Pharmacokinetics of orally administered DL-α-lipoic acid in dogs

Abstract

Values for pharmacokinetic parameters of orally administered DL-α-lipoic acid may differ significantly when there are changes in dosage, method of administration, and fed status.

Alpha-Lipoic Acid as a Nutritive Supplement for Humans and Animals: An Overview of Its Use in Dog Food

“…The maximum serum concentrations of a-LA are within the range of values reported for other species [ 34 ] as is the time to reach peak concentrations of orally administered a-LA in plasma [ 26 , 32 , 59 , 137 ]. The peak concentration of a-LA in plasma is reduced and the time to reach the peak concentration is delayed when a-LA is an ingredient in extruded dog food compared to the peak concentration and the time to reach peak concentration if a-LA is administered orally with or without food, followed by withholding of food for 12 h [ 137 ]. Despite differences, overall, the pharmacokinetic parameters were minimally affected by the fed status of the animal when administered in capsule form.…”

“…A pharmacokinetic study of orally administered a-LA in dogs showed that pharmacokinetic parameters of a-LA were influenced by dose and the mode of administration [ 137 ]. Absorption of a-LA is reduced when it is used as an ingredient in extruded dog food compared to its absorption of a comparable dose of orally administered a-LA in the form of a capsule, given with or without food [ 137 ]. However, the concentrations of a-LA in plasma increased in proportion with the dose, regardless of its administration orally in a capsule form or as an ingredient in dog food [ 137 ].…”

“…Absorption of a-LA is reduced when it is used as an ingredient in extruded dog food compared to its absorption of a comparable dose of orally administered a-LA in the form of a capsule, given with or without food [ 137 ]. However, the concentrations of a-LA in plasma increased in proportion with the dose, regardless of its administration orally in a capsule form or as an ingredient in dog food [ 137 ]. The maximum serum concentrations of a-LA are within the range of values reported for other species [ 34 ] as is the time to reach peak concentrations of orally administered a-LA in plasma [ 26 , 32 , 59 , 137 ].…”

“…However, the concentrations of a-LA in plasma increased in proportion with the dose, regardless of its administration orally in a capsule form or as an ingredient in dog food [ 137 ]. The maximum serum concentrations of a-LA are within the range of values reported for other species [ 34 ] as is the time to reach peak concentrations of orally administered a-LA in plasma [ 26 , 32 , 59 , 137 ]. The peak concentration of a-LA in plasma is reduced and the time to reach the peak concentration is delayed when a-LA is an ingredient in extruded dog food compared to the peak concentration and the time to reach peak concentration if a-LA is administered orally with or without food, followed by withholding of food for 12 h [ 137 ].…”

“…Despite differences, overall, the pharmacokinetic parameters were minimally affected by the fed status of the animal when administered in capsule form. Delays in reaching peak concentrations in plasma in dogs fed the extruded foods may be attributable to the complex matrix used to formulate the foods and hence the slower absorption from the gastrointestinal tract [ 137 ].…”