liposomes have been found to improve the systemic absorption of CsA after oral administration, and can modify their tissue distribution helping to reduce the nephrotoxicity of the drug [52]. Liposomal CsA was reported to be preferably absorbed by Peyer's patches following oral administration [53].…”

Section: Systems For the Oral Delivery Of Cyclosporine Amentioning

confidence: 99%

Oral cyclosporine A - the current picture of its liposomal and other delivery systems

Czogalla¹

2009

Cellular and Molecular Biology Letters

View full text Add to dashboard Cite

Abstract:The discovery of cyclosporine A was a milestone in organ transplantation and the treatment of autoimmune diseases. However, developing an efficient oral delivery system for this drug is complicated by its poor biopharmaceutical characteristics (low solubility and permeability) and the need to carefully monitor its levels in the blood. Current research is exploring various approaches, including those based on emulsions, microspheres, nanoparticles, and liposomes. Although progress has been made, none of the formulations is flawless. This review is a brief description of the main pharmaceutical systems and devices that have been described for the oral delivery of cyclosporine A in the context of the physicochemical properties of the drug and the character of its interactions with lipid membranes.

show abstract

Section: Systems For the Oral Delivery Of Cyclosporine Amentioning

confidence: 99%

Oral cyclosporine A - the current picture of its liposomal and other delivery systems

Czogalla¹

2009

Cellular and Molecular Biology Letters

View full text Add to dashboard Cite

show abstract

“…During recent years, it has been recognized that these systems may also be used as carriers for lipophilic drugs and several formulations have been commercialized (1)(2)(3)(4). Advantages of nanoemulsions include toxicological safety and a high content of the lipid phase as well as the possibility of large-scale production by high-pressure homogenization.…”

Section: Introductionmentioning

confidence: 99%

Comparative Study on the Suitability of Two Techniques for Measuring the Transfer of Lipophilic Drug Models from Lipid Nanoparticles to Lipophilic Acceptors

Dawoud

Hashem

2014

AAPS PharmSciTech

View full text Add to dashboard Cite

Abstract. Due to their particle size in the submicrometer range, lipid nanoparticles are suitable for parenteral administration. In order to obtain information on their potential in vivo performance, a simple and effective in vitro assay to evaluate the drug release behavior of such particles is required. This study compares the use of different experimental setups for this purpose. Lipid nanoparticles from trimyristin which were loaded with fluorescent lipophilic drug models (a temoporfin and Nile red) were used as donor particles. The transfer of the two drug models to multilamellar vesicles (MLV) and emulsion droplets as lipophilic acceptor compartments was examined. The determination of the transferred substance was performed either after separation by centrifugation or by an in situ flow cytometric technique. The transfer of temoporfin was slow to the acceptor MLV and very rapid to the acceptor emulsion. With both acceptors, the transfer of temoporfin stopped at a concentration much lower than the theoretical equilibrium values. The transfer of the less lipophilic drug Nile red was very rapid to both acceptors with equilibrium concentrations close to the expected values. The transfer results of temoporfin especially to the acceptor MLV obtained with the two detection techniques were comparable while the centrifugation technique indicated an apparently higher Nile red transfer rate than the flow cytometric technique. Both techniques are equally suitable to study the transfer of temoporfin, while the flow cytometric technique is advantageous to measure the very rapid transfer of Nile red.

show abstract

“…The SME system has gained increasing importance for the administration of those drugs which are poorly soluble in water and oils and simultaneously toxiferous for intravenous injection. The SME system also enhances the activity and bioavailability of these drugs (3,4). Reports on the ability of these systems to enhance the drug solubility and efficacy and to reduce side effects by incorporating the drug into the lipophilic core (of the oil droplets or in the core of micelles) or in the interface have appeared in the literature (5)(6)(7)(8).…”

Section: Introductionmentioning

confidence: 99%

The Study on the Entrapment Efficiency and In Vitro Release of Puerarin Submicron Emulsion

Yue

Zhang

et al. 2009

AAPS PharmSciTech

View full text Add to dashboard Cite

Abstract. The entrapment efficiency (EE) and release in vitro are very important physicochemical characteristics of puerarin submicron emulsion (SME). In this paper, the performance of ultrafiltration (UF), ultracentrifugation (UC), and microdialysis (MD) for determining the EE of SME were evaluated, respectively. The release study in vitro of puerarin from SME was studied by using MD and pressure UF technology. The EE of SME was 86.5%, 72.8%, and 55.8% as determined by MD, UF, and UC, respectively. MD was not suitable for EE measurements of puerarin submicron oil droplet, which could only determine the total EE of submicron oil droplet and liposomes micelles, but it could be applied to determine the amount of free drug in SMEs. Although UC was the fastest and simplest to use, its results were the least reliable. UF was still the relatively accurate method for EE determination of puerarin SME. The release of puerarin SME could be evaluated by using MD and pressure UF, but MD seemed to be more suitable for the release study of puerarin emulsion. The drug release from puerarin SME at three drug concentrations was initially rapid, but reached a plateau value within 30 min. Drug release of puerarin from the SME occurred via burst release.

show abstract

Pharmacokinetics of two Alternative Dosage Forms for Cyclosporine: Liposomes and Intralipid

Cited by 66 publications

References 13 publications

Oral cyclosporine A - the current picture of its liposomal and other delivery systems

Oral cyclosporine A - the current picture of its liposomal and other delivery systems

Comparative Study on the Suitability of Two Techniques for Measuring the Transfer of Lipophilic Drug Models from Lipid Nanoparticles to Lipophilic Acceptors

The Study on the Entrapment Efficiency and In Vitro Release of Puerarin Submicron Emulsion

Contact Info

Product

Resources

About