Abstract:The pharmacokinetics of practolol were studied after intravenous injection (5 mg/kg) in conscious normal rabbits and rabbits with experimental glomerulonephritis induced by daily intravenous injection of bovine 7-globulin. The results obtained demonstrated that the practolol elimination was impaired in animals with experimental glomerulonephritis: significant lengthening of the half-life of the β-phase, with marked decrease of the body clearance and diminution of the drug concentration decrease in plasma. Neit… Show more
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