Pharmacokinetics of meptazinol after parenteral administration in the elderly

Murray, G. R.; Franklin, Richard A.; Graham, D. F.; Lewis, Richard Kurt; Bolland, M. E.

doi:10.1007/bf00541306

Cited by 6 publications

(1 citation statement)

References 7 publications

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“…The authors concluded that meptazinol is particularly suitable for the use in obstetrics [ 11 ]. Additionally, it was demonstrated that meptazinol has a rapid bioavailability, a short half-life of two hours, a wash out time of less than six hours and did not accumulate in the body irrespective of the application method [ 12 , 13 ]. The favorable side effect profile was confirmed by concurrent studies reporting the most commonly described side effects to be of gastrointestinal nature accompanied by drowsiness and dizziness [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

SPAM—sub partual analgesia with meptazinol: a prospective cohort study comparing intramuscular with intravenous administration

Germeshausen

Linzbach

Zöllkau

et al. 2023

Arch Gynecol Obstet

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Purpose Safe and effective analgesia sub partu is one of the central issues in optimizing vaginal delivery birth experiences. Meptazinol is a common opiate approved for treating labor pain in the first stage of labor. According to the manufacturer, manual meptazinol can be applied intramuscularly or intravenously. The aim of this study was to compare the two application methods in terms of efficacy in pain relief, occurrence of side effects and treatment satisfaction. Methods 132 patients with singleton term pregnancies and intended vaginal delivery, receiving meptazinol during first stage of labor were included in this prospective cohort study from 05/2020 to 01/2021. We evaluated effectiveness in pain relief and treatment satisfaction using numeric rating scales (NRS) and documented the occurrence of adverse effects. Chi-square test or Fisher exact test were used to compare categorical data and Mann–Whitney U test to compare continuous data between the two treatment groups. Statistical analysis was done by SPSS 27.0. A p value < 0.05 was considered to indicate statistical significance (two tailed). Results Meptazinol decreased labor pain significantly from a NRS of 8 (IQR 8–10) to 6 (IQR 4.75–8) in both treatment groups with no difference in effectiveness between the groups. Frequency of effective pain reduction of a decrease of 2 or more on the NRS did not differ between groups (39.4% vs 54.5%, p = 0.116), as the occurrence of adverse effects. 12% of the newborns were admitted to NICU, the median NApH was 7.195. Conclusion Meptazinol significantly reduces labor pain regardless of the method of application: intramuscular or intravenous. According to our data, no preferable route could be identified. The comparably poorer perinatal outcome in our study cohort hinders us to confirm that meptazinol is safe and can be recommended without restrictions.

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Section: Introductionmentioning

confidence: 99%

SPAM—sub partual analgesia with meptazinol: a prospective cohort study comparing intramuscular with intravenous administration

Germeshausen

Linzbach

Zöllkau

et al. 2023

Arch Gynecol Obstet

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The disposition of meptazinol after single and multiple intravenous administration to pregnant and non-pregnant women

Murray¹,

Evans

Lind

et al. 1989

Eur J Clin Pharmacol

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We have studied the disposition of the centrally-acting analgesic meptazinol in a group of age-matched non-pregnant and pregnant (36-38 weeks gestation) women. Ten non-pregnant and nine multiparous pregnant volunteers each received a single i.v. dose of meptazinol hydrochloride (equivalent to 25 mg base). A further group of 9 non-pregnant (including four of the original participants) and 10 multiparous pregnant subjects were given repeated i.v. doses of meptazinol hydrochloride (each equivalent to 10 mg base) at 30-min intervals for 2.5 h. Meptazinol plasma concentrations were determined by HPLC using fluorescence detection and the pharmacokinetic variables investigated. After single dosing there were no statistical differences in half-life, clearance, or apparent volume of distribution between the two groups, suggesting that the disposition of meptazinol was not altered by pregnancy. This was confirmed in the repeated dose study, in which no significant differences occurred in either the plasma concentrations achieved or in areas under the curves between the non-pregnant and pregnant subjects. Furthermore, the steady-state concentrations were comparable with those predicted from the single dose results. This indicates that there should be no requirement for dosage alteration of meptazinol during pregnancy.

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The systemic availability of meptazinol in man after oral and rectal doses

Murray¹,

Petitjean

Franklin³

et al. 1989

Eur J Clin Pharmacol

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We have studied the pharmacokinetics of the centrally-acting analgesic meptazinol after oral and rectal administration to 15 healthy men. Each subject took a standard 200 mg tablet orally and Witepsol H12 suppositories containing 75, 100, and 150 mg of the drug in a cross-over design. Meptazinol plasma concentrations were measured by HPLC using fluorescence detection and the pharmacokinetics determined. The tmax values for the 100 mg and 150 mg suppositories (median = 0.5 h) were statistically significantly shorter than for the tablet (median = 1.13 h), suggesting that meptazinol was more rapidly absorbed via the rectal route. Despite substantial intersubject variation in Cmax the plasma concentrations after rectal dosage were higher than after oral administration. There was a statistically significant (p less than 0.001) improvement in systemic availability for each of the suppository doses (mean approximately 15.5% compared with the oral tablet (mean approximately 4.5%).

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Pharmacokinetics of meptazinol after parenteral administration in the elderly

Cited by 6 publications

References 7 publications

SPAM—sub partual analgesia with meptazinol: a prospective cohort study comparing intramuscular with intravenous administration

SPAM—sub partual analgesia with meptazinol: a prospective cohort study comparing intramuscular with intravenous administration

The disposition of meptazinol after single and multiple intravenous administration to pregnant and non-pregnant women

The systemic availability of meptazinol in man after oral and rectal doses

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