Pharmacokinetics of meloxicam following intravenous and oral administration in green iguanas (Iguana iguana)

Abstract

Results suggested that administration of meloxicam at a dose of 0.2 mg/kg IV or PO in green iguanas would result in plasma concentrations > 0.1 μg/mL for approximately 24 hours.

Clinical Update on Diagnosis and Management of Disorders of the Digestive System of Reptiles

“…healthy green iguanas did not induce any gastric, hepatic, or renal histological tissue abnormalities. 38 However, in sick animals under stressful conditions, side effects of medications that may be used should be taken into account.…”

Pharmacokinetics of meloxicam in mature swine after intravenous and oral administration

“…To identify the optimal dose regimen for pain management, the pharmacokinetics of a drug must be determined. Pharmacokinetic (PK) parameters for meloxicam have been evaluated in several species including cattle (Coetzee et al, 2009;Mosher et al, 2012;Malreddy et al, 2013), small ruminants (Shukla et al, 2007;Ingvast-Larsson et al, 2010;Kreuder et al, 2012;Wasfi et al, 2012;Stock et al, 2013), horses (Toutain et al, 2004;Sinclair et al, 2006), exotics (Divers et al, 2010), and companion animals (Lehr et al, 2010;Lees et al, 2013). There have been two peer-reviewed articles published on meloxicam PK in swine (Fosse et al, 2008(Fosse et al, , 2010.…”

Chelonia (Tortoises, Turtles, and Terrapins)

“…To the author's knowledge a limited number of studies evaluated pharmacokinetics (PK) and pharmacodynamics (PD) of NSAIDs in chelonians. In green iguanas (Iguana iguana) the oral administration of meloxicam at 0.2 mg/kg resulted in plasma concentrations considered analgesic for mammals (Divers et al 2010). In loggerhead sea turtles (Careta careta), it was shown the clearance of meloxicam was significantly higher than reported for the iguana suggesting the need for more frequent dose intervals to maintain effective plasma concentrations (Soloperto et al 2012).…”