Pharmacokinetics of mycophenolic acid in Chinese kidney transplant patients

Abstract

Abstract:To assess the influence of cyclosporin A (CsA) and tacrolimus (FK506) on mycophenolic acid (MPA) and correlation analysis of the pharmacokinetic parameters and patient characteristics, clinical outcome in Chinese kidney transplant recipients, the pharmacokinetics of 1000 mg mycophenolate mofetil (MMF) twice daily was measured by high-performance liquid chromatography (HPLC). PKS (Pharmaceutical Kinetics Software) 1.0.2 software package was used for the calculation of pharmacokinetic parameters. The mean C max , t max , and AUC (0−12) were (21.88±10.52) µg/ml, (1.20±0.95) h, and (52.546±13.215) µg·h/ml, respectively. The level of AUC (0−12) in the FK506 group was significantly higher than that in the CsA group. MPA appeared not to be affected by renal function. MPA AUC (0−12) showed statistically significant difference according to the patient's gender.

Population pharmacokinetic modelling for enterohepatic circulation of mycophenolic acid in healthy Chinese and the influence of polymorphisms in UGT1A9

“…The value of MPA CL/F is very close to that of the present study, indicating that there may be no pronounced ethnicity difference in MPA CL/ F . This result is also consistent with previous observations in Chinese [43–46] and Korean [47] renal transplant patients. In terms of MPAG CL/ F , the typical value of healthy Chinese was 46% higher than that of stable White renal transplant recipients.…”

“…CL/F of MPA and MPAG were reported to be 0.158 l h -1 kg -1 and 0.0144 l h -1 kg -1 , respectively, in patients on tacrolimus, which does not influence the EHC of MPA [40][41][42]. The value of MPA CL/F is very close to that of the present study, indicating that there may be no pronounced ethnicity difference in MPA CL/F.This result is also consistent with previous observations in Chinese [43][44][45][46] and Korean [47] renal transplant patients. In terms of MPAG CL/F, the typical value of healthy Chinese was 46% higher than that of stable White renal transplant recipients.…”

Cyclosporine A and tacrolimus combined with enteric-coated mycophenolate sodium influence the plasma mycophenolic acid concentration - a randomised controlled trial in Chinese live related donor kidney transplant recipients

“…We previously compared mean MPA AUC 0–12 h of MMF combined with CsA or Tac in 29 patients at day 7 after kidney transplantation: MPA AUC 0–12 h in the Tac group was statistically higher (60.9467 ± 11.6779 μg h/ml) than that in the CsA group (48.184 ± 10.6598 μg h/ml) (p = 0.004) . The present study obtained similar results: MPA C 0 and MPA AUC 0–12 h in the Tac group were significantly higher than in the CsA group (77.535 ± 33.615 μg h/ml vs. 59.463 ± 16.252 μg h/ml, respectively) (p = 0.002).…”

Limited Sampling Strategy for Predicting Area Under the Concentration–Time Curve for Mycophenolic Acid in Chinese Adults Receiving Mycophenolate Mofetil and Tacrolimus Early After Renal Transplantation

“…5,[8][9][10] Pharmacokinetic parameters may differ between races. Lu et al 11 studied the pharmacokinetics of MPA in 29 Chinese cases 10 days after renal transplantation, finding that, although concentration-time profiles were similar to those of white, African American, and Korean patients, there were some differences in C max , t max , and AUC 0-12h . Clinical research in Asian renal transplant recipients found that the MPA-AUC 0-12h values of patients in a stable state were significantly lower than the therapeutic window range of 30-60 mg$h$L 21 .…”