Abstract:Objective: To determine the pharmacokinetics (PK) and detect changes in cardiac uptake of [123I]IAZA, a radiopharmaceutical used to image focal tissue hypoxia, in healthy volunteers after exercise-based cardiac stress, to establish a rational basis for studies of focal myocardial hypoxia in cardiac patients using [123I]IAZA. Method: Three healthy male volunteers ran the ‘Bruce’ treadmill protocol (criterion heart rate is 85 % of [220 – age]). … Show more
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