Pharmacokinetics of methotrexate after intravenous infusion of methotrexate-rabbit serum albumin conjugate to rabbits

Yoon, Eunju; Chang, Hong Seong; Lee, Myung G.; Lee, Hee-Joo; Park, Man K.; Kim, Chong K.

doi:10.1016/0378-5173(91)90430-v

Cited by 18 publications

(2 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In order to reduce the systemic toxicity of DTX such as cumulative fluid retention25 as well as to avoid the use of toxic excipients such as tween80, which causes severe hypersensitive reactions2, 26; we used HSA chemically conjugated to the drug as a delivery system. This nonspecific carrier, which is easily distributed in tumor tissues and possesses a long plasma half‐life in vivo , has been extensively used as a carrier in the preparation of conjugates with antineoplastic27 or antiviral28 properties. The HSA was also very attractive for the derivatization of DTX, which is almost completely insoluble in water.…”

Section: Resultsmentioning

confidence: 99%

Docetaxel–Albumin Conjugates: Preparation, In Vitro Evaluation and Biodistribution Studies

Esmaeili

Dinarvand

Ghahremani

et al. 2009

Journal of Pharmaceutical Sciences

View full text Add to dashboard Cite

Section: Resultsmentioning

confidence: 99%

Docetaxel–Albumin Conjugates: Preparation, In Vitro Evaluation and Biodistribution Studies

Esmaeili

Dinarvand

Ghahremani

et al. 2009

Journal of Pharmaceutical Sciences

View full text Add to dashboard Cite

“…The area under the plasma concentration-time curve from time zero to infinity (AUC) was calculated by the trapezoidal rule-extrapolation method (25,26).…”

Section: Pharmacokinetic Analysismentioning

confidence: 99%

Effects of water deprivation for 48 hours on the pharmacokinetics and pharmacodynamics of furosemide in rats

et al. 1995

View full text Add to dashboard Cite

The effects of water deprivation for 48 h on the pharmacokinetics and pharmacodynamics of furosemide were examined after intravenous, 8 mg/kg body weight, and oral administration, 16 mg/kg body weight, of furosemide to control and water deprived rats. After i.v. administration, the total body and nonrenal clearances decreased significantly in water-deprived rats. The urine output, urinary excretion of sodium, potassium and chloride based on grams of kidney weight, and the diuretic, natriuretic and chloruretic efficiencies decreased significantly in water-deprived rats after both intravenous and oral administration of furosemide, suggesting that the dose of furosemide for water-deprived patients may require modification.

show abstract

The pharmacokinetics of methotrexate after intravenous administration of methotrexate‐loaded proliposomes to rats

Park

Ahn

Yoon

et al. 1994

Biopharm & Drug Disp

Self Cite

View full text Add to dashboard Cite

The pharmacokinetics and tissue distribution of methotrexate (MTX) were investigated after intravenous (i.v.) injection of free MTX (treatment I), MTX-loaded proliposomes (treatment II), and empty proliposomes mixed manually with free MTX (treatment III), 8 mg kg-1, to rats using an HPLC assay. After i.v. infusion in 1 min, the plasma concentration of MTX (Cp), the area under the plasma concentration-time curve (AUC, 639 versus 913 micrograms min mL-1), the terminal half-life (t1/2, 48.8 versus 397 min), the mean residence time (MRT, 8.40 versus 325 min), and the apparent volume of distribution at steady state (Vss, 98.1 versus 2800 mL kg-1) were significantly higher; however, the total body clearance (CL, 12.5 versus 8.76 mL min-1 kg-1), renal clearance (CLR, 4.49 versus 2.78 mL min-1 kg-1), non-renal clearance (CLNR, 7.50 versus 5.99 mL min-1 kg-1), and the amount of MTX excreted in urine (Xu, 808 versus 685 micrograms, p < 0.0948) were significantly lower from treatment II than from treatment I. This could be due to the fact that some of the MTX-loaded liposomes (formed immediately after hydration of MTX-loaded proliposomes) are entrapped in tissues and the rest are present in the plasma (higher MRT and Vss from treatment II), and MTX is slowly released from MTX-loaded liposomes (higher t1/2 from treatment II). In the present HPLC assay, the concentrations of MTX represent the sum of free MTX and MTX loaded in liposomes (higher Cp and AUC, slower CL from treatment II). After i.v. infusion in 1 min, some pharmacokinetic parameters, such as t1/2, MRT, and Vss, were significantly different between treatments I and III; however, the differences seemed to be smaller than those between treatments I and II. After 30 min from i.v. infusion, the tissue to plasma (T/P) ratios of MTX in kidney and stomach from treatment II were significantly lower than those from treatment I. This suggested that the i.v. administration of MTX-loaded proliposomes might have fewer side effects in the organs than that of free MTX. The mean amount of MTX loaded in MTX-loaded proliposomes was 2.54 mg/g proliposomes and the MTX was released slowly from hydrated MTX-loaded proliposomes when incubated with phosphate-buffered saline (PBS), rat plasma, or rat liver homogenate.

show abstract

Pharmacokinetics of methotrexate after intravenous infusion of methotrexate-rabbit serum albumin conjugate to rabbits

Cited by 18 publications

References 26 publications

Docetaxel–Albumin Conjugates: Preparation, In Vitro Evaluation and Biodistribution Studies

Docetaxel–Albumin Conjugates: Preparation, In Vitro Evaluation and Biodistribution Studies

Effects of water deprivation for 48 hours on the pharmacokinetics and pharmacodynamics of furosemide in rats

The pharmacokinetics of methotrexate after intravenous administration of methotrexate‐loaded proliposomes to rats

Contact Info

Product

Resources

About