Pharmacokinetics of Sodium Selenite Administered Orally in Blood and Tissues of Selenium-Deficient Ducklings

Zheng, Shufang; Xing, Houjuan; Zhang, Qiaojian; Hou, Xue; Zhu, Fating; Xu, Shiwen

doi:10.1007/s12011-018-1567-8

Cited by 9 publications

(4 citation statements)

References 29 publications

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“…Generally, animal feeds are supplemented with inorganic forms of Se such as, sodium selenite [28]. Considering its potential toxicity and interactions with other minerals, dietary levels of sodium selenite are very cautiously determined [29,30].…”

Section: Discussionmentioning

confidence: 99%

Selenium Treatment Enhanced Clearance of Salmonella in Chicken Macrophages (HD11)

et al. 2019

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As an important micronutrient, selenium (Se) plays many essential roles in immune response and protection against pathogens in humans and animals, but underlying mechanisms of Se-based control of salmonella growth within macrophages remain poorly elucidated. In this study, using RNA-seq analyses, we demonstrate that Se treatment (at an appropriate concentration) can modulate the global transcriptome of chicken macrophages HD11. The bioinformatic analyses (KEGG pathway analysis) revealed that the differentially expressed genes (DEGs) were mainly enriched in retinol and glutathione metabolism, revealing that Se may be associated with retinol and glutathione metabolism. Meanwhile, Se treatment increased the number of salmonella invading the HD11 cells, but reduced the number of salmonella within HD11 cells, suggesting that enhanced clearance of salmonella within HD11 cells was potentially modulated by Se treatment. Furthermore, RNA-seq analyses also revealed that nine genes including SIVA1, FAS, and HMOX1 were differentially expressed in HD11 cells infected with salmonella following Se treatment, and GO enrichment analysis showed that these DEGs were mainly enriched in an extrinsic apoptotic signaling pathway. In summary, these results indicate that Se treatment may not only affect retinol and glutathione metabolism in macrophages, but could also inhibit salmonella-induced macrophage apoptosis via an extrinsic apoptotic signaling pathway involving SIVA1.

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Section: Discussionmentioning

confidence: 99%

Selenium Treatment Enhanced Clearance of Salmonella in Chicken Macrophages (HD11)

et al. 2019

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“…As blood is a transporting medium, the concentration of Se could be dramatically changed depending on food intake. Moreover, the buffering system of blood could be insufficient for higher doses of Se due to depletion of transport proteins, and non-deposited Se is excreted by urinary secretion [28,29]. On the other hand, the significantly higher concentration of Se in the SeNP-treated groups compared to the control group was observed in the liver, which isone of the the main depot organ for selenium [30].…”

Section: Discussionmentioning

confidence: 99%

Effects of Sub-Lethal Doses of Selenium Nanoparticles on the Health Status of Rats

Urbánková

Skaličková

Přibilová

et al. 2021

Toxics

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Selenium nanoparticles (SeNPs) are fast becoming a key instrument in several applications such as medicine or nutrition. Questions have been raised about the safety of their use. Male rats were fed for 28 days on a monodiet containing 0.5, 1.5, 3.0 and 5.0 mg Se/kg. Se content in blood and liver, liver panel tests, blood glucose, total antioxidant capacity (TAC), the activity of superoxide dismutase (SOD) and glutathione peroxidase (GPx) were analysed. Liver and duodenum were subjected to histopathology examination. The weight gain of rats showed no differences between tested groups. Se content in blood was higher in all treated groups compared to the control group. The liver concentration of Se in the treated groups varied in the range from 222 to 238 ng/g. No differences were observed in the activity of AST (aspartate aminotransferase), ALP (alkaline phosphatase) and TAS (total antioxidant status). A significant decrease in ALT activity compared to the control group was observed in the treated groups. GPx activity varied from 80 to 88 U/mL through tested groups. SOD activity in liver was decreased in the SeNP-treated group with 5 mg Se/kg (929 ± 103 U/mL). Histopathological examination showed damage to the liver parenchyma and intestinal epithelium in a dose-dependent manner. This study suggests that short-term SeNP supplementation can be safe and beneficial in Se deficiency or specific treatment.

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“…Further, MeSeCys has minor sub-chronic oral toxicity and no genotoxicity at doses far above the daily nutritional Se level (0.5, 0.7, 0.9 mg per kg of body weight) after 90-day oral exposure [ 436 ]. Although the pharmacokinetics of sodium selenite has been investigated in various animal models, the biosafety dose of Se is still unclear due to the narrow safe dose range of Se and the distinct animal physiological and pathological conditions [ 437 ]. For instance, selenium-enriched yeast (SeY) had higher bioavailability in rats than sodium selenite, while plasma-free SeMet was found to be the ideal biomarker of SeY status in vivo [ 438 ].…”

Section: Pharmacokinetics and Cellular Interactions Of Selenium Nanop...mentioning

confidence: 99%

Biogenic Selenium Nanoparticles in Biomedical Sciences: Properties, Current Trends, Novel Opportunities and Emerging Challenges in Theranostic Nanomedicine

et al. 2023

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Selenium is an important dietary supplement and an essential trace element incorporated into selenoproteins with growth-modulating properties and cytotoxic mechanisms of action. However, different compounds of selenium usually possess a narrow nutritional or therapeutic window with a low degree of absorption and delicate safety margins, depending on the dose and the chemical form in which they are provided to the organism. Hence, selenium nanoparticles (SeNPs) are emerging as a novel therapeutic and diagnostic platform with decreased toxicity and the capacity to enhance the biological properties of Se-based compounds. Consistent with the exciting possibilities offered by nanotechnology in the diagnosis, treatment, and prevention of diseases, SeNPs are useful tools in current biomedical research with exceptional benefits as potential therapeutics, with enhanced bioavailability, improved targeting, and effectiveness against oxidative stress and inflammation-mediated disorders. In view of the need for developing eco-friendly, inexpensive, simple, and high-throughput biomedical agents that can also ally with theranostic purposes and exhibit negligible side effects, biogenic SeNPs are receiving special attention. The present manuscript aims to be a reference in its kind by providing the readership with a thorough and comprehensive review that emphasizes the current, yet expanding, possibilities offered by biogenic SeNPs in the biomedical field and the promise they hold among selenium-derived products to, eventually, elicit future developments. First, the present review recalls the physiological importance of selenium as an oligo-element and introduces the unique biological, physicochemical, optoelectronic, and catalytic properties of Se nanomaterials. Then, it addresses the significance of nanosizing on pharmacological activity (pharmacokinetics and pharmacodynamics) and cellular interactions of SeNPs. Importantly, it discusses in detail the role of biosynthesized SeNPs as innovative theranostic agents for personalized nanomedicine-based therapies. Finally, this review explores the role of biogenic SeNPs in the ongoing context of the SARS-CoV-2 pandemic and presents key prospects in translational nanomedicine.

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Pharmacokinetics of Sodium Selenite Administered Orally in Blood and Tissues of Selenium-Deficient Ducklings

Cited by 9 publications

References 29 publications

Selenium Treatment Enhanced Clearance of Salmonella in Chicken Macrophages (HD11)

Selenium Treatment Enhanced Clearance of Salmonella in Chicken Macrophages (HD11)

Effects of Sub-Lethal Doses of Selenium Nanoparticles on the Health Status of Rats

Biogenic Selenium Nanoparticles in Biomedical Sciences: Properties, Current Trends, Novel Opportunities and Emerging Challenges in Theranostic Nanomedicine

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