Pharmacokinetics of ^99MTC‐myocardial perfusion agents in different species

Linkage Isomerization of MSCN(CDOH)2(CDO)BMe to MNCS(CDOH)2(CDO)BMe (M = Tc, Re). Crystal Structures of TcNCS(CDOH)2(CDO)BMe, ReNCS(CDOH)2(CDO)BMe, and ReSCN(CDOH)2(CDO)BMe

“…7 The boronic acid adducts of technetium dioxime complexes (better known as BATOs) were developed as myocardial and cerebral perfusion imaging agents. 10,11 The seventh ligand is susceptible to hydrolysis at pH 6 and higher, yielding hydroxide in the seventh coordination site. 12 The rates of hydrolysis of the seventh ligand are dependent on the identity of this group, with slower rates observed for smaller and harder ligands.…”

“…The boronic acid adducts of technetium dioxime complexes (better known as BATOs) were developed as myocardial and cerebral perfusion imaging agents. , The seventh ligand is susceptible to hydrolysis at pH 6 and higher, yielding hydroxide in the seventh coordination site .…”

Alkaline Earth Metal and Lanthanide(III) Complexes of Ligands Based upon 1,4,7,10-Tetraazacyclododecane-1,7-bis(acetic acid)

“…A lower dose could be employed if the contrast agent were delivered to a specific organ, tissue, or cell type, resulting in a high localized concentration. The development of organ/tissue-specific radiopharmaceutical agents allows diagnostic evaluation of hepatobiliary and kidney function and brain, myocardial, and bone imaging, , mostly using 99 Tc-based complexes, ,− while radiotherapeutic agents involving 90 Y III -labeled monoclonal antibodies have also been developed. − Tissue-specific delivery of Gd III -based MRI contrast agents could be designed through variation of the lipophilicity, molecular weight, and ionic charge of the chelate. − …”

“…[4][5][6][7][8] Tissue-specific delivery of Gd III -based MRI contrast agents could be designed through variation of the lipophilicity, molecular weight, and ionic charge of the chelate. [18][19][20] Previous reports have described the synthesis, physicochemical characterization, 21 and biodistribution studies 22 of positively charged Gd III chelates, which show promising bone-targeted specificity. One of them is the hexadentate DOTA analogue DO2A (see Figure 1).…”

Technetium and rhenium: coordination chemistry and nuclear medical applications

“…Figure 3D) . 20 Since most representatives of the latter class of compounds are highly lipophilic and the assumed Cl -/H 2 O exchange is slow, a significant fraction of the injected compound is able to cross the blood brain barrier. The obvious lack of a specific trapping mechanism in the brain tissue and the slow blood clearance of such complexes are the main reasons that further developments of BATO-based brainimaging agents have been terminated.…”