Pharmacokinetics of recombinant human erythropoietin in children treated with continuous ambulatory peritoneal dialysis

Abstract

In children on CAPD the resorption of erythropoietin after intraperitoneal administration, measured as AUC, is similar to subcutaneous administration, when erythropoietin is administered in 50 ml of dialysate. The dose needed to treat renal anaemia with erythropoietin administered intraperitoneally this way will have to be established in a therapeutic study.

Intraperitoneal treatment with darbepoetin for children on peritoneal dialysis

“…This may explain the differences observed with respect to darbepoetin doses. Since the bioavailability of subcutaneous and intraperitoneal erythropoietin is comparable [10], a similar behavior pattern of darbepoetin can be expected.…”

“…Erythropoietin is administered during the daytime in a small amount of dialysis solution, which is effective and safe [9][10][11]. Administration of darbepoetin once weekly is easier, less time-consuming, and theoretically safer because disconnections of the system are less frequent.…”

Long-Term Effectiveness of Intraperitoneal Erythropoietin in Children on Nipd by Administration in Small Bags

“…The main disadvantage of intraperitoneal administration of EPO seems to be the need for higher maintenance doses. However, it was established that the absorption of EPO after intraperitoneal administration is similar to absorption after subcutaneous administration if the EPO is added to a small volume (50 mL) of dialysis fluid (2,5,6).…”

The management of anemia in pediatric peritoneal dialysis patients

“…If erythropoietin is administered in a small volume of dialysis fluid (50-ml bags are commercially available), bioavailability is similar to that after subcutaneous administration of the same amount of hormone [25] ( evidence ). Mean dosage needed for maintaining the target hematocrit decreased from 279 to 194 U/kg/week if the drug was administered in a 50-ml dialysis bag during the daytime [26, 27].…”