Pharmacokinetics of mycophenolate mofetil following single-dose intravenous and single- and multiple-dose oral administration and clinicopathologic effects of mycophenolate mofetil following long-term oral administration in healthy horses

Abstract

A utoimmune diseases, such as hemolytic anemia, thrombocytopenia, pemphigus, and vasculitis, in horses can be challenging with regard to treatment. [1][2][3][4][5] Corticosteroids, injectable preparations of gold salts, and, to a lesser extent, azathioprine are the only immunosuppressive treatments that have been Pharmacokinetics of mycophenolate mofetil following single-dose intravenous and single-and multipledose oral administration and clinicopathologic effects of mycophenolate mofetil following long-term oral administration in healthy horsesHeather K. Knych dvm, phd

Noncompartmental pharmacokinetics of three intravenous mycophenolate mofetil concentrations in healthy Standardbred mares

“…This result suggests that the studied MMF dose range administered once daily probably would be ineffective for treatment of autoimmune disease in horses. The geometric mean apparent T 1/2 of MPA at all doses was slightly longer than what was reported previously by Knych et al (3.99 h) 26 . In our study, the MPA T 1/2 was 5.8 h at the 10.0 mg/kg i.v.…”

“…The geometric mean apparent T 1/2 of MPA at all doses was slightly longer than what was reported previously by Knych et al (3.99 h). 26 In our study, the MPA T 1/2 was 5.8 h at the 10.0 mg/kg i.v. dose and suggests that drug plasma levels may not be sufficiently maintained with single, 24 h dosing.…”

“…Knych et al administered a single i.v. dose of MMF to horses at 2.5 mg/kg over 30 min, yet the LC–MS/MS assay ceased detection of MMF after 4 h and the detection of MMF was below the limit of quantification 26 . In our study, MMF demonstrated nonlinear PKs illustrated by decreasing C max as the dose was increased.…”

“…The previous study in horses showed a second peak approximately 3 h after MMF i.v. infusion 26 . However, the second concentration peak for MPA following i.v.…”

“…infusion. 26 However, the second concentration peak for MPA following i.v. administration was minimal in most of our six horses.…”