Pharmacokinetics of oral contraceptive steroids after morning or evening administration

Kiriwat, Orawan; Fotherby, K.

doi:10.1016/0010-7824(83)90086-0

Cited by 9 publications

(3 citation statements)

References 5 publications

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“…Moreover, TAM induces a delayed increase in uterine weight when compared to EE which may be partially attributed to its weaker agonist activity but is more likely a reflection of slower absorption [26-28]. In contrast, peak serum levels of EE are detected within two hours of treatment [29]. …”

Section: Discussionmentioning

confidence: 99%

Comparative temporal and dose-dependent morphological and transcriptional uterine effects elicited by tamoxifen and ethynylestradiol in immature, ovariectomized mice

et al. 2007

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Background: Uterine temporal and dose-dependent histopathologic, morphometric and gene expression responses to the selective estrogen receptor modulator tamoxifen (TAM) were comprehensively examined to further elucidate its estrogen receptor-mediated effects. These results were systematically compared to the effects elicited by the potent estrogen receptor ligand 17α-ethynylestradiol (EE) to identify pathways similarly and uniquely modified by each compound.

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Section: Discussionmentioning

confidence: 99%

Comparative temporal and dose-dependent morphological and transcriptional uterine effects elicited by tamoxifen and ethynylestradiol in immature, ovariectomized mice

et al. 2007

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“…128 Finally, regulation of ovulatory cycles via once-daily oral contraceptives were reported to be equally effective when administered as a morning or evening dose. 143…”

Section: Other Endocrine Treatmentsmentioning

confidence: 99%

“…In regard to the time of day effects of the estrogen receptor modulator raloxifene on osteoporosis, please see the study in that section by Ando 128 . Finally, regulation of ovulatory cycles via once‐daily oral contraceptives were reported to be equally effective when administered as a morning or evening dose 143 …”

Section: Endocrine Disordersmentioning

confidence: 99%

Circadian Variation in Efficacy of Medications

Walton

Walker

Bumgarner

et al. 2020

Clin Pharma and Therapeutics

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Although much has been learned about circadian clocks and rhythms over the past few decades, translation of this foundational science underlying the temporal regulation of physiology and behavior to clinical applications has been slow. Indeed, acceptance of the modern study of circadian rhythms has been blunted because the phenomenology of cyclic changes had to counteract the 20th century dogma of homeostasis in the biological sciences and medicine. We are providing this review of clinical data to highlight the emerging awareness of circadian variation in efficacy of medications for physicians, clinicians, and pharmacists. We are suggesting that gold‐standard double‐blind clinical studies should be conducted to determine the best time of day for optimal effectiveness of medications; also, we suggest that time of day should be tracked and reported as an important biological variable in ongoing clinical studies hereafter. Furthermore, we emphasize that time of day is, and should be considered, a key biological variable in research design similar to sex. In common with biomedical research data that have been historically strongly skewed toward the male sex, most pharmaceutical data have been skewed toward morning dosing without strong evidence that this is the optimal time of efficacy.

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Pharmacokinetics of Contraceptive Steroids in Humans

Goebelsmann

1986

Contraceptive Steroids

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Pharmacokinetics of oral contraceptive steroids after morning or evening administration

Cited by 9 publications

References 5 publications

Comparative temporal and dose-dependent morphological and transcriptional uterine effects elicited by tamoxifen and ethynylestradiol in immature, ovariectomized mice

Comparative temporal and dose-dependent morphological and transcriptional uterine effects elicited by tamoxifen and ethynylestradiol in immature, ovariectomized mice

Circadian Variation in Efficacy of Medications

Pharmacokinetics of Contraceptive Steroids in Humans

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