Pharmacokinetics of tigecycline in turkeys following different routes of administration

Jasiecka-Mikołajczyk, Agnieszka; Ziółkowski, Hubert; Jaroszewski, Jerzy Jan

doi:10.1111/jvp.12447

Cited by 4 publications

(6 citation statements)

References 33 publications

(37 reference statements)

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“…As would be expected, given the differences in experimental design, the results of our study differ to a greater or lesser extent from those of other studies of the PK of TCs in poultry. In general, the PK of TIG in our chickens was similar to that in turkeys ( Jasiecka-Mikołajczyk et al., 2018 ), although the F was even lower in turkeys.…”

Section: Discussionsupporting

confidence: 70%

“…Broilers were randomly divided into 4 intravenous ( IV ) and 4 oral ( PO ) groups. Each group consisted of 6 birds, excluding the TIG PO group which was composed of 12 broilers due to very low PO bioavailability ( F ) of TIG ( Jasiecka-Mokołajczyk et al., 2018 ). Therefore, the number of birds in the TIG PO group was doubled to obtain the most accurate results.…”

Section: Methodsmentioning

confidence: 99%

“…To date, most PK studies have investigated only a single TC ( Anadón et al., 1985 , 2012 ; Grabowski, 2001 ; Ziółkowski et al., 2016 ; Jasiecka-Mikołajczyk et al., 2018 ), whereas studies that have analyzed several agents and animal species have rarely been carried out ( Ziv et al., 1974 ; Nielsen and Gyrd-Hansen, 1996 ). Studying one TC at a time has certain disadvantages because, when comparing such studies, it is difficult to account for the effects of breed, age (which is particularly important in fast growing animals like broiler chickens) ( Poźniak et al., 2017 ), diet, pharmaceutical form of the drug (in particular, products that do not contain a pure substance) ( Thakkar and Desai, 2015 ), or applied dosage ( Caccia et al., 1990 ).…”

Section: Introductionmentioning

confidence: 99%

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Comparative pharmacokinetics of chlortetracycline, tetracycline, minocycline, and tigecycline in broiler chickens

et al. 2020

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Tetracyclines continue to be important antimicrobials in veterinary medicine. However, the pharmacokinetics ( PK ) of tigecycline ( TIG ) and minocycline ( MIN ) in broiler chickens has not been investigated to date, and the PK of chlortetracycline ( CTC ) and tetracycline ( TET ) remains insufficiently researched, especially in terms of absorption. These antimicrobials have never been compared in a single setting in a single species; therefore, the aim of the present study was to compare the PK of TIG, MIN, CTC, and TET in broiler chickens. Each drug (10 mg/kg) was administered intravenously ( IV ) and orally ( PO ). The plasma concentrations of each drug were determined by liquid chromatography-tandem mass spectrometry, and the results were analyzed using compartmental and non-compartmental PK models. Despite the fact that all of the studied antimicrobials were administered at an identical IV dose, the area under the concentration–time curve between zero and the last sampling point (AUC 0→t ) for MIN (35,014 ± 3,274 μg × hour/mL) and CTC (41,851 ± 10,965 μg × hour/mL) differed significantly from that determined for TIG (18,866 ± 4,326 μg × hour/mL) and TET (17,817 ± 4,469 μg × hour/mL). After IV administration, the values of AUC 0→t were also directly related to total body clearance values which were significantly higher for TIG (0.56 ± 0.14 L/hour × kg) and TET (0.60 ± 0.14 L/hour × kg) than for CTC (0.25 ± 0.05 L/hour × kg) and MIN (0.29 ± 0.03 L/hour × kg). In turn, after PO administration, TIG was absorbed in only 1.55% ± 0.82, and CTC in 30.54% ± 6.99, whereas the bioavailability of MIN and TET was relatively high at 52.33% ± 3.92 and 56.45% ± 9.71, respectively. The differences in PK parameters between these drugs, despite their structural similarities, suggest that active transport mechanisms may play a role in their absorption and distribution.

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Section: Discussionsupporting

confidence: 70%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Comparative pharmacokinetics of chlortetracycline, tetracycline, minocycline, and tigecycline in broiler chickens

et al. 2020

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“…These analyses were performed using methods previously described by Onichimowski et al [6]. Tigecycline was extracted from plasma samples according to Jasiecka et al except for the use of tigecycline-d9 as an internal standard (instead of minocycline) [14]. Ciprofloxacin was extracted according to Ziółkowski et al [15].…”

Section: Drug Analysismentioning

confidence: 99%

Adsorption of vancomycin, gentamycin, ciprofloxacin and tygecycline on the filters in continuous renal replacement therapy circuits: in full blood in vitro study

et al. 2020

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The aim of this study was to assess the in vitro adsorption of antibiotics: vancomycin, gentamicin, ciprofloxacin and tigecycline on both polyethyleneimine-treated polyacrylonitrile membrane of AN69ST filter and polysulfone membrane of AV1000 filter using porcine blood as a model close to in vivo conditions. The porcine blood with antibiotic dissolved in it was pumped into hemofiltration circuit (with AN69ST or AV1000 filter), ultrafiltration fluid was continuously returned to the reservoir containing blood with antibiotic. Blood samples to determine antibiotic concentrations were taken at minutes 0, 5, 15, 30, 45, 60, 90 and 120 from the pre- blood pump of the hemofiltration circuit. To assess possible spontaneous degradation of the drug in the solution there was an additional reservoir prepared for each antibiotic, containing blood with the drug, which was not connected to the circuit. In the case of vancomycin, ciprofloxacine and tigecycline, a statistically significant decrease in the drug concentration in the hemofiltration circuit in comparison to initial value as well as to the concentrations in the control blood was observed, both for polyacrylonitrile and plolysulfone membrane. In the case of gentamicin, significant adsorption was noted only on polyacrylonitrile membrane. Our studies demonstrated that in full blood adsorption of antibiotics may be big enough to be of clinical significance. In particular in the case of polyacrylonitrile membrane.

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“…Tetracyclines can not only be photoactivated under illumination and eradicate bacteria but also inhibit ribosomes to prevent bacterial regrowth [ 10 ]. The low absorption rate of TGC after oral administration [ 11 ] and the poor efficacy in the treatment of gastrointestinal infections except in turkeys after oral administration [ 12 ] may be important reasons explaining why TGC is not widely used in veterinary medicine, but many reports investigate TGC resistance. Chromosome-encoded efflux pump-mediated and plasmid-mediated variants of the resistance gene tet(X) cause TGC resistance to rapidly become prevalent [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Concurrent Determination of Tigecycline, Tetracyclines and Their 4-Epimer Derivatives in Chicken Muscle Isolated from a Reversed-Phase Chromatography System Using Tandem Mass Spectrometry

et al. 2022

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A quantitative and qualitative method using a high-performance liquid chromatography–tandem mass spectrometry (HPLC–MS/MS) detection approach was developed and validated for the analysis of tigecycline, four tetracyclines and their three 4-epimer derivatives in chicken muscle. Samples were extracted repeatedly with 0.1 mol/L Na2EDTA–McIlvaine buffer solution. After vortexing, centrifugation, solid-phase extraction, evaporation and reconstitution, the aliquots were separated using a C8 reversed-phase column (50 mm × 2.1 mm, 5 µm) with a binary solvent system consisting of methanol and 0.01 mol/L trichloroacetic acid aqueous solution. The typical validation parameters were evaluated in accordance with the acceptance criteria detailed in the guidelines of the EU Commission Decision 2002/657/EC and the U.S. Food and Drug Administration Bioanalytical Method Validation 05/24/18. The matrix-matched calibration curve was linear over the concentration range from the limit of quantitation (LOQ) to 400 μg/kg for doxycycline, and the calibration graphs for tetracycline, chlortetracycline, oxytetracycline, their 4-epimer derivatives and tigecycline showed a good linear relationship within the concentration range from the LOQ to 200 μg/kg. The limits of detection (LODs) for the eight targets were in the range of 0.06 to 0.09 μg/kg, and the recoveries from the fortified blank samples were in the range of 89% to 98%. The within-run precision and between-run precision, which were expressed as the relative standard deviations, were less than 5.0% and 6.9%, respectively. The applicability was successfully demonstrated through the determination of residues in 72 commercial chicken samples purchased from different sources. This approach provides a novel option for the detection of residues in animal-derived food safety monitoring.

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Pharmacokinetics of tigecycline in turkeys following different routes of administration

Cited by 4 publications

References 33 publications

Comparative pharmacokinetics of chlortetracycline, tetracycline, minocycline, and tigecycline in broiler chickens

Comparative pharmacokinetics of chlortetracycline, tetracycline, minocycline, and tigecycline in broiler chickens

Adsorption of vancomycin, gentamycin, ciprofloxacin and tygecycline on the filters in continuous renal replacement therapy circuits: in full blood in vitro study

Concurrent Determination of Tigecycline, Tetracyclines and Their 4-Epimer Derivatives in Chicken Muscle Isolated from a Reversed-Phase Chromatography System Using Tandem Mass Spectrometry

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