Pharmacokinetics of Trichloroethanol and Metabolites and Interconversions Among Variously Referenced Pharmacokinetic Parameters

Dose-Dependent Kinetics of Probenecid in Rhesus Monkeys -Intravenous Bolus Studies

“…In vitro studies using the standard slice-medium method have sug gested that there is active uptake of probene cid by liver slices with a Km equal to 1.9 X I O'1 M [11]. The decreased uptake of drug at the metabolic site in hepatic cells with in creasing dose has also been proposed by Gar rett and Lambert [12] to explain the dose dependency observed for trichloroethanol in dogs.…”

Physicochemical Properties, Solubility, and Protein Binding of Δ9 -Tetrahydrocannabinol

“…Large differences in the bioavailability of tetrahydrocannabinol from various solutions and administrative routes have been reported (2, 3). Metabolism is extremely rapid (4-6) and appears to be even faster than chloral hydrate (7) which has a half-life of 3 min. Nevertheless, tetrahydrocannabinol persists in the plasma for 72 hr after a single intravenous dose (4,5).…”

Some Biochemical Effects of Chloral Hydrate in an Infant with a Tyrosinemia-like Syndrome

“…and that the enzyme may have become more resistant to chloral hydrate or chloral hydrate metabolites. Trichloroacetate is normally a minor metabolite of chloral hydrate, this drug being essentially quantitatively converted to trichloroethanol and trichloroethanolglucuronide ( I , 5). Trichloroacetate was not found at levels which could be detected by gas chromatography-mass spectrometry in any of the control subjects who were investigated in the present work, and this suggests that the patient may metabolize an abnormally large proportion of a dose of chloral hydrate to this acid.…”