Pharmacokinetics of Single Doses of Methadone and Buprenorphine in Blood and Oral Fluid in Healthy Volunteers and Correlation With Effects on Psychomotor and Cognitive Functions

Strand, Maren Cecilie; Ramaekers, J.G.; Gjerde, Hallvard; Mørland, Jörg; Vindenes, Vigdis

doi:10.1097/jcp.0000000000001077

Cited by 3 publications

(2 citation statements)

References 88 publications

(98 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…If a drug is ingested recently, very high concentrations can be detected in OF (Crouch 2005). In our laboratory we have experienced very high concentrations of buprenorphine in OF in some cases (131). Actually, the concentrations were so high that the laboratory analyzing the OF sample experienced difficulties.…”

Section: Can Measurement Of Of Zopiclone Concentration Substitute Blomentioning

confidence: 90%

“…Psychomotor testing can detect deteriorated performance due to other impairing effects that are not revealed in the on-the road driving test. In a recent study that investigated impairment of buprenorphine, even more impairment was found for the psychomotor testing than measurement of the SDLP in the on-the-road driving test (131).…”

Section: Measurement Of Impairment In An Experimental Settingmentioning

confidence: 98%

See 1 more Smart Citation

Zopiclone concentrations in oral fluid and blood after, administration of therapeutic doses of zopiclone

Hjelmeland

Gustavsen

Øiestad

et al. 2017

Forensic Science International

Self Cite

View full text Add to dashboard Cite

Vast intra- and interindividual differences in ZOBCR were found, and the correlation between OF and blood concentration was less pronounced than reported in former studies. In accordance with earlier studies we found a negative correlation between ZOBCR and OF volume. The ZOBCR decreases in relation to recent intake of a meal, probably because stimulated saliva production causes "dilution" of saliva. OF zopiclone concentration appeared unsuitable for estimation of blood zopiclone concentration. Due to long detection time, analysis of zopiclone in OF might be useful to detect non-recent, previous intake.

show abstract

Section: Can Measurement Of Of Zopiclone Concentration Substitute Blomentioning

confidence: 90%

Section: Measurement Of Impairment In An Experimental Settingmentioning

confidence: 98%

Zopiclone concentrations in oral fluid and blood after, administration of therapeutic doses of zopiclone

Hjelmeland

Gustavsen

Øiestad

et al. 2017

Forensic Science International

Self Cite

View full text Add to dashboard Cite

show abstract

Conductive vial electromembrane extraction of opioids from oral fluid

et al. 2023

View full text Add to dashboard Cite

The use of oral fluid as sample matrix has gained significance in the analysis of drugs of abuse due to its non-invasive nature. In this study, the 13 opioids morphine, oxycodone, codeine, O-desmethyl tramadol, ethylmorphine, tramadol, pethidine, ketobemidone, buprenorphine, fentanyl, cyclopropylfentanyl, etonitazepyne, and methadone were extracted from oral fluid using electromembrane extraction based on conductive vials prior to analysis with ultra-high performance liquid chromatography–tandem mass spectrometry. Oral fluid was collected using Quantisal collection kits. By applying voltage, target analytes were extracted from oral fluid samples diluted with 0.1% formic acid, across a liquid membrane and into a 300 μL 0.1% (v/v) formic acid solution. The liquid membrane comprised 8 μL membrane solvent immobilized in the pores of a flat porous polypropylene membrane. The membrane solvent was a mixture of 6-methylcoumarin, thymol, and 2-nitrophenyloctyl ether. The composition of the membrane solvent was found to be the most important parameter to achieve simultaneous extraction of all target opioids, which had predicted log P values in the range from 0.7 to 5.0. The method was validated in accordance to the guidelines by the European Medical Agency with satisfactory results. Intra- and inter-day precision and bias were within guideline limits of ± 15% for 12 of 13 compounds. Extraction recoveries ranged from 39 to 104% (CV ≤ 23%). Internal standard normalized matrix effects were in the range from 88 to 103% (CV ≤ 5%). Quantitative results of authentic oral fluid samples were in accordance with a routine screening method, and external quality control samples for both hydrophilic and lipophilic compounds were within acceptable limits.

show abstract

Review of LC techniques for determination of methadone and its metabolite in the biological samples

Shan

Zhang

Yang

2021

Preparative Biochemistry & Biotechnology

View full text Add to dashboard Cite

Pharmacokinetics of Single Doses of Methadone and Buprenorphine in Blood and Oral Fluid in Healthy Volunteers and Correlation With Effects on Psychomotor and Cognitive Functions

Abstract: Maren Cecilie Strand, M.D. and specialist in clinical pharmacology, and prof.dr. Johannes Ramaekers, and that they had direct clinical responsibility for patients.

Cited by 3 publications

References 88 publications

Zopiclone concentrations in oral fluid and blood after, administration of therapeutic doses of zopiclone

Zopiclone concentrations in oral fluid and blood after, administration of therapeutic doses of zopiclone

Conductive vial electromembrane extraction of opioids from oral fluid

Review of LC techniques for determination of methadone and its metabolite in the biological samples

Contact Info

Product

Resources

About