Pharmacokinetics of pefloxacin mesylate in human urine using capillary electrophoresis electrochemiluminescence detection

Deng, Biyang; Li, Linqiu; Shi, Aihong; Kang, Yong-Koo

doi:10.1016/j.jchromb.2009.06.021

Cited by 17 publications

(7 citation statements)

References 23 publications

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“…-based electrochemiluminescence (ECL) has become an important detection method because it is simple and economical and has low background noise, high sensitivity, good selectivity and wide dynamic linear range (14,15). Recently, the combination of ECL with CE has been used as a powerful tool for the determination of compounds such as thrombin (16), DNA (17), amino acids (18), various drugs (19)(20)(21)(22)(23)(24)(25)(26)(27)(28) and NADH (29). Most of these analytes contain tertiary amines, which provide good ECL intensities in reaction with [Ru(bpy) 3 ] 3+ without prior derivatization.…”

Section: +mentioning

confidence: 99%

Determination of metformin hydrochloride using precolumn derivatization with acetaldehyde and capillary electrophoresis coupled with electrochemiluminescence

et al. 2011

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A novel method was developed using capillary electrophoresis (CE) coupled with tris(2,2'-bipyridyl)ruthenium(II) electrogenerated chemiluminescence (ECL) for highly sensitive detection of metformin hydrochloride (MH) derivatizatized with acetaldehyde. The precolumn derivatization of MH with acetaldehyde was performed in phosphate buffer solution (0.3 mol/L, pH 7.5) at room temperature for 120 min. The effects of acetaldehyde concentration, buffer pH, electrokinetic voltage and injection time were investigated. Under optimized detection conditions, the MH ECL detection sensitivity was more than 120 times that without derivatization. The linear concentration range for MH was 0.001-15.00 μg/mL (with a correlation coefficient of 0.9992). The detection limit was 0.31 ng/mL with a signal:noise ratio of 3. The recoveries of MH in human urine were in the range 98.50-99.72%. Copyright © 2011 John Wiley & Sons, Ltd.

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confidence: 99%

Determination of metformin hydrochloride using precolumn derivatization with acetaldehyde and capillary electrophoresis coupled with electrochemiluminescence

et al. 2011

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“…15,29,30 In this paper, the urine samples were mixed with 50 μL 0.1 mol/L NaOH and 2 mL ethyl acetate, shaken for 5 min and centrifuged for 10 min at 12000 r/min. 31 The upper layer was transfered to a clean tube and dried under a stream of dry nitrogen at 80 C. Subsequently, the dry residue was dissolved in 200 μL of DDW, and the solution was filtered before analysis.…”

Section: Sample Preparationmentioning

confidence: 99%

“…The excretion amounts of PRO were obtained by multiplying the PRO concentration with the volume of urine. 31 The relationship between the excretion rate and the center of time interval was shown in Fig. 7.…”

Section: Pharmacokinetics Of Promentioning

confidence: 99%

Pharmacokinetics of Propranolol Hydrochlorid in Human Urine by Capillary Electrophoresis Coupled with Electrochemiluminescence

et al. 2011

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“…Chemiluminescence (CL), including electrochemiluminescence (ECL) analysis often offers lower background noise, inherent higher detection sensitivity, and has become a candidate for a new and sensitive CE detection scheme. Especially, CE combining with ECL (CE–ECL) based on tris(2,2′‐bipyridyl) ruthenium (II) (

{Ru (bpy)}_{3}^{2 +}

), as an efficient and sensitive analytical technique, has been extensively applied for the determination of analytes containing alkyl amines group . However, as far as we know, there are no reports on the application of CE–ECL assay to quantitative analysis of LH or IF.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous determination of lappaconitine hydrobromide and isopropiram fumarate in rabbit plasma by capillary electrophoresis with electrochemiluminescence detection

Zhou

Liu

et al. 2012

Electrophoresis

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A CE electrochemiluminescence (CE-ECL) method for simultaneous determination of lappaconitine hydrobromide (LH) and isopropiram fumarate (IF) has been first established, with a chemically modified platinum electrode by europium (III)-doped Prussian blue analogue film as a working electrode. The conditions for CE separation and ECL detection are discussed and optimized in detail. It has been proved that 20 mmol/L phosphate buffer (pH 8.5) containing 5% (v/v) ACN and 0.17 mol/L SDS could achieve the most favorable resolution, and the high sensitivity of detection was obtained by maintaining the detection potential at 1.23 V. Under optimized conditions, a baseline separation for the two analytes was achieved within 6 min, and the standard curves were linear in the range of 1.0×10(-7) ~ 5.0 × 10(-5) g/mL for LH and 4.0 × 10(-8) ~ 1.0 × 10(-5) g/mL for IF with the detection limits (3σ) of 6.6 × 10(-8) g/mL for LH and 3.7 × 10(-8) g/mL for IF, respectively. The precisions of intra- and interday measurements for LH and IF were less than 4.21 and 2.61%, respectively. The applicability of the proposed method was illustrated in the determination of LH and IF in rabbit plasma with recoveries between 95.6 and 103.0%.

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Pharmacokinetics of pefloxacin mesylate in human urine using capillary electrophoresis electrochemiluminescence detection

Cited by 17 publications

References 23 publications

Determination of metformin hydrochloride using precolumn derivatization with acetaldehyde and capillary electrophoresis coupled with electrochemiluminescence

Determination of metformin hydrochloride using precolumn derivatization with acetaldehyde and capillary electrophoresis coupled with electrochemiluminescence

Pharmacokinetics of Propranolol Hydrochlorid in Human Urine by Capillary Electrophoresis Coupled with Electrochemiluminescence

Simultaneous determination of lappaconitine hydrobromide and isopropiram fumarate in rabbit plasma by capillary electrophoresis with electrochemiluminescence detection

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