Pharmacokinetics of sulfamonomethoxine in tongue sole (Cynoglossus semilaevis) after intravenous and oral administration

Abstract

The pharmacokinetic profiles of sulfamonomethoxine (SMM) were investigated in flatfish tongue soles in the present study. After a single injection of SMM (40 mg/kg BW) to caudal vein of tongue sole at 20 °C, plasma drug concentration versus time data were best fitted to a three-compartment model, characterized with 0.2, 5.7, and 80.4 h for the half-life (t 1/2) of fast distribution, slow distribution, and elimination, respectively. The apparent volume of distribution was 0.1 L/kg, and the body clearance was 0.03 L/h/kg. After oral administration of SMM (200 mg/kg BW) to tongue soles at 20 °C, plasma drug concentrations were best fitted to a two-compartment model, of which the mean half-life of absorption (t 1/2ka) and elimination (t 1/2β ) were 1.7 and 95.7 h, respectively. The maximal absorption concentration (C max) was estimated as 58 mg/L at 2.5 h, and the mean systemic bioavailability (F) was 39.5 % in tongue soles after oral administration.

Pharmacokinetic studies on Sulfamonomethoxine in rabbits

“…In current study, the volume of distribution of SMM in healthy rabbits following IV injection was 0.15 ± 0.003 ml/kg, which was lower than that obtained in tongue sole by Chang et al (2014) (100 ml/kg), Eel (140 ml/kg) (Ryuji, 1988) and horse (390 ml/kg) (Card et al, 1993),while Bobrov et al (1978) investigated a higher value (0.23) in rabbits after IV injection of 10mg/kg. These variations could be attributed to the use of a different rabbit breed and/or a different assay method.…”

“…In current study the peak plasma concentration (C max ) in rabbits following PO administration was 114.06 µg/ ml, which was higher than that recorded by Elbadawy et al, (2015) (2.15),pig (6.68 µg/ ml) (Kokue et al, 1988) and horse (32.3 µg/ ml) (Card et al, 1993). However, the smaller C max value at 206.7 μg/mL has been reported in broiler (Li et al, 1995) and tongue sole (58000 μg/mL) (Chang et al, 2014).…”

“…The obtained data showed that the AUC of SMM following a single IV injection of SMM (20mg/kg) in healthy rabbits was 376.60µg/ml/h ,which higher than the data reported by Kokue et al (1988), Shimoda et al (1983) and Tsuboi et al (1984) (131,81.5 and 186.2 µg/ml/h) in pig, , goat (49.9 µg/ml/h) (Elbadawy et al, 2015) and horse (0.27 µg/ml/h) (Card et al, 1993) ,while this data was lower than data reported in tongue sole by Chang et al (2014Chang et al ( ) (1930 3 µg/ml/h) and Eel (59.1 µg/ml/h) (Ryuji, 1988) The present study showed that the total body clearance (CL) of SMM in rabbits (0.05 ml/kg/h) was higher than that in horse (0.02) (Card et al, 1993). In contrast, the (CL) of SMM in this study was lower than that reported in Eel by Ryuji (1988) (3.38 ml/kg/h), tongue sole (30 ml/kg/h) (Chang et al, 2014), goat (212 ml/kg/h) (Elbadawy et al, 2015) and rabbits (Bobrov et al, 1978) (0.06 ml/kg/h). These variations could be attributed to the use of a different rabbit breed and/or a different assay method.…”

“…In the present study, plasma concentrations of SMM in rabbits after oral administration (20mg/kg) were best described by one compartment model. Sulfamonomethoxine was rapidly absorbed (T max = 0.12h) in healthy rabbits after PO administration which was lower than that in pig (1.55h) (Kokue et al, 1988), horse (1.58h) (Card et al, 1993),broiler (4.39h) (Li et al, 1995), goat (5.6h) (Elbadawy et al, 2015) and tongue sole (2.5h) (Chang et al, 2014).…”

“…While Elbadawy et al (2015) reported a shorter half-life (1h) in goat after IV administration of 10mg/kg. In contrast, Ryuji (1988) reported longer value (86.6 h) in Eel, horse (3.6h) Card et al (1993), pig (3.11h) (Shimoda et al, 1983), tongue sole (80.4h) (Chang et al, 2014) and rainbow trout (30.9 h) or yellowtail (5.8 h) (Uno et al, 1997).…”